Rabbit Anti-PHLDA1 Polyclonal Antibody – Cat# MBS6333430

PHLDA1 Antibody (N-term) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the PHLDA1 antibody detected the PHLDA1 protein (arrow).

PHLDA1 Antibody – Rabbit Polyclonal

Name: PHLDA1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6333430
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6333430

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PHLDA1, Polyclonal Antibody

Full Product Name

PHLDA1, NT (PHLDA1, PHRIP, TDAG51, Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline-and glutamine-rich protein, Proline-and histidine-rich protein, T-cell death-associated gene 51 protein) (PE)

Product Gene Name

anti-PHLDA1 antibody

Product Synonym Names

PHLDA1; PHRIP; TDAG51; Pleckstrin homology-like domain family A member 1; Apoptosis-associated nuclear protein; Proline-and glutamine-rich protein; Proline-and histidine-rich protein; T-cell death-associated gene 51 protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

45,016 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (76419227..76425556, complement). Location: 12q15

OMIM

605335

3D Structure

ModBase 3D Structure for Q8WV24

Immunogen

PHLDA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 22-49 amino acids selected from the N-terminal region of human PHLDA1.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-PHLDA1 antibody

Antibodies; Pleckstrin Homology Proteins

Applications Tested/Suitable for anti-PHLDA1 antibody

Western Blot (WB), FLISA

Application Notes for anti-PHLDA1 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-PHLDA1 antibody

Venkatesan, K., et al. Nat. Methods 6(1):83-90(2009). Marchiori, A.C., et al. Braz. J. Med. Biol. Res. 41(7):579-582(2008). Nagai, M.A., et al. Breast Cancer Res. Treat. 106(1):49-56(2007). Xi, Z.Q., et al. Neurosci. Lett. 425(1):53-58(2007). Meier-Noorden, M., et al. Gene 338(2):197-207(2004).

Other Notes

Small volumes of anti-PHLDA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PHLDA1 purchase

MBS6333430 is an antibody targeting PHLDA1. Also known as PHLDA1, NT (PHLDA1, PHRIP, TDAG51, Pleckstrin homology-like domain family A member 1, Apoptosis-associated nuclear protein, Proline-and glutamine-rich protein, Proline-and histidine-rich protein, T-cell death-associated gene 51 protein) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PHLDA1. It may not necessarily be applicable to this product.

NCBI GI #

83977459

NCBI GeneID

22822

NCBI Accession #

NP_031376.3

UniProt Primary Accession #

Q8WV24

UniProt Secondary Accession #

Q15184; Q2TAN2; Q9NZ17; A1A4G9

UniProt Related Accession #

Q8WV24

GenBank Nucleotide #

NM_007350.3

NCBI Official Full Name

pleckstrin homology-like domain family A member 1

NCBI Official Synonym Full Names

pleckstrin homology-like domain, family A, member 1

NCBI Official Symbol

PHLDA1

NCBI Official Synonym Symbols

PHRIP; TDAG51; DT1P1B11

UniProt Protein Name

Pleckstrin homology-like domain family A member 1

UniProt Synonym Protein Names

Apoptosis-associated nuclear protein; Proline- and glutamine-rich protein; PQ-rich protein; PQR protein; Proline- and histidine-rich protein; T-cell death-associated gene 51 protein

Protein Family

Pleckstrin homology-like domain family

UniProt Gene Name

PHLDA1

UniProt Synonym Gene Names

PHRIP; TDAG51; PQ-rich protein; PQR protein

UniProt Entry Name

PHLA1_HUMAN

NCBI Protein Information

pleckstrin homology-like domain family A member 1; PQR protein; PQ-rich protein; proline-histidine rich protein; proline- and glutamine-rich protein; proline- and histidine-rich protein; apoptosis-associated nuclear protein; T-cell death-associated gene 5

UniProt Comments for PHLDA1

PHLDA1: Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation.

Protein type: Nucleolus; Apoptosis

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nucleoplasm; cytoplasmic vesicle membrane; nucleolus; plasma membrane

Molecular Function: protein binding

Biological Process: apoptosis; positive regulation of apoptosis; forebrain neuron differentiation; FasL biosynthetic process

Research Articles on PHLDA1

1. the release of Ca(2+) from endoplasmic reticulum stores mediates epithelial-to-mesenchymal transition in human proximal tubular epithelium via the induction of TDAG51

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PHLDA1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>23 publications with PHLDA1 and Neoplasms
Carcinoma Antibodies	>14 publications with PHLDA1 and Carcinoma
Breast Neoplasms Antibodies	>5 publications with PHLDA1 and Breast Neoplasms
Inflammation Antibodies	>4 publications with PHLDA1 and Inflammation
Cardiovascular Diseases Antibodies	>3 publications with PHLDA1 and Cardiovascular Diseases
Nervous System Diseases Antibodies	>3 publications with PHLDA1 and Nervous System Diseases
Fibrosis Antibodies	>2 publications with PHLDA1 and Fibrosis
Cell Transformation, Neoplastic Antibodies	>2 publications with PHLDA1 and Cell Transformation, Neoplastic
Melanoma Antibodies	>2 publications with PHLDA1 and Melanoma
Kidney Diseases Antibodies	>2 publications with PHLDA1 and Kidney Diseases

Organs/Tissues associated with anti-PHLDA1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>11 publications with PHLDA1 and Blood
Skin Antibodies	>10 publications with PHLDA1 and Skin
Embryonic Tissue Antibodies	>5 publications with PHLDA1 and Embryonic Tissue
Kidney Antibodies	>3 publications with PHLDA1 and Kidney
Bone Antibodies	>3 publications with PHLDA1 and Bone
Mammary Gland Antibodies	>3 publications with PHLDA1 and Mammary Gland
Brain Antibodies	>3 publications with PHLDA1 and Brain
Intestine Antibodies	>2 publications with PHLDA1 and Intestine
Liver Antibodies	>2 publications with PHLDA1 and Liver
Heart Antibodies	>2 publications with PHLDA1 and Heart