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PP1R14C Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6336078

The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism,… More details

$1060 / 0.1 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
PP1R14C, Polyclonal Antibody
Full Product Name
PP1R14C, CT (PPP1R14C, KEPI, Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81) (MaxLight 550)
Product Gene Name
anti-PP1R14C antibody
Product Synonym Gene Name
PPP1R14C
Product Synonym Names
PPP1R14C; KEPI; Protein phosphatase 1 regulatory subunit 14C; Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human PP1R14C. Species crossreactivity: mouse.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
17,843 Da
Chromosome Location
Chromosome: 6; NC_000006.11 (150464188..150571528). Location: 6q24.3-q25.3
OMIM
613242
3D Structure
ModBase 3D Structure for Q8TAE6
Immunogen
PP1R14C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-163 amino acids from the C-terminal region of human PP1R14C.
Conjugate
MaxLight550
Note
Preservative Free

Product Categories/Family for anti-PP1R14C antibody

Antibodies; Protein Kinases
Applications Tested/Suitable for anti-PP1R14C antibody
Immunohistochemistry (IHC), Western Blot (WB), FLISA
Application Notes for anti-PP1R14C antibody
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-PP1R14C antibody

1. Daskalow, K., et al. Anticancer Res. 30(5):1573-1578(2010). 2. Scholz, S.W., et al. Ann. Neurol. 65(5):610-614(2009). 3. Burgner, D., et al. PLoS Genet. 5 (1), E1000319 (2009). 4. Mungall, A.J., et al. Nature 425(6960):805-811(2003). 5. Liu, Q.R., et al. J. Biol. Chem. 277(15):13312-13320(2002).

Other Notes

Small volumes of anti-PP1R14C antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PP1R14C purchase

MBS6336078 is an antibody targeting PP1R14C. Also known as PP1R14C, CT (PPP1R14C, KEPI, Protein phosphatase 1 regulatory subunit 14C, Kinase-enhanced PP1 inhibitor, PKC-potentiated PP1 inhibitory protein, Serologically defined breast cancer antigen NY-BR-81) (MaxLight 550). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PP1R14C. It may not necessarily be applicable to this product.

NCBI GI #
19311006
NCBI GeneID
81706
NCBI Accession #
NP_112211.1
UniProt Primary Accession #
Q8TAE6
UniProt Secondary Accession #
Q5VY83; Q96BB1; Q9H277
UniProt Related Accession #
Q8TAE6
GenBank Nucleotide #
NM_030949.2
NCBI Official Full Name
protein phosphatase 1 regulatory subunit 14C
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory (inhibitor) subunit 14C
NCBI Official Symbol
PPP1R14C
NCBI Official Synonym Symbols
KEPI; NY-BR-81; CPI17-like
UniProt Protein Name
Protein phosphatase 1 regulatory subunit 14C
UniProt Synonym Protein Names
Kinase-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; Serologically defined breast cancer antigen NY-BR-81
UniProt Gene Name
PPP1R14C
UniProt Synonym Gene Names
KEPI
UniProt Entry Name
PP14C_HUMAN
NCBI Protein Information
protein phosphatase 1 regulatory subunit 14C; kinase-enhanced PP1 inhibitor; kinase C-enhanced PP1 inhibitor; PKC-potentiated PP1 inhibitory protein; serologically defined breast cancer antigen NY-BR-81

NCBI Summary for PP1R14C

The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]
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UniProt Comments for PP1R14C

KEPI: Inhibitor of PPP1CA. Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. Belongs to the PP1 inhibitor family.

Protein type: Inhibitor; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 6q24.3-q25.3

Cellular Component: membrane; cytoplasm

Molecular Function: type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: regulation of phosphorylation; negative regulation of catalytic activity
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Research Articles on PP1R14C

1. analysis of antibodies generated against the protein phosphatase 1 inhibitor KEPI and characterization of the epitope

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-PP1R14C antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >3 publications with PP1R14C and Neoplasms
 Head and Neck Neoplasms Antibodies  >1 publications with PP1R14C and Head and Neck Neoplasms
 Inflammation Antibodies  >1 publications with PP1R14C and Inflammation
 Breast Neoplasms Antibodies  >1 publications with PP1R14C and Breast Neoplasms
 Heart Failure Antibodies  >1 publications with PP1R14C and Heart Failure
 Heart Diseases Antibodies  >1 publications with PP1R14C and Heart Diseases

Organs/Tissues associated with anti-PP1R14C antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with PP1R14C and Brain
 Muscle Antibodies  >3 publications with PP1R14C and Muscle
 Heart Antibodies  >2 publications with PP1R14C and Heart
 Lymph Node Antibodies  >1 publications with PP1R14C and Lymph Node
 Embryonic Tissue Antibodies  >1 publications with PP1R14C and Embryonic Tissue
 Mouth Antibodies  >1 publications with PP1R14C and Mouth
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