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Transferrin, Rat (TFRC) Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635033

Transferrin is a single polypeptide chain glycoprotein and is a member of the iron binding family of proteins. It has a molecular weight of 79.5kD and a serum concentration range of 1800-2700mg/L. It is synthesized in the liver and consists of two domains… More details

$830 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transferrin, Rat (Tfrc), Protein
Full Product Name
Transferrin, Rat (Tf)
Product Gene Name
Tfrc protein
Form/Format
Supplied as a liquid in PBS, pH 7.6. No preservative and no stabilizing proteins added.
Purity/Purification
Highly Purified
Purified by ion exchange chromatography. IEP Assay shows a single precipitin arc against anti-rat Transferrin and anti-rat serum. Iron saturated (HOLO).
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Certificate of Origin The raw animal product used in the manufacturing of Transferrin, Rat is derived from starting materials of North American origin. Collection was performed in USDA-inspected facilities and all materials have been inspected and certified to be free of disease and suitable for exportation.
Molecular Weight
70,153 Da
Chromosome Location
Chromosome: 11; NC_005110.3 (74479841..74502561, complement). Location: 11q22
3D Structure
ModBase 3D Structure for Q99376

Product Categories/Family for Tfrc protein

Molecular Biology; MB-Transferrin
Applications Tested/Suitable for Tfrc protein
ELISA (EL/EIA)
Application Notes for Tfrc protein
Suitable for use in Immunochemical reactions, as a control or standard in assays, conjugation, and most Immunological methods that requires highly purified proteins. Other applications not tested

Testing Data of Tfrc protein

Transferin, TF, Apotransferrin, Beta-1 Metal-binding Globulin, DKFZp781D0156, PRO1400, PRO1557, PRO2086, Serotransferrin Precursor, Siderophilin
TFRC Protein – Cat# MBS635033

Other Notes

Small volumes of Tfrc protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Tfrc purchase

MBS635033 is a protein targeting Tfrc. Also known as Transferrin, Rat (Tf).

Additional Details

NCBI/Uniprot data below describe general gene information for Tfrc. It may not necessarily be applicable to this product.

NCBI GI #
281306746
NCBI GeneID
64678
NCBI Accession #
NP_073203.1
UniProt Primary Accession #
Q99376
UniProt Related Accession #
Q99376
GenBank Nucleotide #
NM_022712.1
NCBI Official Full Name
transferrin receptor protein 1
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
Tfrc
NCBI Official Synonym Symbols
Trfr
UniProt Protein Name
Transferrin receptor protein 1
Protein Family
Transferrin receptor protein
UniProt Gene Name
Tfrc
UniProt Synonym Gene Names
Trfr; TR; TfR; TfR1; Trfr
UniProt Entry Name
TFR1_RAT
NCBI Protein Information
transferrin receptor protein 1; TR; tfR; tfR1

NCBI Summary for Tfrc

receptor for transferrin; involved in regulating stellate cell activation [RGD, Feb 2006]

UniProt Comments for Tfrc

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Receptor, misc.; Membrane protein, integral; Cell surface

Cellular Component: extracellular space; cell surface; mitochondrion; intracellular membrane-bound organelle; cell; recycling endosome membrane; cytoplasmic membrane-bound vesicle; extracellular region; integral to membrane; coated pit; recycling endosome; perinuclear region of cytoplasm; plasma membrane; melanosome; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; transferrin receptor activity; chaperone binding; double-stranded RNA binding; Hsp70 protein binding

Biological Process: receptor-mediated endocytosis; response to retinoic acid; response to inorganic substance; cellular iron ion homeostasis; transferrin transport; osteoclast differentiation; regulation of cell proliferation; response to manganese ion; response to organic substance; response to copper ion; acute-phase response; response to hypoxia; positive regulation of bone resorption; regulation of cell growth; response to iron ion; response to nutrient; aging
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Research Articles on Tfrc

1. Whole-genome profiling reveals that increasing dietary protein from 5 to 40% increass duodenal transcript expression of divalent metal transporter 1 (DMT1) 3.2-fold, duodenal cytochrome b (Dcytb) 1.8-fold, and transferrin receptor (TfR) 1.8-fold.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Tfrc protein

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Uptake And Transport Pathway antibodies  Iron Uptake And Transport Pathway Diagram
 Membrane Trafficking Pathway antibodies  Membrane Trafficking Pathway Diagram
 Phagosome Pathway antibodies  Phagosome Pathway Diagram

Organs/Tissues associated with Tfrc protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >22 publications with Tfrc and Liver
 Brain Antibodies  >17 publications with Tfrc and Brain
 Lung Antibodies  >12 publications with Tfrc and Lung
 Kidney Antibodies  >7 publications with Tfrc and Kidney
 Prostate Antibodies  >5 publications with Tfrc and Prostate
 Heart Antibodies  >4 publications with Tfrc and Heart
 Small Intestine Antibodies  >4 publications with Tfrc and Small Intestine
 Eye Antibodies  >3 publications with Tfrc and Eye
 Connective Tissue Antibodies  >2 publications with Tfrc and Connective Tissue
 Placenta Antibodies  >2 publications with Tfrc and Placenta
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