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PYCR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6339340

PYCR2 belongs to the pyrroline-5-carboxylate reductase family. Pyrroline-5-carboxylate reductase catalyzes the the NAD(P)H-dependent conversion of proline to pyrroline-5-carboxylate. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PYCR2, Polyclonal Antibody
Full Product Name
PYCR2, ID (PYCR2, Pyrroline-5-carboxylate reductase 2) (Biotin)
Product Gene Name
anti-PYCR2 antibody
Product Synonym Names
PYCR2; Pyrroline-5-carboxylate reductase 2
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
3D Structure
ModBase 3D Structure for Q96C36
Immunogen
PYCR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human PYCR2.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-PYCR2 antibody

Antibodies; Enzymes; Reductase
Applications Tested/Suitable for anti-PYCR2 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-PYCR2 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PYCR2 antibody

PYCR2 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the PYCR2 antibody detected the PYCR2 protein (arrow).
Rabbit Anti-PYCR2 Polyclonal Antibody – Cat# MBS6339340

Immunohistochemistry (IHC) of anti-PYCR2 antibody

PYCR2 Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human placenta tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of PYCR2 Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-PYCR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6339340

Product References and Citations for anti-PYCR2 antibody

Lamesch, P., et al. Genomics 89(3):307-315(2007). Lim, J., et al. Cell 125(4):801-814(2006). Colland, F., et al. Genome Res. 14(7):1324-1332(2004).

Other Notes

Small volumes of anti-PYCR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PYCR2 purchase

MBS6339340 is an antibody targeting PYCR2. Also known as PYCR2, ID (PYCR2, Pyrroline-5-carboxylate reductase 2) (Biotin). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PYCR2. It may not necessarily be applicable to this product.

NCBI GI #
21361454
NCBI GeneID
29920
NCBI Accession #
NP_037460.2
UniProt Primary Accession #
Q96C36
UniProt Related Accession #
Q96C36
GenBank Nucleotide #
NP_037460.2
NCBI Official Full Name
pyrroline-5-carboxylate reductase 2 isoform 1
NCBI Official Synonym Full Names
pyrroline-5-carboxylate reductase 2
NCBI Official Symbol
PYCR2
NCBI Official Synonym Symbols
HLD10; P5CR2
UniProt Protein Name
Pyrroline-5-carboxylate reductase 2
Protein Family
Pyrroline-5-carboxylate reductase
UniProt Gene Name
PYCR2
UniProt Synonym Gene Names
P5C reductase 2; P5CR 2
UniProt Entry Name
P5CR2_HUMAN
NCBI Protein Information
pyrroline-5-carboxylate reductase 2

NCBI Summary for PYCR2

This gene belongs to the pyrroline-5-carboxylate reductase family. The encoded mitochondrial protein catalyzes the conversion of pyrroline-5-carboxylate to proline, which is the last step in proline biosynthesis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]
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UniProt Comments for PYCR2

PYCR2: Housekeeping enzyme that catalyzes the last step in proline biosynthesis. In some cell types, such as erythrocytes, its primary function may be the generation of NADP(+). Can utilize both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH. Belongs to the pyrroline-5-carboxylate reductase family.

Protein type: Amino Acid Metabolism - arginine and proline; Oxidoreductase; EC 1.5.1.2

Chromosomal Location of Human Ortholog: 1q42.12

Cellular Component: cytoplasm

Molecular Function: pyrroline-5-carboxylate reductase activity

Disease: Leukodystrophy, Hypomyelinating, 10
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Research Articles on PYCR2

1. PYCR2-related syndrome represents a clinically recognizable condition in which PYCR2 mutations lead to protein dysfunction.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PYCR2 antibody

 Reference Product  PubMed Publications
 METTL14 antibody  >1 publications with PYCR2 and METTL14

Pathways associated with anti-PYCR2 antibody

 Products by Pathway  Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Arginine And Proline Metabolism Pathway antibodies  Arginine And Proline Metabolism Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Biosynthesis Of Amino Acids Pathway antibodies  Biosynthesis Of Amino Acids Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Proline Biosynthesis, Glutamate => Proline Pathway antibodies  Proline Biosynthesis, Glutamate => Proline Pathway Diagram
 Proline Biosynthesis, Glutamate => Proline Pathway antibodies  Proline Biosynthesis, Glutamate => Proline Pathway Diagram

Organs/Tissues associated with anti-PYCR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >1 publications with PYCR2 and Embryonic Tissue
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