Mouse Anti-H2-K1 Monoclonal Antibody – Cat# MBS633611

MHC Class 1, H-2kb (H2-K1) Antibody – Mouse Monoclonal

Name: H2-K1 Antibody; Monoclonal; Mouse; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS633611
Price: 690 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS633611

The major histocompatibility complex (MHC) is a cluster of genes that are important in the immune response to infections. In mice, this complex is referred to as the histocompatibility 2 (H-2) region. There are 3 major MHC class I proteins encoded by the H-2… More details

$690 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MHC Class 1, H-2Kb (H2-K1), Monoclonal Antibody

Full Product Name

MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092) (FITC)

Product Gene Name

anti-H2-K1 antibody

Product Synonym Names

Anti -MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092) (FITC)

Clonality

Monoclonal

Isotype

IgG2a

Clone Number

AF6-88.5

Host

Mouse

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide. Labeled with fluorescein isothiocyanate (FITC).

Purity/Purification

Affinity Purified
Purified by affinity chromatography

Specificity

Recognizes the H-2Kb determinant present on all nucleated cells of mice expressing this MHC class I haplotype. Does not cross react with other haplotypes.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. FITC conjugates are sensitive to light.

Molecular Weight

41,302 Da

Chromosome Location

Chromosome: 17; NC_000083.5 (34132957..34137278, complement). Location: 17 B1; 17 18.44 cM

3D Structure

ModBase 3D Structure for P01901

Immunogen

C57BL mouse splenocytes

Product Categories/Family for anti-H2-K1 antibody

Antibodies; Abs to MHC

Applications Tested/Suitable for anti-H2-K1 antibody

Flow Cytometry (FC/FACS)

Application Notes for anti-H2-K1 antibody

Suitable for use in Flow Cytometry.
Dilution: Flow Cytometry: 1:10-1:20; 10ul labels 10e6 cells in 100ul

Other Notes

Small volumes of anti-H2-K1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for H2-K1 purchase

MBS633611 is an antibody targeting H2-K1. Also known as MHC Class 1, H-2Kb (MHC Class I H-2Kb, H-2 Class I Histocompatibility Antigen K-B alpha Chain, H-2K(B), H2-K1, H-2K, H2-K, H-2K(d), MGC7052, MGC184092) (FITC). Reactive in Mouse. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for H2-K1. It may not necessarily be applicable to this product.

NCBI GI #

5531260

NCBI GeneID

14972

UniProt Primary Accession #

P01901

UniProt Related Accession #

O19449; O19468; O35641; P01901; P01902; P03991; P04223; P14428; Q1XIR8; Q31141

NCBI Official Full Name

MHC class I antigen H-2K

NCBI Official Synonym Full Names

histocompatibility 2, K1, K region

NCBI Official Symbol

H2-K1

NCBI Official Synonym Symbols

K-f; H-2K; H2-K; H-2K(d); MGC7052; MGC184092

UniProt Protein Name

H-2 class I histocompatibility antigen, K-B alpha chain

Protein Family

H-2 class I histocompatibility antigen

UniProt Gene Name

H2-K1

UniProt Synonym Gene Names

H2-K

UniProt Entry Name

HA1B_MOUSE

NCBI Protein Information

H-2 class I histocompatibility antigen, K-W28 alpha chain; H-2K(B); H-2K(K); H-2K(Q); MHC class I antigen; MHC class I heavy chain H2-K; MHC H2-K transplantation antigen; class I major histocompatibility antigen H-2Kd; MHC class I H2-K-b-alpha-2 cell surface glycoprotein; H-2 class I histocompatibility antigen, K-B alpha chain; H-2 class I histocompatibility antigen, K-D alpha chain; H-2 class I histocompatibility antigen, K-K alpha chain; H-2 class I histocompatibility antigen, K-Q alpha chain

UniProt Comments for H2-K1

HLAC iso22: Involved in the presentation of foreign antigens to the immune system. Belongs to the MHC class I family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: Golgi apparatus; cell surface; membrane; endoplasmic reticulum; integral to membrane; MHC class I protein complex; Golgi medial cisterna; external side of plasma membrane

Molecular Function: protein binding; peptide antigen binding; beta-2-microglobulin binding; protein heterodimerization activity; T cell receptor binding; peptide binding; TAP binding; receptor binding

Biological Process: antigen processing and presentation; antigen processing and presentation of peptide antigen via MHC class I; immune system process; positive regulation of T cell mediated cytotoxicity; defense response to bacterium; antigen processing and presentation of exogenous peptide antigen via MHC class I; immune response; inner ear development; antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

Research Articles on H2-K1

1. Adult mice exposed to a noninherited maternal antigen accepts permanently H2-Kb-positive heart allografts despite the presence of normal levels of anti-K(b) T cell receptor transgenic T cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-H2-K1 antibody

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Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram

Diseases associated with anti-H2-K1 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>1 publications with H2-K1 and Inflammation

Organs/Tissues associated with anti-H2-K1 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with H2-K1 and Lung
Spleen Antibodies	>1 publications with H2-K1 and Spleen
Blood Antibodies	>1 publications with H2-K1 and Blood