Elastase, Porcine Protein

Elastase, like trypsin and chymotrypsin, is a serine protease that also hydrolyses amides and esters. It is produced in the pancreas as an inactive zymogen, proelastase, and activated in the duodenum by trypsin. Elastase is distinctive in that it acts upon elastin. Because elastin in found in highest concentrations in the elastic fibers of connective tissues, elastase is frequently used to dissociate tissues which contain extensive intercellular fiber networks. For this purpose, it is usually used with other enzymes such as collagenase, trypsin, and chymotrypsin. Elastase is the enzyme of choice for the isolation of Type II cells from the lung.

Elastase is also found in blood components. The serum enzyme, identical with pancreatic elastase, differs from the elastase of polymorphonuclear leukocytes. It is indicated that the leukocyte enzyme, which is inhibited by alpha1-antitrypsin but not by pancreatic trypsin inhibitor, mediates pathological elastolysis during acute arteritis and pulmonary emphysema. Bieth et al. (1974) indicate elastase involvement in atherosclerosis and acute hemorrhagic pancreatitis.

Small volumes of Elastase, Porcine protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS634677 is a protein targeting Elastase, Porcine. Host: Porcine pancreas.