Interleukin 22 Binding Protein, Fc Chimera Active Protein

Human IL-22BP/Fc Chimera Interleukin 22 binding protein (IL-22BP), also known as cytokine receptor family (CRF) 2-10, CRF2-X, and IL-22 RA2, is a secreted glycoprotein belonging to the type II cytokine receptor family. The IL-22BP gene has been localized to chromosome 6 near the gene for IFN-£^ R1. It encodes a precursor protein of 231 amino acid (aa) residues with a 21 aa putative signal peptide and five potential N-linked glycolsylation sites. IL-22BP lacks a transmembrane and cytoplasmic domain and is most closely related to the extracellular domains of IL-22R (CRF2-9) and IL-20R (CRF2-8), sharing 33% and 34% aa sequence identity, respectively. It also shares sequence homology with the extracellular domains of IL-10R (29%), IL-10 Rb (30%), the IFN receptors (23-25%) and tissue factor (26%). IL-22BP antagonizes IL-22 activity by specifically binding IL-22 with high affinity and blocking its interaction with the cell surface IL-22 receptor heteromeric complex composed IL-22R and IL-20R. IL-22BP is expressed in multiple tissues. The

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MBS635216 is an active protein targeting Interleukin 22 Binding Protein, Fc Chimera. Also known as Interleukin 22 Binding Protein, Fc Chimera, Human (IL-22BP, Cytokine Receptor Family (CRF) 2-10, CRF2-X, IL-22 RA2).