Mouse Anti-CCDC6 Monoclonal Antibody – Cat# MBS633490

CCDC6 Antibody – Mouse Monoclonal

Name: CCDC6 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS633490
Price: 880 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS633490

CCDC6 (Coiled-coil domain-containing protein 6) was identified due to its frequent rearrangement with RET in papillary thyroid tumors (RET/PTC1). CCDC6 may function in the (ataxia telangectasia mutated) ATM-mediated cellular response to DNA damage. More details

$880 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCDC6, Monoclonal Antibody

Full Product Name

CCDC6 (Coiled-coil Domain Containing 6, Coiled-coil Domain-containing Protein 6, D10S170, FLJ32286, H4, Papillary Thyroid Carcinoma-encoded Protein, PTC, Protein H4, TPC, TST1)

Product Gene Name

anti-CCDC6 antibody

Product Synonym Names

Anti -CCDC6 (Coiled-coil Domain Containing 6, Coiled-coil Domain-containing Protein 6, D10S170, FLJ32286, H4, Papillary Thyroid Carcinoma-encoded Protein, PTC, Protein H4, TPC, TST1)

Clonality

Monoclonal

Isotype

IgG1, k

Clone Number

5D11

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Purified
Purified.

Specificity

Recognizes human CCDC6.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

53,291 Da

Chromosome Location

Chromosome: 10; NC_000010.10 (61548521..61666818, complement). Location: 10q21

OMIM

188550

3D Structure

ModBase 3D Structure for Q16204

Immunogen

CCDC6 (NP_005427, 375-475aa) partial recombinant protein with GST tag. MW of the GST tag alone is 26kD.

Product Categories/Family for anti-CCDC6 antibody

Antibodies; Abs to DNA Replication; Repair

Applications Tested/Suitable for anti-CCDC6 antibody

ELISA (EL/EIA), Western Blot (WB)

Application Notes for anti-CCDC6 antibody

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of anti-CCDC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCDC6 purchase

MBS633490 is an antibody targeting CCDC6. Also known as CCDC6 (Coiled-coil Domain Containing 6, Coiled-coil Domain-containing Protein 6, D10S170, FLJ32286, H4, Papillary Thyroid Carcinoma-encoded Protein, PTC, Protein H4, TPC, TST1). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CCDC6. It may not necessarily be applicable to this product.

NCBI GI #

46852390

NCBI GeneID

8030

NCBI Accession #

NP_005427.2

UniProt Primary Accession #

Q16204

UniProt Secondary Accession #

Q15250; Q6GSG7

UniProt Related Accession #

Q05CP8; Q16204

GenBank Nucleotide #

NM_005436.4

NCBI Official Full Name

coiled-coil domain-containing protein 6

NCBI Official Synonym Full Names

coiled-coil domain containing 6

NCBI Official Symbol

CCDC6

NCBI Official Synonym Symbols

H4; PTC; TPC; TST1; D10S170; FLJ32286

UniProt Protein Name

Coiled-coil domain-containing protein 6

UniProt Synonym Protein Names

Papillary thyroid carcinoma-encoded protein; Protein H4

Protein Family

Coiled-coil domain-containing protein

UniProt Gene Name

CCDC6

UniProt Synonym Gene Names

D10S170; TST1

UniProt Entry Name

CCDC6_HUMAN

NCBI Protein Information

coiled-coil domain-containing protein 6; OTTHUMP00000019644; papillary thyroid carcinoma-encoded protein

NCBI Summary for CCDC6

This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.

UniProt Comments for CCDC6

CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene.

Protein type: Apoptosis; Cytoskeletal; Oncoprotein

Chromosomal Location of Human Ortholog: 10q21

Cellular Component: cytoskeleton; cytoplasm

Molecular Function: protein binding; structural constituent of cytoskeleton; SH3 domain binding

Disease: Thyroid Carcinoma, Papillary

Research Articles on CCDC6

1. repression of CREB1 activity by CCDC6 has a critical function in the development of human thyroid papillary carcinomas carrying RET/PTC1 activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CCDC6 antibody

Products by Pathway	Pathway Diagram
Pathways In Cancer antibodies	Pathways In Cancer Diagram
Thyroid Cancer Pathway antibodies	Thyroid Cancer Pathway Diagram
Thyroid Cancer Pathway antibodies	Thyroid Cancer Pathway Diagram

Diseases associated with anti-CCDC6 antibody

Disease Name	Pubmed Publications
Thyroid Diseases Antibodies	>12 publications with CCDC6 and Thyroid Diseases
Carcinoma Antibodies	>8 publications with CCDC6 and Carcinoma
Chromosome Breakage Antibodies	>3 publications with CCDC6 and Chromosome Breakage
Cell Transformation, Neoplastic Antibodies	>3 publications with CCDC6 and Cell Transformation, Neoplastic
Breast Neoplasms Antibodies	>2 publications with CCDC6 and Breast Neoplasms
Skin Neoplasms Antibodies	>1 publications with CCDC6 and Skin Neoplasms
Medulloblastoma Antibodies	>1 publications with CCDC6 and Medulloblastoma
Lymphoma Antibodies	>1 publications with CCDC6 and Lymphoma

Organs/Tissues associated with anti-CCDC6 antibody

Organ/Tissue Name	Pubmed Publications
Thyroid Antibodies	>15 publications with CCDC6 and Thyroid
Blood Antibodies	>3 publications with CCDC6 and Blood
Mammary Gland Antibodies	>2 publications with CCDC6 and Mammary Gland
Bone Antibodies	>1 publications with CCDC6 and Bone
Skin Antibodies	>1 publications with CCDC6 and Skin
Placenta Antibodies	>1 publications with CCDC6 and Placenta
Embryonic Tissue Antibodies	>1 publications with CCDC6 and Embryonic Tissue
Uterus Antibodies	>1 publications with CCDC6 and Uterus
Brain Antibodies	>1 publications with CCDC6 and Brain