MYL2 Recombinant Protein – Cat# MBS635568

Myosin Light Chain 2, Aa1-166, His-Tag (MYL2) Recombinant Protein

Name: MYL2 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS635568
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635568

Myosin, light chain 2 (MYL2) encodes the regulatory light chain associated with cardiac myosin beta heavy chain. It is an important protein involved in the regulation of myosin ATPase activity in smooth muscle and Ca+ triggers the phosphorylation of… More details

$685 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Myosin Light Chain 2, aa1-166, His-Tag (MYL2), Recombinant Protein

Full Product Name

Myosin Light Chain 2, aa1-166, His-Tag, Recombinant, Human (MYL2, MLC2, CMH10)

Product Gene Name

MYL2 recombinant protein

Product Synonym Names

Anti -Myosin Light Chain 2, aa1-166, His-Tag, Recombinant, Human (MYL2, MLC2, CMH10)

Form/Format

Supplied as a liquid in 20mM Tris pH 8.0, 20% glycerol, 5mM CaCl2.

Purity/Purification

Highly Purified
95% by SDS PAGE. Recombinant human MYL2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Preparation and Storage

For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

20.9kD

Chromosome Location

Chromosome: 12; NC_000012.11 (111348623..111358404, complement). Location: 12q24.11

OMIM

160781

3D Structure

ModBase 3D Structure for P10916

Endotoxin Level

1.0 EU/ug of protein (determined by LAL method)

Product Categories/Family for MYL2 recombinant protein

Antibodies; Abs to Myosin

Other Notes

Small volumes of MYL2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MYL2 purchase

MBS635568 is a recombinant protein targeting MYL2. Also known as Myosin Light Chain 2, aa1-166, His-Tag, Recombinant, Human (MYL2, MLC2, CMH10).

Additional Details

NCBI/Uniprot data below describe general gene information for MYL2. It may not necessarily be applicable to this product.

NCBI GI #

94981553

NCBI GeneID

4633

NCBI Accession #

NP_000423.2

UniProt Primary Accession #

P10916

UniProt Secondary Accession #

Q16123

UniProt Related Accession #

P10916

GenBank Nucleotide #

NM_000432.3

NCBI Official Full Name

myosin regulatory light chain 2, ventricular/cardiac muscle isoform

NCBI Official Synonym Full Names

myosin, light chain 2, regulatory, cardiac, slow

NCBI Official Symbol

MYL2

NCBI Official Synonym Symbols

MLC2; CMH10

UniProt Protein Name

Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Protein Family

Myosin regulatory

UniProt Gene Name

MYL2

UniProt Synonym Gene Names

MLC-2; MLC-2v

UniProt Entry Name

MLRV_HUMAN

NCBI Protein Information

myosin regulatory light chain 2, ventricular/cardiac muscle isoform; MLC-2; MLC-2v; RLC of myosin; myosin light chain 2; regulatory light chain of myosin; cardiac ventricular myosin light chain 2; slow cardiac myosin regulatory light chain 2; myosin, light polypeptide 2, regulatory, cardiac, slow

NCBI Summary for MYL2

Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008]

UniProt Comments for MYL2

MRLC2V: myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy.

Protein type: Contractile

Chromosomal Location of Human Ortholog: 12q24.11

Cellular Component: sarcomere; cytoskeleton; myofibril; cytosol; myosin complex; A band; actin cytoskeleton

Molecular Function: actin monomer binding; protein binding; structural constituent of muscle; calcium ion binding; myosin heavy chain binding

Biological Process: muscle cell fate specification; heart contraction; regulation of striated muscle contraction; ventricular cardiac muscle morphogenesis; cardiac myofibril assembly; negative regulation of cell growth; muscle fiber development; cardiac muscle contraction; muscle filament sliding; post-embryonic development

Disease: Cardiomyopathy, Familial Hypertrophic, 10

Research Articles on MYL2

1. study concludes the mutations in the last exon of MYL2 are responsible for a novel autosomal recessive lethal myosinopathy due to defects changing the C-terminal tail of the ventricular form of the myosin regulatory light chain

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with MYL2 recombinant protein

Reference Product	PubMed Publications
TNNI3 recombinant protein	>20 publications with MYL2 and TNNI3
TNNT2 recombinant protein	>19 publications with MYL2 and TNNT2
MYBPC3 recombinant protein	>18 publications with MYL2 and MYBPC3
TPM1 recombinant protein	>13 publications with MYL2 and TPM1
TTN recombinant protein	>3 publications with MYL2 and TTN

Pathways associated with MYL2 recombinant protein

Products by Pathway	Pathway Diagram
CDC42 Signaling Events Pathway antibodies	CDC42 Signaling Events Pathway Diagram
Cardiac Progenitor Differentiation Pathway antibodies	Cardiac Progenitor Differentiation Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Cardiac Muscle Contraction Pathway antibodies	Cardiac Muscle Contraction Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Dilated Cardiomyopathy Pathway antibodies	Dilated Cardiomyopathy Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram
Hypertrophic Cardiomyopathy (HCM) Pathway antibodies	Hypertrophic Cardiomyopathy (HCM) Pathway Diagram

Diseases associated with MYL2 recombinant protein

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>32 publications with MYL2 and Heart Diseases
Cardiovascular Diseases Antibodies	>32 publications with MYL2 and Cardiovascular Diseases
Cardiomyopathy, Hypertrophic Antibodies	>26 publications with MYL2 and Cardiomyopathy, Hypertrophic
Cardiomyopathy, Hypertrophic, Familial Antibodies	>11 publications with MYL2 and Cardiomyopathy, Hypertrophic, Familial
Hypertrophy Antibodies	>9 publications with MYL2 and Hypertrophy
Cardiomegaly Antibodies	>5 publications with MYL2 and Cardiomegaly
Neoplasms Antibodies	>4 publications with MYL2 and Neoplasms
Cardiomyopathy, Familial Hypertrophic, 10 Antibodies	>4 publications with MYL2 and Cardiomyopathy, Familial Hypertrophic, 10
Hypertension Antibodies	>3 publications with MYL2 and Hypertension
Fibrosis Antibodies	>1 publications with MYL2 and Fibrosis

Organs/Tissues associated with MYL2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>33 publications with MYL2 and Muscle
Heart Antibodies	>24 publications with MYL2 and Heart
Embryonic Tissue Antibodies	>3 publications with MYL2 and Embryonic Tissue
Nerve Antibodies	>2 publications with MYL2 and Nerve
Lymph Node Antibodies	>1 publications with MYL2 and Lymph Node
Vascular Antibodies	>1 publications with MYL2 and Vascular
Bone Antibodies	>1 publications with MYL2 and Bone
Mouth Antibodies	>1 publications with MYL2 and Mouth
Lung Antibodies	>1 publications with MYL2 and Lung