Mouse SMOC1 Active Protein – Cat# MBS634838

SMOC1 Mouse Active Protein

Name: SMOC1 Active Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS634838
Price: 1105 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634838

SMOC-1 (secreted, or SPARC-related, modular calcium-binding protein 1) is a 70-90kD secreted glycoprotein that is a member of the SPARC family of matricellular molecules. Mature human SMOC-1 is 408aa in length. It contains one Kazal-like domain (aa42-87), two… More details

$1105 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SMOC1, Active Protein

Full Product Name

SMOC1 (SPARC-related Modular Calcium-binding Protein 1, Secreted Modular Calcium-binding Protein 1, SMOC-1)

Product Gene Name

SMOC1 active protein

Species Reactivity

Mouse

Form/Format

Supplied as a lyophilized powder from PBS. Reconstitute with sterile PBS.

Purity/Purification

Highly Purified
~95% (SDS-PAGE, reducing conditions)

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~48kD

Chromosome Location

Chromosome: 14; NC_000014.8 (70346105..70499083). Location: 14q24.2

OMIM

206920

3D Structure

ModBase 3D Structure for Q9H4F8

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity

Measured by the ability of the immobilized protein to support the adhesion of A431 human epidermoid carcinoma cells. When 5x10e4 cells/well are added to rmSMOC-1 coated plates, cell adhesion is enhanced in a dose dependent manner after 75 minutes at 37 degree C. The ED50 for this effect is typically 1-4ug/ml.

Endotoxin Level

1EU/1ug (LAL)

Product Categories/Family for SMOC1 active protein

Molecular Biology; MB-Proteins

Application Notes for SMOC1 active protein

SDS-PAGE: 60-65kD, reducing conditions

Other Notes

Small volumes of SMOC1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SMOC1 purchase

MBS634838 is an active protein targeting SMOC1. Also known as SMOC1 (SPARC-related Modular Calcium-binding Protein 1, Secreted Modular Calcium-binding Protein 1, SMOC-1). Reactive in Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for SMOC1. It may not necessarily be applicable to this product.

NCBI GI #

78190498

NCBI GeneID

64093

NCBI Accession #

NP_001030024.1

UniProt Primary Accession #

Q9H4F8

UniProt Secondary Accession #

Q96F78; A8K1S3; B2R7P5

UniProt Related Accession #

Q9H4F8

GenBank Nucleotide #

NM_001034852.2

NCBI Official Full Name

SPARC-related modular calcium-binding protein 1 isoform 1

NCBI Official Synonym Full Names

SPARC related modular calcium binding 1

NCBI Official Symbol

SMOC1

NCBI Official Synonym Symbols

OAS

UniProt Protein Name

SPARC-related modular calcium-binding protein 1

UniProt Synonym Protein Names

Secreted modular calcium-binding protein 1

Protein Family

UniProt Gene Name

SMOC1

UniProt Synonym Gene Names

SMOC-1

UniProt Entry Name

SMOC1_HUMAN

NCBI Protein Information

SPARC-related modular calcium-binding protein 1; secreted modular calcium-binding protein 1

NCBI Summary for SMOC1

This gene encodes a multi-domain secreted protein that may have a critical role in ocular and limb development. Mutations in this gene are associated with microphthalmia and limb anomalies. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]

UniProt Comments for SMOC1

SMOC1: Plays essential roles in both eye and limb development. Probale regulator of osteoblast differentiation. Defects in SMOC1 are the cause of ophthalmoacromelic syndrome (OAS). A rare disorder presenting with anophthalmia or microphthalmia and limb anomalies. Limb malformations include fused 4th and 5th metacarpals and short 5th finger in hands, and olygodactyly in foot (four toes). Most patients have bilateral anophthalmia/ microphthalmia, but unilateral abnormality is also noted. Other malformations are rare, but venous or vertebral anomaly was recognized each in single cases. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 14q24.2

Cellular Component: basement membrane

Molecular Function: protein binding; extracellular matrix binding; calcium ion binding

Biological Process: limb development; extracellular matrix organization and biogenesis; regulation of osteoblast differentiation; eye development; cell differentiation; signal transduction

Disease: Microphthalmia With Limb Anomalies

Research Articles on SMOC1

1. IL-17A but not IL-22 suppresses the replication of hepatitis B virus by inducing the expression of MxA and OAS.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with SMOC1 active protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>4 publications with SMOC1 and Congenital Abnormalities
Neoplasms Antibodies	>3 publications with SMOC1 and Neoplasms
Atrophy Antibodies	>1 publications with SMOC1 and Atrophy
Fibrosis Antibodies	>1 publications with SMOC1 and Fibrosis
Kidney Diseases Antibodies	>1 publications with SMOC1 and Kidney Diseases
Disease Models, Animal Antibodies	>1 publications with SMOC1 and Disease Models, Animal
Necrosis Antibodies	>1 publications with SMOC1 and Necrosis

Organs/Tissues associated with SMOC1 active protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>5 publications with SMOC1 and Eye
Kidney Antibodies	>4 publications with SMOC1 and Kidney
Bone Antibodies	>3 publications with SMOC1 and Bone
Brain Antibodies	>3 publications with SMOC1 and Brain
Embryonic Tissue Antibodies	>2 publications with SMOC1 and Embryonic Tissue
Bone Marrow Antibodies	>2 publications with SMOC1 and Bone Marrow
Ovary Antibodies	>2 publications with SMOC1 and Ovary
Muscle Antibodies	>1 publications with SMOC1 and Muscle
Connective Tissue Antibodies	>1 publications with SMOC1 and Connective Tissue
Prostate Antibodies	>1 publications with SMOC1 and Prostate