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SIRP, Gamma (SIRPG) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS633573

MBS633573 is an antibody targeting SIRPG. Also known as SIRP, gamma (Signal Regulatory Protein gamma, SIRPG, CD172 gamma, CD172g, CD172g Antigen, Signal Regulatory Protein beta 2, SIRP beta 2, SIRPbeta2, SIRP-beta-2, SIRP B2, SIRPB2, SIRP-B2). Reactive in… More details

$890 / 0.2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SIRP, gamma (SIRPG), Monoclonal Antibody
Full Product Name
SIRP, gamma (Signal Regulatory Protein gamma, SIRPG, CD172 gamma, CD172g, CD172g Antigen, Signal Regulatory Protein beta 2, SIRP beta 2, SIRPbeta2, SIRP-beta-2, SIRP B2, SIRPB2, SIRP-B2)
Product Gene Name
Product Synonym Names
Anti -SIRP, gamma (Signal Regulatory Protein gamma, SIRPG, CD172 gamma, CD172g, CD172g Antigen, Signal Regulatory Protein beta 2, SIRP beta 2, SIRPbeta2, SIRP-beta-2, SIRP B2, SIRPB2, SIRP-B2)
Clonality
Monoclonal
Isotype
IgG1
Clone Number
10B880
Host
Mouse
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.4, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human SIRP gamma (CD172g).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
42,498 Da
Chromosome Location
Chromosome: 20; NC_000020.10 (1609798..1638425, complement). Location: 20p13
OMIM
605466
3D Structure
ModBase 3D Structure for Q9P1W8
Immunogen
Purified recombinant SIRPgamma.CD4.
Hybridoma
NS-1 myeloma cells with spleen cells from Balb/c mice.

Product Categories/Family for anti-SIRPG antibody

Applications Tested/Suitable for anti-SIRPG antibody
Immunoprecipitation (IP), Flow Cytometry (FC/FACS)
Application Notes for anti-SIRPG antibody
Suitable for use in Flow Cytometry and Immunoprecipitation.
Dilution: Flow Cytometry: 1:50-1:200; 10ul labels 10e6 cells in 100ul

Other Notes

Small volumes of anti-SIRPG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SIRPG. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
signal-regulatory protein gamma isoform 2
NCBI Official Synonym Full Names
signal-regulatory protein gamma
NCBI Official Symbol
SIRPG
NCBI Official Synonym Symbols
CD172g; SIRPB2; SIRP-B2; FLJ42230; bA77C3.1; SIRPgamma
UniProt Protein Name
Signal-regulatory protein gamma
UniProt Synonym Protein Names
CD172 antigen-like family member B; Signal-regulatory protein beta-2
UniProt Gene Name
SIRPG
UniProt Synonym Gene Names
SIRPB2
UniProt Entry Name
SIRPG_HUMAN
NCBI Protein Information
signal-regulatory protein gamma; SIRP-gamma; SIRP beta 2; SIRP-beta-2; CD172g antigen; OTTHUMP00000029998; OTTHUMP00000029999; OTTHUMP00000030000; OTTHUMP00000185041; signal-regulatory protein beta 2; signal-regulatory protein beta-2; CD172 antigen-like family member B

NCBI Summary for SIRPG

The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]
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UniProt Comments for SIRPG

SIRPG: Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p13

Cellular Component: membrane; integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: negative regulation of cell proliferation; cell-cell signaling; positive regulation of cell proliferation; positive regulation of cell-cell adhesion; positive regulation of T cell activation; blood coagulation; cell adhesion; leukocyte migration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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