Neuropeptide Y Y2 Receptor (NPY2R) Protein

Name: NPY2R Protein; Neuropeptide Y Y2 Receptor; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS634992
Price: 355 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634992

MBS634992 is a protein targeting NPY2R. Also known as Neuropeptide Y Y2 Receptor (NPY Y2R). Host: Synthetic. More details

$355 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neuropeptide Y Y2 Receptor (NPY2R), Protein

Full Product Name

Neuropeptide Y Y2 Receptor (NPY Y2R)

Product Gene Name

NPY2R protein

Host

Synthetic

Form/Format

Supplied as a lyophilized powder.

Purity/Purification

Purified - 94.15% (HPLC)

Preparation and Storage

Lyophilized powder may be stored at 4°C for short-term only. Stable for up to 6 months at -20°C. Reconstitute (see reconstitution instructions for peptides) and store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

1173.28

Chromosome Location

Chromosome: 4; NC_000004.11 (156094924..156138248). Location: 4q31

OMIM

162642

3D Structure

ModBase 3D Structure for P49146

Sequence (linear)

(C)TDSFSEATNV-COOH

Molecular Formula

C₄₇H₇₂N₁₂O₂₁S₁

Product Categories/Family for NPY2R protein

Molecular Biology; MB-Receptors

Other Notes

Small volumes of NPY2R protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NPY2R. It may not necessarily be applicable to this product.

NCBI GI #

29824918

NCBI GeneID

4887

NCBI Accession #

AAO92062.1

UniProt Primary Accession #

P49146

UniProt Secondary Accession #

Q13281; Q13457; Q4W5G7; Q6AZZ6; Q9UE67

UniProt Related Accession #

P49146

NCBI Official Full Name

neuropeptide Y receptor Y2

NCBI Official Synonym Full Names

neuropeptide Y receptor Y2

NCBI Official Symbol

NPY2R

NCBI Official Synonym Symbols

NPY2-R

UniProt Protein Name

Neuropeptide Y receptor type 2

UniProt Synonym Protein Names

NPY-Y2 receptor

Protein Family

Neuropeptide Y receptor

UniProt Gene Name

NPY2R

UniProt Synonym Gene Names

NPY2-R; Y2 receptor

UniProt Entry Name

NPY2R_HUMAN

NCBI Protein Information

neuropeptide Y receptor type 2; Y2 receptor; NPY-Y2 receptor

UniProt Comments for NPY2R

NPY2R: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: integral to plasma membrane; nonmotile primary cilium; plasma membrane

Molecular Function: peptide YY receptor activity; protein binding; calcium channel regulator activity; neuropeptide Y receptor activity; receptor activity

Biological Process: positive regulation of dopamine secretion; secretion; positive regulation of cell adhesion; behavioral fear response; negative regulation of synaptic transmission, glutamatergic; locomotory behavior; positive regulation of peptide secretion; negative regulation of cAMP biosynthetic process; elevation of cytosolic calcium ion concentration; neuropeptide signaling pathway; negative regulation of secretion; G-protein signaling, adenylate cyclase inhibiting pathway; positive regulation of smooth muscle contraction; regulation of sensory perception of pain; nitric oxide mediated signal transduction; negative regulation of neurological process; positive regulation of circadian sleep/wake cycle, non-REM sleep

Research Articles on NPY2R

1. this study concludes that common genetic variation in the proximal NPY2R promoter influences transcription factor binding so as to alter gene expression in neuroendocrine cells, and consequently cardiometabolic traits in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NPY2R protein

Reference Product	PubMed Publications
NPY protein	>13 publications with NPY2R and NPY
NPY5R protein	>9 publications with NPY2R and NPY5R
PYY protein	>6 publications with NPY2R and PYY
PPY protein	>2 publications with NPY2R and PPY
POMC protein	>1 publications with NPY2R and POMC

Pathways associated with NPY2R protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide GPCRs Pathway antibodies	Peptide GPCRs Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with NPY2R protein

Disease Name	Pubmed Publications
Hypertension Antibodies	>2 publications with NPY2R and Hypertension
Mental Disorders Antibodies	>2 publications with NPY2R and Mental Disorders
Alcoholism Antibodies	>2 publications with NPY2R and Alcoholism
Weight Gain Antibodies	>1 publications with NPY2R and Weight Gain
Hypertrophy Antibodies	>1 publications with NPY2R and Hypertrophy
Cardiomegaly Antibodies	>1 publications with NPY2R and Cardiomegaly
Neurobehavioral Manifestations Antibodies	>1 publications with NPY2R and Neurobehavioral Manifestations
Substance Withdrawal Syndrome Antibodies	>1 publications with NPY2R and Substance Withdrawal Syndrome
Cocaine-Related Disorders Antibodies	>1 publications with NPY2R and Cocaine-Related Disorders

Organs/Tissues associated with NPY2R protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with NPY2R and Brain
Nerve Antibodies	>1 publications with NPY2R and Nerve