B2-Microglobulin (HLA-G) Protein

Name: HLA-G Protein; B2-Microglobulin; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS634471
Price: 705 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634471

Native beta-2 microglobulin is a component of MHC class I molecules, which are present on all nucleated cells. Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients. Also known as B2M, it has been suggested that… More details

$705 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

b2-Microglobulin (HLA-G), Protein

Full Product Name

b2-Microglobulin, Human (B2M, Beta 2 Microglobulin Precursor, Beta Chain of MHC Class 1 Proteins, HDCMA22P)

Product Gene Name

HLA-G protein

Form/Format

Purified; Human beta-2 microglobulin - lyophilised; Ammonium bicarbonate

Purity/Purification

>40% by SDS-PAGE

Preparation and Storage

Prior to reconstitution store at +4°C. After reconstitution store at -20°C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein.

Molecular Weight

12 kDa

Chromosome Location

Chromosome: 6; NC_000006.11 (29794756..29798899). Location: 6p21.3

OMIM

142871

3D Structure

ModBase 3D Structure for P17693

Product Type

Purified Protein

Target Species

Human

Reconstitution

Reconstitute with 1.0ml sterile PBS Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. It is recommended that the vial is gently mixed after reconstitution.

Preparation

Human beta-2 microglobulin was prepared from urine from patients with renal tubular proteinuria.

Product Categories/Family for HLA-G protein

Molecular Biology; MB-Serum Proteins

Applications Tested/Suitable for HLA-G protein

ELISA
Western Blotting (WB)

Application Notes for HLA-G protein

Where this product has not been tested for use in a particular technique this does not necessarily exclude its use in such procedures. Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own system using the appropriate negative/positive controls.

Other Notes

Small volumes of HLA-G protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HLA-G purchase

MBS634471 is a protein targeting HLA-G. Also known as b2-Microglobulin, Human (B2M, Beta 2 Microglobulin Precursor, Beta Chain of MHC Class 1 Proteins, HDCMA22P).

Additional Details

NCBI/Uniprot data below describe general gene information for HLA-G. It may not necessarily be applicable to this product.

NCBI GI #

188468

NCBI GeneID

3135

NCBI Accession #

AAA59836.1

UniProt Primary Accession #

P17693

UniProt Related Accession #

P17693

NCBI Official Full Name

b2 microglobulin

NCBI Official Synonym Full Names

major histocompatibility complex, class I, G

NCBI Official Symbol

HLA-G

NCBI Official Synonym Symbols

MHC-G

UniProt Protein Name

HLA class I histocompatibility antigen, alpha chain G

UniProt Synonym Protein Names

HLA G antigen; MHC class I antigen G

Protein Family

HLA class I histocompatibility antigen

UniProt Gene Name

HLA-G

UniProt Synonym Gene Names

HLA-6.0; HLAG

UniProt Entry Name

HLAG_HUMAN

NCBI Protein Information

HLA class I histocompatibility antigen, alpha chain G; HLA G antigen; b2 microglobulin; HLA class I molecule; MHC class I antigen G; HLA-G histocompatibility antigen, class I, G

NCBI Summary for HLA-G

HLA-G belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. HLA-G is expressed on fetal derived placental cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exon 6 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

UniProt Comments for HLA-G

HLA-G: Involved in the presentation of foreign antigens to the immune system. Plays a role in maternal tolerance of the fetus by mediating protection from the deleterious effects of natural killer cells, cytotoxic T-lymphocytes, macrophages and mononuclear cells. Belongs to the MHC class I family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 6p21.3

Cellular Component: Golgi membrane; phagocytic vesicle membrane; membrane; early endosome membrane; plasma membrane; MHC class I protein complex

Molecular Function: protein homodimerization activity; peptide antigen binding; receptor binding

Biological Process: immune response-inhibiting cell surface receptor signaling pathway; regulation of immune response; positive regulation of regulatory T cell differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of interleukin-12 production; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; cytokine and chemokine mediated signaling pathway; negative regulation of immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; positive regulation of tolerance induction; antigen processing and presentation of peptide antigen via MHC class I; negative regulation of T cell proliferation; antigen processing and presentation of exogenous peptide antigen via MHC class I; cellular defense response; positive regulation of T cell tolerance induction

Disease: Asthma, Susceptibility To

Research Articles on HLA-G

1. This meta-analysis suggests that the 14 bp insertion/deletion HLA-G allele is associated with increased risk of unexplained recurrent spontaneous abortion.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HLA-G protein

Reference Product	PubMed Publications
CD4 protein	>89 publications with HLA-G and CD4
IL10 protein	>75 publications with HLA-G and IL10
LILRB2 protein	>40 publications with HLA-G and LILRB2
KLRC1 protein	>11 publications with HLA-G and KLRC1
LIF protein	>11 publications with HLA-G and LIF
ADM2 protein	>2 publications with HLA-G and ADM2
SPRY2 protein	>1 publications with HLA-G and SPRY2

Pathways associated with HLA-G protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Allograft Rejection Pathway antibodies	Allograft Rejection Pathway Diagram
Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway antibodies	Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing And Presentation Pathway antibodies	Antigen Processing And Presentation Pathway Diagram
Antigen Processing-Cross Presentation Pathway antibodies	Antigen Processing-Cross Presentation Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Autoimmune Thyroid Disease Pathway antibodies	Autoimmune Thyroid Disease Pathway Diagram
Cell Adhesion Molecules (CAMs) Pathway antibodies	Cell Adhesion Molecules (CAMs) Pathway Diagram

Diseases associated with HLA-G protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>325 publications with HLA-G and Neoplasms
Adenocarcinoma Antibodies	>84 publications with HLA-G and Adenocarcinoma
Skin Diseases Antibodies	>63 publications with HLA-G and Skin Diseases
Inflammation Antibodies	>61 publications with HLA-G and Inflammation
Necrosis Antibodies	>43 publications with HLA-G and Necrosis
Nervous System Diseases Antibodies	>34 publications with HLA-G and Nervous System Diseases
Gastrointestinal Diseases Antibodies	>31 publications with HLA-G and Gastrointestinal Diseases
Asthma Antibodies	>27 publications with HLA-G and Asthma
Breast Neoplasms Antibodies	>24 publications with HLA-G and Breast Neoplasms
Cardiovascular Diseases Antibodies	>24 publications with HLA-G and Cardiovascular Diseases

Organs/Tissues associated with HLA-G protein

Organ/Tissue Name	Pubmed Publications
Placenta Antibodies	>442 publications with HLA-G and Placenta
Lung Antibodies	>33 publications with HLA-G and Lung
Brain Antibodies	>27 publications with HLA-G and Brain
Thymus Antibodies	>22 publications with HLA-G and Thymus
Stomach Antibodies	>8 publications with HLA-G and Stomach
Intestine Antibodies	>7 publications with HLA-G and Intestine
Testis Antibodies	>5 publications with HLA-G and Testis
Pancreas Antibodies	>3 publications with HLA-G and Pancreas