CRIM1 Active Protein

Cysteine rich motor neuron 1 (CRIM1) is a type I transmembrane glycoprotein of the chordin-like cysteine-rich repeat (CRR) family of BMP inhibitors. The ~130kD, 1036aa CRIM1 contains a 34aa signal sequence, a 905aa extracellular domain (ECD), a 21aa transmembrane domain and a 76aa cytoplasmic domain. The ECD includes an N-terminal IGF-binding protein-like motif and six chordin-like von Willebrand C-type CRRs. The ECD can be released from the cell, presumably by proteolytic processing. Human CRIM1 ECD shows 88%, 88%, 91%, 86%, 87%, 83% and 72% aa identity with mouse, rat, dog, cow, opossum, chick and zebrafish CRIM1 ECD, respectively. CRIM1 can interact with TGF-beta family ligands, including BMPs 2, 4 and 7, via its CRR domains. It binds BMPs intracellularly and antagonizes them by lowering their expression, processing and secretion. CRIM1 is expressed in the developing spinal cord in the floor plate and developing motor neurons. It is also expressed by perivascular smooth muscle cells and aligns at points of cell-cell contact during endothelial cell capillary formation. Endothelial cell expression in vitro appears to be specific to cells that are adherent and growing. CRIM1 is also expressed in a spatially and temporally restricted manner in the developing lens, limbs, kidney, teeth and testis. Studies where CRIM1 expression is manipulated in developing mouse, chick and zebrafish support its involvement in regulation of vascular and somitic development and organogenesis.

Small volumes of CRIM1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS635530 is an active protein targeting CRIM1. Also known as CRIM1, Recombinant, Human (Cysteine-rich motor neuron 1 protein).