Fibronectin, Hamster (FN1) Protein

FN1: Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Defects in FN1 are the cause of glomerulopathy with fibronectin deposits type 2 (GFND2); also known as familial glomerular nephritis with fibronectin deposits or fibronectin glomerulopathy. GFND is a genetically heterogeneous autosomal dominant disorder characterized clinically by proteinuria, microscopic hematuria, and hypertension that leads to end-stage renal failure in the second to fifth decade of life. 15 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted; Cell adhesion

Cellular Component: extracellular matrix; extracellular space; proteinaceous extracellular matrix; apical plasma membrane; fibrinogen complex; ER-Golgi intermediate compartment; extracellular region; basement membrane; basal lamina

Molecular Function: heparin binding; integrin binding; protein binding; protease activator activity; protease binding; mercury ion binding

Biological Process: integrin activation; extracellular matrix organization and biogenesis; wound healing; positive regulation of chemotaxis; cell-matrix adhesion; positive regulation of axon extension; glial cell migration; regulation of cell shape; cell activation; cell-substrate junction assembly; acute-phase response; calcium-independent cell-matrix adhesion; peptide cross-linking; angiogenesis; cell adhesion; negative regulation of apoptosis; positive regulation of cell migration