PDF Antibody – Rabbit Polyclonal

Protein synthesis proceeds after formylation of methionine by methionyl-tRNA formyl transferase (FMT) and transfer of the charged initiator f-met tRNA to the ribosome. In eubacteria and eukaryotic organelles the product of this gene, peptide deformylase (PDF), removes the formyl group from the initiating methionine of nascent peptides. In eubacteria, deformylation of nascent peptides is required for subsequent cleavage of initiating methionines by methionine aminopeptidase. The discovery that a natural inhibitor of PDF, actinonin, acts as an antimicrobial agent in some bacteria has spurred intensive research into the design of bacterial-specific PDF inhibitors. In human cells, only mitochondrial proteins have N-formylation of initiating methionines. Protein inhibitors of PDF or siRNAs of PDF block the growth of cancer cell lines but have no effect on normal cell growth. In humans, PDF function may therefore be restricted to rapidly growing cells.

Escobar-Alvarez, S., et al. J. Mol. Biol. 387(5):1211-1228(2009). Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008). Lee, M.D., et al. J. Clin. Invest. 114(8):1107-1116(2004). Serero, A., et al. J. Biol. Chem. 278(52):52953-52963(2003). Lee, M.D., et al. Biochem. Biophys. Res. Commun. 312(2):309-315(2003).

Small volumes of anti-PDF antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6332253 is an antibody targeting PDF. Also known as PDF, ID (PDF, PDF1A, Peptide deformylase, mitochondrial, Polypeptide deformylase) (PE). Reactive in Human. Host: Rabbit.