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PRCP Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6337020

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is… More details

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Product Overview

Online Datasheet in PDF
Product Name
PRCP, Polyclonal Antibody
Full Product Name
PRCP, NT (PRCP, PCP, Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase) (FITC)
Product Gene Name
anti-PRCP antibody
Product Synonym Names
PRCP; PCP; Lysosomal Pro-X carboxypeptidase; Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
55,800 Da
OMIM
176785
3D Structure
ModBase 3D Structure for P42785
Immunogen
PRCP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 113-143 amino acids from the N-terminal region of human PRCP.
Conjugate
FITC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-PRCP antibody

Antibodies; Enzymes; Carboxypeptidase
Applications Tested/Suitable for anti-PRCP antibody
Immunohistochemistry (IHC), FLISA, Western Blot (WB)
Application Notes for anti-PRCP antibody
IHC: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PRCP antibody

PRCP Antibody (N-term) western blot analysis in MDA-MB231,Hela cell line lysates (35ug/lane).This demonstrates the PRCP antibody detected the PRCP protein (arrow).
Rabbit Anti-PRCP Polyclonal Antibody – Cat# MBS6337020

Immunohistochemistry (IHC) of anti-PRCP antibody

PRCP Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PRCP Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PRCP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6337020

Product References and Citations for anti-PRCP antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Zhao, X., et al. Proteomics 10(15):2882-2886(2010). Abeywickrema, P.D., et al. Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (PT 6), 702-705 (2010): Soisson, S.M., et al. BMC Struct. Biol. 10, 16 (2010): Zhang, Y., et al. Chin. Med. J. 122(20):2461-2465(2009).

Other Notes

Small volumes of anti-PRCP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PRCP purchase

MBS6337020 is an antibody targeting PRCP. Also known as PRCP, NT (PRCP, PCP, Lysosomal Pro-X carboxypeptidase, Angiotensinase C, Lysosomal carboxypeptidase C, Proline carboxypeptidase, Prolylcarboxypeptidase) (FITC). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PRCP. It may not necessarily be applicable to this product.

NCBI GI #
4826940
NCBI GeneID
5547
NCBI Accession #
NP_005031.1
UniProt Primary Accession #
P42785
UniProt Secondary Accession #
A8MU24; B2R7B7; B3KRK5; B5BU34
UniProt Related Accession #
P42785
GenBank Nucleotide #
NM_005040.2
NCBI Official Full Name
lysosomal Pro-X carboxypeptidase isoform 1 preproprotein
NCBI Official Synonym Full Names
prolylcarboxypeptidase (angiotensinase C)
NCBI Official Symbol
PRCP
NCBI Official Synonym Symbols
PCP; HUMPCP
UniProt Protein Name
Lysosomal Pro-X carboxypeptidase
UniProt Synonym Protein Names
Angiotensinase C; Lysosomal carboxypeptidase C; Proline carboxypeptidase; Prolylcarboxypeptidase; PRCP
Protein Family
Lysosomal Pro-X carboxypeptidase
UniProt Gene Name
PRCP
UniProt Synonym Gene Names
PCP; PRCP
UniProt Entry Name
PCP_HUMAN
NCBI Protein Information
lysosomal Pro-X carboxypeptidase; angiotensinase C; proline carboxypeptidase; lysosomal carboxypeptidase C; prolylcarboxypeptidase isoform 1 preproprotein

NCBI Summary for PRCP

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
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UniProt Comments for PRCP

PRCP: Cleaves C-terminal amino acids linked to proline in peptides such as angiotensin II, III and des-Arg9-bradykinin. This cleavage occurs at acidic pH, but enzymatic activity is retained with some substrates at neutral pH. Belongs to the peptidase S28 family.

Protein type: EC 3.4.16.2; Protease

Chromosomal Location of Human Ortholog: 11q14

Cellular Component: lysosome; plasma membrane

Molecular Function: serine carboxypeptidase activity; protein binding

Biological Process: plasma kallikrein-kinin cascade; negative regulation of systemic arterial blood pressure; regulation of blood vessel endothelial cell migration; glucose homeostasis; proteolysis; blood coagulation; angiogenesis involved in wound healing; blood coagulation, intrinsic pathway
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Research Articles on PRCP

1. The present results indicated PRCP rs7104980 can be considered as a marker for EH and Hap3 GAGCACTAACA (PRCP) and Hap16 TTTA (CMA1) might be associated with essential hypertension in Chinese Han population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRCP antibody

 Products by Pathway  Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway antibodies  Intrinsic Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram
 Protein Digestion And Absorption Pathway antibodies  Protein Digestion And Absorption Pathway Diagram

Diseases associated with anti-PRCP antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >9 publications with PRCP and Hypertension
 Vascular Diseases Antibodies  >8 publications with PRCP and Vascular Diseases
 Thrombosis Antibodies  >3 publications with PRCP and Thrombosis
 Cerebrovascular Disorders Antibodies  >2 publications with PRCP and Cerebrovascular Disorders
 Brain Diseases Antibodies  >2 publications with PRCP and Brain Diseases
 Infection Antibodies  >2 publications with PRCP and Infection
 Kidney Diseases Antibodies  >2 publications with PRCP and Kidney Diseases
 Shock Antibodies  >1 publications with PRCP and Shock
 Respiratory Tract Infections Antibodies  >1 publications with PRCP and Respiratory Tract Infections
 Arthritis, Rheumatoid Antibodies  >1 publications with PRCP and Arthritis, Rheumatoid

Organs/Tissues associated with anti-PRCP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >14 publications with PRCP and Blood
 Brain Antibodies  >14 publications with PRCP and Brain
 Vascular Antibodies  >10 publications with PRCP and Vascular
 Heart Antibodies  >4 publications with PRCP and Heart
 Embryonic Tissue Antibodies  >3 publications with PRCP and Embryonic Tissue
 Kidney Antibodies  >2 publications with PRCP and Kidney
 Thyroid Antibodies  >2 publications with PRCP and Thyroid
 Lung Antibodies  >2 publications with PRCP and Lung
 Liver Antibodies  >2 publications with PRCP and Liver
 Bone Antibodies  >2 publications with PRCP and Bone
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