Rabbit Anti-PSRC1 Polyclonal Antibody – Cat# MBS6338391

PSRC1 Antibody (C-Term) flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.

PSRC1 Antibody – Rabbit Polyclonal

Name: PSRC1 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6338391
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6338391

This gene encodes a proline-rich protein. Studies of this gene and the related mouse gene suggest that this gene is regulated by p53 and may participate in p53-mediated growth suppression. The encoded protein may function as a microtubule destabilizing… More details

$1060 / 0.2 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PSRC1, Polyclonal Antibody

Full Product Name

PSRC1, CT (PSRC1, DDA3, Proline/serine-rich coiled-coil protein 1) (PE)

Product Gene Name

anti-PSRC1 antibody

Product Synonym Names

PSRC1; DDA3; Proline/serine-rich coiled-coil protein 1

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: PE conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

35,632 Da

3D Structure

ModBase 3D Structure for Q6PGN9

Immunogen

PSRC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 343-371 amino acids from the C-terminal region of human PSRC1.

Conjugate

Note

Preservative Free

Special Handling

Light sensitive

Product Categories/Family for anti-PSRC1 antibody

Antibodies; CCDC (Coiled-coil Domain-containing)

Applications Tested/Suitable for anti-PSRC1 antibody

Flow Cytometry (FC/FACS), FLISA, Western Blot (WB)

Application Notes for anti-PSRC1 antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-PSRC1 antibody

Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Roder, C., et al. Childs Nerv Syst (2010). In press: Keebler, M.E., et al. Circ Cardiovasc Genet 3(4):358-364(2010). Hsieh, W.J., et al. Biochem. Biophys. Res. Commun. 369(2):567-572(2008).

Other Notes

Small volumes of anti-PSRC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PSRC1 purchase

MBS6338391 is an antibody targeting PSRC1. Also known as PSRC1, CT (PSRC1, DDA3, Proline/serine-rich coiled-coil protein 1) (PE). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PSRC1. It may not necessarily be applicable to this product.

NCBI GI #

73858561

NCBI GeneID

84722

NCBI Accession #

NP_001027462.1

NCBI Related Accession #

NP_116025.1; NP_001005290.1

UniProt Primary Accession #

Q6PGN9

UniProt Secondary Accession #

Q5T2Z3; Q6ZTI8; Q71MG3; Q9BV77

UniProt Related Accession #

Q6PGN9

GenBank Nucleotide #

NM_001032291.2

NCBI Official Full Name

proline/serine-rich coiled-coil protein 1 isoform a

NCBI Official Synonym Full Names

proline and serine rich coiled-coil 1

NCBI Official Symbol

PSRC1

NCBI Official Synonym Symbols

DDA3; FP3214

UniProt Protein Name

Proline/serine-rich coiled-coil protein 1

Protein Family

Proline/serine-rich coiled-coil protein

UniProt Gene Name

PSRC1

UniProt Synonym Gene Names

DDA3

NCBI Protein Information

proline/serine-rich coiled-coil protein 1

NCBI Summary for PSRC1

This gene encodes a proline-rich protein that is a target for regulation by the tumor suppressor protein p53. The encoded protein plays an important role in mitosis by recruiting and regulating microtubule depolymerases that destabalize microtubules. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Apr 2014]

UniProt Comments for PSRC1

Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression.

Research Articles on PSRC1

1. Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PSRC1 antibody

Reference Product	PubMed Publications
CELSR2 antibody	>21 publications with PSRC1 and CELSR2
SORT1 antibody	>16 publications with PSRC1 and SORT1

Diseases associated with anti-PSRC1 antibody

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>14 publications with PSRC1 and Cardiovascular Diseases
Heart Diseases Antibodies	>9 publications with PSRC1 and Heart Diseases
Neoplasms Antibodies	>5 publications with PSRC1 and Neoplasms
Arteriosclerosis Antibodies	>3 publications with PSRC1 and Arteriosclerosis
Liver Diseases Antibodies	>3 publications with PSRC1 and Liver Diseases
Nervous System Diseases Antibodies	>3 publications with PSRC1 and Nervous System Diseases
Lung Neoplasms Antibodies	>2 publications with PSRC1 and Lung Neoplasms
Liver Neoplasms Antibodies	>2 publications with PSRC1 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>2 publications with PSRC1 and Carcinoma, Hepatocellular
Kidney Neoplasms Antibodies	>1 publications with PSRC1 and Kidney Neoplasms

Organs/Tissues associated with anti-PSRC1 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with PSRC1 and Blood
Liver Antibodies	>4 publications with PSRC1 and Liver
Vascular Antibodies	>3 publications with PSRC1 and Vascular
Brain Antibodies	>3 publications with PSRC1 and Brain
Lung Antibodies	>2 publications with PSRC1 and Lung
Kidney Antibodies	>2 publications with PSRC1 and Kidney
Thymus Antibodies	>1 publications with PSRC1 and Thymus
Testis Antibodies	>1 publications with PSRC1 and Testis