SERPIND1 Active Protein – Cat# MBS635071

Heparin Cofactor II (SERPIND1) Active Protein

Name: SERPIND1 Active Protein; Heparin Cofactor II; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS635071
Price: 1195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635071

Inhibition of Thrombin by Heparin Cofactor II: Thrombin (IIa), heparin (HEP) and heparin cofactor II (HCII) interact to form a ternary complex via a random order bireactant mechanism. Heparin subsequently dissociates from the complex as thrombin forms a… More details

$1195 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Heparin Cofactor II (SERPIND1), Active Protein

Full Product Name

Heparin Cofactor II, Human (HCII)

Product Gene Name

SERPIND1 active protein

Host

Human plasma

Form/Format

Supplied as a liquid in 50% glycerol/H2O.

Purity/Purification

Highly Purified
Heparin cofactor II is prepared from fresh frozen plasma by a modification of the procedure of Griffith, et al., (9). Purity is 95% by SDS PAGE and activity is determined based on thrombin inhibition in the presence of dermatan sulfate.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

65,600

Chromosome Location

Chromosome: 22; NC_000022.10 (21128383..21142008). Location: 22q11.21

OMIM

142360

3D Structure

ModBase 3D Structure for P05546

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Specific Activity

~730U/mg; One unit will inhibit one NIH unit of thrombin.

Product Categories/Family for SERPIND1 active protein

Molecular Biology; MB-Coagulation Factors

Other Notes

Small volumes of SERPIND1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SERPIND1 purchase

MBS635071 is an active protein targeting SERPIND1. Also known as Heparin Cofactor II, Human (HCII). Host: Human plasma.

Additional Details

NCBI/Uniprot data below describe general gene information for SERPIND1. It may not necessarily be applicable to this product.

NCBI GI #

183910

NCBI GeneID

3053

NCBI Accession #

AAA52642.1

UniProt Primary Accession #

P05546

UniProt Secondary Accession #

Q6IBZ5; B2RAI1; D3DX34

UniProt Related Accession #

P05546

NCBI Official Full Name

heparin cofactor II

NCBI Official Synonym Full Names

serpin peptidase inhibitor, clade D (heparin cofactor), member 1

NCBI Official Symbol

SERPIND1

NCBI Official Synonym Symbols

HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673

UniProt Protein Name

Heparin cofactor 2

UniProt Synonym Protein Names

Heparin cofactor II; HC-II; Protease inhibitor leuserpin-2; HLS2; Serpin D1

Protein Family

Heparin cofactor

UniProt Gene Name

SERPIND1

UniProt Synonym Gene Names

HCF2; HC-II; HLS2

UniProt Entry Name

HEP2_HUMAN

NCBI Protein Information

heparin cofactor 2; serpin D1; leuserpin 2; protease inhibitor leuserpin-2; serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1

NCBI Summary for SERPIND1

The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. [provided by RefSeq, Jul 2008]

UniProt Comments for SERPIND1

SERPIND1: Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). Also inhibits chymotrypsin, but in a glycosaminoglycan-independent manner. Defects in SERPIND1 are the cause of thrombophilia due to heparin cofactor 2 deficiency (THPH10). A hemostatic disorder characterized by a tendency to recurrent thrombosis. Belongs to the serpin family.

Chromosomal Location of Human Ortholog: 22q11.21

Cellular Component: extracellular space; extracellular region

Molecular Function: serine-type endopeptidase inhibitor activity; heparin binding; endopeptidase inhibitor activity

Biological Process: chemotaxis; blood coagulation

Disease: Heparin Cofactor Ii Deficiency

Research Articles on SERPIND1

1. In this study, we demonstrate a previously unknown role for HCII in host defense.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SERPIND1 active protein

Reference Product	PubMed Publications
SERPINC1 active protein	>2 publications with SERPIND1 and SERPINC1
PROC active protein	>1 publications with SERPIND1 and PROC

Pathways associated with SERPIND1 active protein

Products by Pathway	Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram

Diseases associated with SERPIND1 active protein

Disease Name	Pubmed Publications
Atherosclerosis Antibodies	>3 publications with SERPIND1 and Atherosclerosis
Death Antibodies	>1 publications with SERPIND1 and Death
Heart Diseases Antibodies	>1 publications with SERPIND1 and Heart Diseases
Liver Diseases Antibodies	>1 publications with SERPIND1 and Liver Diseases
Hyperplasia Antibodies	>1 publications with SERPIND1 and Hyperplasia
Necrosis Antibodies	>1 publications with SERPIND1 and Necrosis
Heparin Cofactor II Deficiency Antibodies	>1 publications with SERPIND1 and Heparin Cofactor II Deficiency

Organs/Tissues associated with SERPIND1 active protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>5 publications with SERPIND1 and Liver
Vascular Antibodies	>3 publications with SERPIND1 and Vascular
Kidney Antibodies	>1 publications with SERPIND1 and Kidney
Lung Antibodies	>1 publications with SERPIND1 and Lung