Plasminogen Activator Inhibitor Type 1, Mutant, Active Wild Type Protein

Plasminogen Activator Inhibitor 1 (PAI-1) is a glycoprotein found in plasma that is implicated in the processes of angiogenesis, hemostasis, tumor metastasis, fibrionlysis, ovulation, embryonic development and inflammation (1). The elevation of PAI-1 has shown to correlate with the prognosis of many cancers including breast cancer (2,3,4). PAI-1 is activated by the glycoprotein vitronectin. Vitronectin binds to PAI-1 and modulates fibrinolysis and cell migration (5). This binding has proven to be an important inhibitor of the activated form of protein C (APC) (6).

Small volumes of Plasminogen Activator Inhibitor Type 1, mutant, active wild type protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS635245 is a protein targeting Plasminogen Activator Inhibitor Type 1, mutant, active wild type. Also known as Plasminogen Activator Inhibitor Type 1, Human, mutant, active wild type (PAI-1).