Rabbit Anti-PPARA Polyclonal Antibody – Cat# MBS6336121

PPARA Antibody – Rabbit Polyclonal

Name: PPARA Antibody; Polyclonal; Rabbit; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6336121
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6336121

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PPARA, Polyclonal Antibody

Full Product Name

PPARA, ID (PPARA, NR1C1, PPAR, Peroxisome proliferator-activated receptor alpha, Nuclear receptor subfamily 1 group C member 1) (MaxLight 490)

Product Gene Name

anti-PPARA antibody

Product Synonym Names

PPARA; NR1C1; PPAR; Peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight490.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight490 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

18,942 Da

OMIM

170998

3D Structure

ModBase 3D Structure for Q07869

Immunogen

PPARA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 152-181 amino acids from the Central region of human PPARA.

Conjugate

MaxLight490

Note

Preservative Free

Product Categories/Family for anti-PPARA antibody

Antibodies; Obesity Proteins

Applications Tested/Suitable for anti-PPARA antibody

Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)

Application Notes for anti-PPARA antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-PPARA antibody

Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010). Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010). Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010): Eynon, N., et al. Mitochondrion (2010). In press: Aldhoon, B., et al. Folia Biol. (Praha) 56(3):116-123(2010).

Other Notes

Small volumes of anti-PPARA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PPARA purchase

MBS6336121 is an antibody targeting PPARA. Also known as PPARA, ID (PPARA, NR1C1, PPAR, Peroxisome proliferator-activated receptor alpha, Nuclear receptor subfamily 1 group C member 1) (MaxLight 490). Reactive in Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PPARA. It may not necessarily be applicable to this product.

NCBI GI #

7549811

NCBI GeneID

5465

NCBI Accession #

NP_005027.2

NCBI Related Accession #

NP_001001928.1

UniProt Primary Accession #

Q07869

UniProt Secondary Accession #

Q16241; Q6I9S0; Q92486; Q92689; Q9Y3N1; B0G0X3

UniProt Related Accession #

Q07869

GenBank Nucleotide #

NM_005036.4

NCBI Official Full Name

peroxisome proliferator-activated receptor alpha

NCBI Official Synonym Full Names

peroxisome proliferator-activated receptor alpha

NCBI Official Symbol

PPARA

NCBI Official Synonym Symbols

PPAR; NR1C1; hPPAR; PPARalpha

UniProt Protein Name

Peroxisome proliferator-activated receptor alpha

UniProt Synonym Protein Names

Nuclear receptor subfamily 1 group C member 1

Protein Family

Peroxisome proliferator-activated receptor

UniProt Gene Name

PPARA

UniProt Synonym Gene Names

NR1C1; PPAR; PPAR-alpha

UniProt Entry Name

PPARA_HUMAN

NCBI Protein Information

peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3

UniProt Comments for PPARA

PPAR-alpha: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily.

Protein type: Nuclear receptor; DNA-binding

Chromosomal Location of Human Ortholog: 22q13.31

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; drug binding; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; sequence-specific DNA binding; protein complex binding; steroid hormone receptor activity; transcription factor activity; lipid binding

Biological Process: circadian rhythm; epidermis development; wound healing; heart development; positive regulation of transcription, DNA-dependent; behavioral response to nicotine; negative regulation of transcription from RNA polymerase II promoter; cellular lipid metabolic process; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; circadian regulation of gene expression; negative regulation of blood pressure; negative regulation of protein binding; negative regulation of glycolysis; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; lipoprotein metabolic process; regulation of circadian rhythm; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid oxidation; response to hypoxia; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; lipid metabolic process; fatty acid transport

Research Articles on PPARA

1. Adiponectin limits fetal growth mediated by activation of placental PPARalpha and ceramide synthesis, which inhibits placental insulin signaling and amino acid transport, resulting in reduced fetal nutrient availability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PPARA antibody

Reference Product	PubMed Publications
ABCA1 antibody	>11 publications with PPARA and ABCA1
RXRA antibody	>11 publications with PPARA and RXRA
APOA5 antibody	>3 publications with PPARA and APOA5
HIF1A antibody	>2 publications with PPARA and HIF1A
PLIN2 antibody	>2 publications with PPARA and PLIN2
CLOCK antibody	>1 publications with PPARA and CLOCK
EP300 antibody	>1 publications with PPARA and EP300
NCOA1 antibody	>1 publications with PPARA and NCOA1

Pathways associated with anti-PPARA antibody

Products by Pathway	Pathway Diagram
Activation Of Gene Expression By SREBF (SREBP) Pathway antibodies	Activation Of Gene Expression By SREBF (SREBP) Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipogenesis Pathway antibodies	Adipogenesis Pathway Diagram
BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway antibodies	BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway Diagram
Circadian Clock Pathway antibodies	Circadian Clock Pathway Diagram
Developmental Biology Pathway antibodies	Developmental Biology Pathway Diagram
Energy Metabolism Pathway antibodies	Energy Metabolism Pathway Diagram
Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies	Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram

Diseases associated with anti-PPARA antibody

Disease Name	Pubmed Publications
Fatty Liver Antibodies	>55 publications with PPARA and Fatty Liver
Cardiovascular Diseases Antibodies	>42 publications with PPARA and Cardiovascular Diseases
Liver Diseases Antibodies	>39 publications with PPARA and Liver Diseases
Obesity Antibodies	>35 publications with PPARA and Obesity
Inflammation Antibodies	>33 publications with PPARA and Inflammation
Heart Diseases Antibodies	>24 publications with PPARA and Heart Diseases
Insulin Resistance Antibodies	>24 publications with PPARA and Insulin Resistance
Atherosclerosis Antibodies	>19 publications with PPARA and Atherosclerosis
Dyslipidemias Antibodies	>17 publications with PPARA and Dyslipidemias
Diabetes Mellitus, Type 2 Antibodies	>14 publications with PPARA and Diabetes Mellitus, Type 2

Organs/Tissues associated with anti-PPARA antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>82 publications with PPARA and Blood
Muscle Antibodies	>33 publications with PPARA and Muscle
Heart Antibodies	>26 publications with PPARA and Heart
Connective Tissue Antibodies	>13 publications with PPARA and Connective Tissue
Intestine Antibodies	>10 publications with PPARA and Intestine
Vascular Antibodies	>9 publications with PPARA and Vascular
Brain Antibodies	>9 publications with PPARA and Brain
Placenta Antibodies	>8 publications with PPARA and Placenta
Bone Antibodies	>6 publications with PPARA and Bone
Embryonic Tissue Antibodies	>5 publications with PPARA and Embryonic Tissue