Glutathione S Transferase, T1-1 Human (GSTT1) Active Protein

Name: GSTT1 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS635557
Price: 910 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635557

MBS635557 is an active protein targeting GSTT1. Also known as Glutathione S Transferase, T1-1, Recombinant Human (GST). More details

$910 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glutathione S Transferase, T1-1 Human (GSTT1), Active Protein

Full Product Name

Glutathione S Transferase, T1-1, Recombinant Human (GST)

Product Gene Name

GSTT1 active protein

Form/Format

Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 50mM sodium chloride, 1mM DTT, 5mM EDTA and 50% glycerol.

Purity/Purification

~95% (SDS-PAGE)
Specifications: >95%

Concentration

~1mg/ml
Specifications: 2.5mg/ml (lot specific)

Specificity

This purified product exhibits high enzymatic activity for CDNB, the synthetic substrate that is most commonly used for GST analyses. However, as is widely known for GST activity analysis using. CDNB as a substrate, low concentrations (high dilutions) of the enzyme result in lower activity values.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

~25kD

Chromosome Location

Chromosome: 22; NC_000022.10 (24376135..24384284, complement). Location: 22q11.23

OMIM

600436

3D Structure

ModBase 3D Structure for P30711

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

~30 Units/mg using spectrophotometric determination of 4- nitrobenzyl chloride conjugation with reduced glutathione (5mM) in 100mM NaPO4 (pH 6.5) at room temperature.

Product Categories/Family for GSTT1 active protein

BioSeparation; BioSep-Assay Detection; Tags

Other Notes

Small volumes of GSTT1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GSTT1. It may not necessarily be applicable to this product.

NCBI GI #

167466164

NCBI GeneID

2952

NCBI Accession #

NP_000844.2

UniProt Primary Accession #

P30711

UniProt Secondary Accession #

O00226; Q5TZY2; Q969K8; Q96IY3

UniProt Related Accession #

P30711

GenBank Nucleotide #

NM_000853.2

NCBI Official Full Name

glutathione S-transferase theta-1

NCBI Official Synonym Full Names

glutathione S-transferase theta 1

NCBI Official Symbol

GSTT1

UniProt Protein Name

Glutathione S-transferase theta-1

UniProt Synonym Protein Names

GST class-theta-1; Glutathione transferase T1-1

Protein Family

Glutathione S-transferase

UniProt Gene Name

GSTT1

UniProt Entry Name

GSTT1_HUMAN

NCBI Protein Information

glutathione S-transferase theta-1; GST class-theta-1; glutathione transferase T1-1

NCBI Summary for GSTT1

Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008]

UniProt Comments for GSTT1

GSTT1: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2- epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4- nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide. Belongs to the GST superfamily. Theta family.

Protein type: Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 2.5.1.18; Xenobiotic Metabolism - metabolism by cytochrome P450; Other Amino Acids Metabolism - glutathione

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: cytosol

Molecular Function: glutathione transferase activity; glutathione peroxidase activity

Biological Process: glutathione metabolic process; xenobiotic metabolic process

Research Articles on GSTT1

1. The NULL genotype for GSTT1 increases the risk of schizophrenia in a sample of an Iranian population.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GSTT1 active protein

Reference Product	PubMed Publications
GSTM1 active protein	>1873 publications with GSTT1 and GSTM1
GSTP1 active protein	>832 publications with GSTT1 and GSTP1
CYP1A1 active protein	>398 publications with GSTT1 and CYP1A1
GSTA1 active protein	>84 publications with GSTT1 and GSTA1
GSTA4 active protein	>6 publications with GSTT1 and GSTA4
GSTA2 active protein	>6 publications with GSTT1 and GSTA2
GSTA3 active protein	>4 publications with GSTT1 and GSTA3
ATM active protein	>2 publications with GSTT1 and ATM

Pathways associated with GSTT1 active protein

Products by Pathway	Pathway Diagram
Aflatoxin B1 Metabolism Pathway antibodies	Aflatoxin B1 Metabolism Pathway Diagram
Biological Oxidations Pathway antibodies	Biological Oxidations Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Drug Metabolism - Cytochrome P450 Pathway antibodies	Drug Metabolism - Cytochrome P450 Pathway Diagram
Drug Metabolism - Cytochrome P450 Pathway antibodies	Drug Metabolism - Cytochrome P450 Pathway Diagram
Glutathione Conjugation Pathway antibodies	Glutathione Conjugation Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram
Glutathione Metabolism Pathway antibodies	Glutathione Metabolism Pathway Diagram

Diseases associated with GSTT1 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>988 publications with GSTT1 and Neoplasms
Carcinoma Antibodies	>326 publications with GSTT1 and Carcinoma
Lung Diseases Antibodies	>207 publications with GSTT1 and Lung Diseases
Gastrointestinal Diseases Antibodies	>194 publications with GSTT1 and Gastrointestinal Diseases
Lung Neoplasms Antibodies	>136 publications with GSTT1 and Lung Neoplasms
Breast Neoplasms Antibodies	>102 publications with GSTT1 and Breast Neoplasms
Chromosome Aberrations Antibodies	>101 publications with GSTT1 and Chromosome Aberrations
Nervous System Diseases Antibodies	>97 publications with GSTT1 and Nervous System Diseases
Liver Diseases Antibodies	>95 publications with GSTT1 and Liver Diseases
Urinary Bladder Neoplasms Antibodies	>76 publications with GSTT1 and Urinary Bladder Neoplasms