ICOS Ligand IgG2a Fc Fusion Protein (ICOS) Protein

The inducible costimulator CD278 (ICOS) is similar to human CD28 (24% homology), and plays an analogous role in the T cell activation process. Unlike CD28, CD278 is only expressed on activated T cells. Secondary signaling through CD28 or CD278 results in discrete cytokine secretion profiles by the activated T cells (1). Engagement of CD152 (CTLA-4) anergizes cells costimulated with either CD28 and CD278 (2). Signaling through CD278 is particularly important in progression of TH2 immune response (5). The receptor for human CD278 (ICOS) is CD275 (GL50, ICOS L), a member of the B7 family sharing ~20% homology with CD80 (B7-1) and CD86 (B7-2) (3). Two RNA splice variants exist for this molecule, differing only in the cytoplasmic domain (4). Blockade of the CD278-CD275 interaction in mice improves allograft survival (6) and reduces EAE (7).

Small volumes of ICOS Ligand IgG2a Fc Fusion Protein protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS634872 is a protein targeting ICOS Ligand IgG2a Fc Fusion Protein. Also known as ICOS Ligand, Mouse IgG2a Fc Fusion Protein (Inducible T-cell Co-stimulator Ligand, ICOSL, ICOS-L, ICOSLG, B7 Homolog 2, B7H2, B7-H2, B7-like Protein Gl50, B7-related Protein 1, B7RP1, B7RP-1, CD275, GL50, KIAA0653, LICOS) (Biotin).