Thymus-Expressed Chemokine (CCL25) Active Protein

Name: CCL25 Active Protein; Thymus-Expressed Chemokine; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS635072
Price: 370 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635072

Human thymus-expressed chemokine (TECK), a 14.2kD protein containing 127 amino acid residues, is a novel CC chemokine that was identified in the thymus of mouse and human. TECK shows chemotactic activity for activated macrophages, dendritic cells and… More details

$370 / 0.005 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Thymus-expressed Chemokine (Ccl25), Active Protein

Full Product Name

Thymus-expressed Chemokine, Human (TECK)

Product Gene Name

Ccl25 active protein

Host

E Coli

Form/Format

Sterile filtered and lyophilized without additives.

Purity/Purification

Molecular Biology Grade
98% by SDS-PAGE and HPLC analysis.

Preparation and Storage

-20 degree C
Stability: Lyophilized protein, though stable at room temperature, is best stored desiccated below 0 degree C. Reconstituted TECK should be stored in working aliquots at -20 degree C.

Molecular Weight

14.2kD

Chromosome Location

Chromosome: 8; NC_000074.6 (4325210..4360020). Location: 8 A1.1; 8 2.01 cM

3D Structure

ModBase 3D Structure for Q9QYY6

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

The biological activity of human TECK was determined by a chemotaxis assay using human monocytes. Significant chemotaxis was achieved at a concentration range of 1.0-10.0 ng/ml.

Endotoxin Level

0.1 ng/ug (1EU/ug)

Reconstitution

Lyophilized human TECK is soluble in water and most aqueous buffers and can be reconstituted in water to a concentration of 0.1-1.0mg/ml. This solution can be diluted into other buffered solutions or stored frozen for future use.

Product Categories/Family for Ccl25 active protein

Growth Factors; Cytokines; Growth Factors-TECK

Other Notes

Small volumes of Ccl25 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ccl25 purchase

MBS635072 is an active protein targeting Ccl25. Also known as Thymus-expressed Chemokine, Human (TECK). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for Ccl25. It may not necessarily be applicable to this product.

NCBI GI #

5881909

NCBI GeneID

20300

NCBI Accession #

CAB55762.1

UniProt Primary Accession #

Q9QYY6

UniProt Secondary Accession #

Q9QYY6

UniProt Related Accession #

O35903

NCBI Official Full Name

thymus-expressed chemokine

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 25

NCBI Official Symbol

Ccl25

NCBI Official Synonym Symbols

TECK; CKb15; Scya25; AI852536; A130072A22Rik

UniProt Protein Name

C-C motif chemokine 25

UniProt Synonym Protein Names

Chemokine TECK; Small-inducible cytokine A25; Thymus-expressed chemokine

Protein Family

C-C motif chemokine

UniProt Gene Name

Ccl25

UniProt Synonym Gene Names

Scya25; Teck

UniProt Entry Name

CCL25_MOUSE

NCBI Protein Information

C-C motif chemokine 25; thymus-expressed chemokine; small inducible chemokine 25; small inducible cytokine A25

UniProt Comments for Ccl25

CCL25: Potentially involved in T-cell development. Recombinant protein shows chemotactic activity on thymocytes, macrophages, THP-1 cells, and dendritics cells but is inactive on peripheral blood lymphocytes and neutrophils. Binds to CCR9. Isoform 2 is an antagonist of isoform 1. Belongs to the intercrine beta (chemokine CC) family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Chemokine; Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; cytokine activity

Biological Process: G-protein coupled receptor protein signaling pathway; immune response; chemotaxis; positive regulation of cell-matrix adhesion; inflammatory response; leukocyte migration

Research Articles on Ccl25

1. Accumulated CD11b(+) macrophages are critical for activating hepatic stellate cells through the CCR9/CCL25 axis and therefore promote liver fibrosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Ccl25 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with Ccl25 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>51 publications with Ccl25 and Inflammation
Gastrointestinal Diseases Antibodies	>33 publications with Ccl25 and Gastrointestinal Diseases
Neoplasms Antibodies	>24 publications with Ccl25 and Neoplasms
Necrosis Antibodies	>22 publications with Ccl25 and Necrosis
Neoplasm Metastasis Antibodies	>11 publications with Ccl25 and Neoplasm Metastasis
Liver Diseases Antibodies	>10 publications with Ccl25 and Liver Diseases
Lymphoma Antibodies	>7 publications with Ccl25 and Lymphoma
Carcinoma Antibodies	>7 publications with Ccl25 and Carcinoma
Atrophy Antibodies	>5 publications with Ccl25 and Atrophy
Neoplasms, Experimental Antibodies	>4 publications with Ccl25 and Neoplasms, Experimental

Organs/Tissues associated with Ccl25 active protein

Organ/Tissue Name	Pubmed Publications
Intestine Antibodies	>83 publications with Ccl25 and Intestine
Thymus Antibodies	>80 publications with Ccl25 and Thymus
Lymph Node Antibodies	>33 publications with Ccl25 and Lymph Node
Skin Antibodies	>15 publications with Ccl25 and Skin
Embryonic Tissue Antibodies	>11 publications with Ccl25 and Embryonic Tissue
Mammary Gland Antibodies	>3 publications with Ccl25 and Mammary Gland
Brain Antibodies	>3 publications with Ccl25 and Brain
Eye Antibodies	>1 publications with Ccl25 and Eye
Testis Antibodies	>1 publications with Ccl25 and Testis