Interferon-Inducible T Cell Alpha Chemoattractant, Murine (CXCL11) Active Protein

Name: CXCL11 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS634865
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634865

Murine Interferon-inducible T cell alpha chemoattractant (I-TAC) is a novel non-ELR CXC chemokine. Murine I-TAC is regulated by interferon and has potent chemoattractant activity for IL-2 activated T cells, but not for freshly isolated unstimulated T cells,… More details

$370 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interferon-inducible T Cell Alpha Chemoattractant, Murine (Cxcl11), Active Protein

Full Product Name

Interferon-inducible T Cell Alpha Chemoattractant, Murine (I-TAC)

Product Gene Name

Cxcl11 active protein

Sequence

FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRKQNM

Host

E Coli

Form/Format

Sterile filtered and lyophilized without additives.

Purity/Purification

Molecular Biology Grade
98% by SDS-PAGE and HPLC analysis.

Preparation and Storage

-20 degree C
Stability: Lyophilized protein, though stable at room temperature, is best stored desiccated below 0 degree C. Reconstituted I-TAC should be stored in working aliquots at-20 degree C.

Molecular Weight

9.0kD

Chromosome Location

Chromosome: 5; NC_000071.6 (92359544..92363296, complement). Location: 5; 5 E3

3D Structure

ModBase 3D Structure for Q9JHH5

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Determined by its ability to chemoattract murine CXCR3 transfected HEK/293 cells using a concentration range of 10-100ng/ml.

Country of Origin

USA

Endotoxin Level

0.1ng/ug (1EU/ug)

Reconstitution

Lyophilized human I-TAC is soluble in water and most aqueous buffers and can be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted into other buffered solutions or stored frozen for future use.

Product Categories/Family for Cxcl11 active protein

Growth Factors; Cytokines; Growth Factors-I-TAC

Other Notes

Small volumes of Cxcl11 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cxcl11 purchase

MBS634865 is an active protein targeting Cxcl11. Also known as Interferon-inducible T Cell Alpha Chemoattractant, Murine (I-TAC). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Cxcl11. It may not necessarily be applicable to this product.

NCBI GI #

8572623

NCBI GeneID

56066

NCBI Accession #

AAF77095.1

UniProt Primary Accession #

Q9JHH5

UniProt Related Accession #

Q9JHH5

NCBI Official Full Name

interferon-inducible T cell alpha chemoattractant proprotein

NCBI Official Synonym Full Names

chemokine (C-X-C motif) ligand 11

NCBI Official Symbol

Cxcl11

NCBI Official Synonym Symbols

Ip9; H174; Itac; b-R1; Cxc11; I-tac; Scyb11; Scyb9b; betaR1

UniProt Protein Name

C-X-C motif chemokine 11

UniProt Synonym Protein Names

Interferon-inducible T-cell alpha chemoattractant; I-TAC; Small-inducible cytokine B11

Protein Family

C-X-C motif chemokine

UniProt Gene Name

Cxcl11

UniProt Synonym Gene Names

Scyb11; I-TAC

UniProt Entry Name

CXL11_MOUSE

NCBI Protein Information

C-X-C motif chemokine 11; small-inducible cytokine B11; interferon-inducible T-cell alpha chemoattractant; small inducible cytokine subfamily B (Cys-X-Cys), member 11

UniProt Comments for Cxcl11

CXCL11: Chemotactic for interleukin-activated T-cells but not unstimulated T-cells, neutrophils or monocytes. Induces calcium release in activated T-cells. Binds to CXCR3. May play an important role in CNS diseases which involve T-cell recruitment. May play a role in skin immune responses. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; extracellular region

Molecular Function: CXCR3 chemokine receptor binding; chemokine activity; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; immune response; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; inflammatory response; chemotaxis; regulation of cell proliferation

Research Articles on Cxcl11

1. Cxcl10 and cxcl11 are new hair-specific transcriptional targets of ectodysplasin, and they indicates involvement of chemokines in hair development.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Cxcl11 active protein

Products by Pathway	Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Toll-like Receptor Signaling Pathway antibodies	Toll-like Receptor Signaling Pathway Diagram
Toll-like Receptor Signaling Pathway antibodies	Toll-like Receptor Signaling Pathway Diagram

Diseases associated with Cxcl11 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>160 publications with Cxcl11 and Inflammation
Neoplasms Antibodies	>86 publications with Cxcl11 and Neoplasms
Necrosis Antibodies	>66 publications with Cxcl11 and Necrosis
Lung Diseases Antibodies	>52 publications with Cxcl11 and Lung Diseases
Disease Models, Animal Antibodies	>49 publications with Cxcl11 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>28 publications with Cxcl11 and Cardiovascular Diseases
Liver Diseases Antibodies	>28 publications with Cxcl11 and Liver Diseases
Fibrosis Antibodies	>22 publications with Cxcl11 and Fibrosis
Kidney Diseases Antibodies	>19 publications with Cxcl11 and Kidney Diseases
Adenocarcinoma Antibodies	>15 publications with Cxcl11 and Adenocarcinoma

Organs/Tissues associated with Cxcl11 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>312 publications with Cxcl11 and Blood
Lung Antibodies	>76 publications with Cxcl11 and Lung
Liver Antibodies	>36 publications with Cxcl11 and Liver
Brain Antibodies	>29 publications with Cxcl11 and Brain
Kidney Antibodies	>27 publications with Cxcl11 and Kidney
Spleen Antibodies	>23 publications with Cxcl11 and Spleen
Eye Antibodies	>21 publications with Cxcl11 and Eye
Bone Marrow Antibodies	>21 publications with Cxcl11 and Bone Marrow
Thymus Antibodies	>9 publications with Cxcl11 and Thymus
Bladder Antibodies	>2 publications with Cxcl11 and Bladder