PPM1D Antibody – Rabbit Polyclonal

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.

1. Zhang, X., et al. Cancer Res. 70(18):7176-7186(2010). 2. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 3. Moon, S.H., et al. J. Biol. Chem. 285(17):12935-12947(2010). 4. Macurek, L., et al. Oncogene 29(15):2281-2291(2010). 5. Yang, D.H., et al. Zhonghua Yi Xue Za Zhi 90(8):519-522(2010).

Small volumes of anti-PPM1D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS6336385 is an antibody targeting PPM1D. Also known as PPM1D, ID (PPM1D, WIP1, Protein phosphatase 1D, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1) (MaxLight 490). Reactive in Human. Host: Rabbit.