Glycoprotein V Active Protein

GPV (platelet glycoprotein V; designated CD42d) is an 83kD type I transmembrane (TM) glycoprotein of the leucine-rich repeat (LRR) family. It is expressed exclusively within the platelet/megakaryocyte lineage, where it noncovalently interacts with other platelet TM LRR proteins, GPIba/b and GPIX, at a rati o of one GPV to two of each other subunit. The GPI-V-IX complex tethers platelets to von Willebrand factor on the surface of injured endothelial cells. Absence of the complex results in Bernard-Soulier syndrome, a rare bleeding disorder. The human GPV cDNA encodes a 560aa protein with a 16aa signal sequence, a 507aa extracellular domain (ECD) containing 15 LRR, a 21aa TM sequence, and a short (16aa) cytoplasmic tail that binds calmodulin in resting, but not activated platelets. The human GPV ECD shares 70%, 71% and 81% aa identity with mouse, rat and equine GPV, respectively. GPV can form soluble fragments of 80kD by ADAM10 or ADAM17 cleavage after P507, or 69kD by thrombin cleavage after R476. High circulating soluble GPV may be an indicator of platelet activation, but may also be caused by high doses of aspirin. The function of GPV is not entirely clear. Deletion of GPV in mice does not produce any obvious change to surface expression or function of GPIb and GPIX, but surface expressi on of GPV requires GPIb. Deletion studies also indicate that GPV may play a minor role in collagen adhesion, and may modify platelet aggregation in response to thrombin.

Recombinant protein corresponding to aa17-523 with a C-terminal 6-His tag from human Glycoprotein V expressed in NSO cells.

Small volumes of Glycoprotein V active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS635603 is an active protein targeting Glycoprotein V. Also known as Glycoprotein V, Recombinant, Human (CD42d, GPV, Platelet glycoprotein V, GP5).