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PDZK1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6332585

A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and… More details

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Product Overview

Online Datasheet in PDF
Product Name
PDZK1, Polyclonal Antibody
Full Product Name
PDZK1, ID (PDZK1, CAP70, NHERF3, PDZD1, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, CFTR-associated protein of 70kD, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, PDZ domain-containing protein 1, Sodiu
Product Gene Name
anti-PDZK1 antibody
Product Synonym Names
PDZK1; CAP70; NHERF3; PDZD1; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; CFTR-associated protein of 70kD; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
44,665 Da
OMIM
603831
3D Structure
ModBase 3D Structure for Q5T2W1
Immunogen
PDZK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-224 amino acids from the Central region of human PDZK1.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-PDZK1 antibody

Antibodies; PDZ Domain
Applications Tested/Suitable for anti-PDZK1 antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-PDZK1 antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PDZK1 antibody

PDZK1 Antibody (Center) western blot analysis in NCI-H292 cell line lysates (35ug/lane).This demonstrates the PDZK1 antibody detected the PDZK1 protein (arrow).
Rabbit Anti-PDZK1 Polyclonal Antibody – Cat# MBS6332585

Immunohistochemistry (IHC) of anti-PDZK1 antibody

PDZK1 Antibody (Center) (AP14851c)immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PDZK1 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PDZK1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6332585

Product References and Citations for anti-PDZK1 antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). LaLonde, D.P., et al. Mol. Biol. Cell 21(9):1519-1529(2010). Polasek, O., et al. Croat. Med. J. 51(1):32-39(2010). Gunjaca, G., et al. Croat. Med. J. 51(1):23-31(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009).

Other Notes

Small volumes of anti-PDZK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PDZK1 purchase

MBS6332585 is an antibody targeting PDZK1. Also known as PDZK1, ID (PDZK1, CAP70, NHERF3, PDZD1, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, CFTR-associated protein of 70kD, Na(+)/H(+) exchanger regulatory factor 3, Na/Pi cotransporter C-terminal-associated protein 1, PDZ domain-containing protein 1, Sodiu. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PDZK1. It may not necessarily be applicable to this product.

NCBI GI #
21361142
NCBI GeneID
5174
NCBI Accession #
NP_002605.2
UniProt Primary Accession #
Q5T2W1
UniProt Secondary Accession #
O60450; Q5T5P6; Q9BQ41; B4DPB9; E7EU02
UniProt Related Accession #
Q5T2W1
GenBank Nucleotide #
NM_002614.4
NCBI Official Full Name
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 isoform 1
NCBI Official Synonym Full Names
PDZ domain containing 1
NCBI Official Symbol
PDZK1
NCBI Official Synonym Symbols
CAP70; CLAMP; PDZD1; NHERF3; NHERF-3
UniProt Protein Name
Na(+)/H(+) exchange regulatory cofactor NHE-RF3
UniProt Synonym Protein Names
CFTR-associated protein of 70 kDa; Na(+)/H(+) exchanger regulatory factor 3; Na/Pi cotransporter C-terminal-associated protein 1; NaPi-Cap1; PDZ domain-containing protein 1; Sodium-hydrogen exchanger regulatory factor 3
Protein Family
Na(+)/H(+) exchange regulatory cofactor
UniProt Gene Name
PDZK1
UniProt Synonym Gene Names
CAP70; NHERF3; PDZD1; NHERF-3; NaPi-Cap1
UniProt Entry Name
NHRF3_HUMAN
NCBI Protein Information
Na(+)/H(+) exchange regulatory cofactor NHE-RF3; Na(+)/H(+) exchange regulatory cofactor NHE-RF3; naPi-Cap1; PDZ-containing kidney protein 1; CFTR-associated protein of 70 kDa; sodium-hydrogen exchanger regulatory factor 3; na/Pi cotransporter C-terminal-

UniProt Comments for PDZK1

PDZK1: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function. Belongs to the NHER family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21

Cellular Component: brush border membrane; microvillus membrane; cytoplasm; apical plasma membrane; plasma membrane; lipid raft

Molecular Function: protein binding; scavenger receptor binding; transporter activity; protein complex binding; PDZ domain binding

Biological Process: cell proliferation; drug transport; transport; carnitine transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PDZK1 antibody

 Reference Product  PubMed Publications
 SCARB1 antibody  >20 publications with PDZK1 and SCARB1
 CFTR antibody  >18 publications with PDZK1 and CFTR
 PDZK1IP1 antibody  >12 publications with PDZK1 and PDZK1IP1
 SLC22A5 antibody  >7 publications with PDZK1 and SLC22A5
 SLC26A3 antibody  >5 publications with PDZK1 and SLC26A3
 AKAP10 antibody  >2 publications with PDZK1 and AKAP10
 SSTR5 antibody  >1 publications with PDZK1 and SSTR5
 ABCC2 antibody  >1 publications with PDZK1 and ABCC2

Diseases associated with anti-PDZK1 antibody

 Disease Name  Pubmed Publications
 Fibrosis Antibodies  >15 publications with PDZK1 and Fibrosis
 Cardiovascular Diseases Antibodies  >13 publications with PDZK1 and Cardiovascular Diseases
 Breast Neoplasms Antibodies  >10 publications with PDZK1 and Breast Neoplasms
 Carcinoma Antibodies  >6 publications with PDZK1 and Carcinoma
 Kidney Diseases Antibodies  >5 publications with PDZK1 and Kidney Diseases
 Inflammation Antibodies  >4 publications with PDZK1 and Inflammation
 Hypertension Antibodies  >4 publications with PDZK1 and Hypertension
 Lung Diseases Antibodies  >3 publications with PDZK1 and Lung Diseases
 Liver Diseases Antibodies  >3 publications with PDZK1 and Liver Diseases
 Myocardial Infarction Antibodies  >3 publications with PDZK1 and Myocardial Infarction

Organs/Tissues associated with anti-PDZK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >49 publications with PDZK1 and Kidney
 Liver Antibodies  >38 publications with PDZK1 and Liver
 Intestine Antibodies  >24 publications with PDZK1 and Intestine
 Embryonic Tissue Antibodies  >5 publications with PDZK1 and Embryonic Tissue
 Heart Antibodies  >4 publications with PDZK1 and Heart
 Muscle Antibodies  >3 publications with PDZK1 and Muscle
 Brain Antibodies  >3 publications with PDZK1 and Brain
 Testis Antibodies  >2 publications with PDZK1 and Testis
 Ovary Antibodies  >2 publications with PDZK1 and Ovary
 Nerve Antibodies  >2 publications with PDZK1 and Nerve
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