PRL-3, Aa2-173, Protein Tyrosine Phosphatase, Catalytic Domain (PTP4A3) Human Active Protein

PRL-3 Protein tyrosine kinase (PTKs) and protein tyrosine phosphatase (PTPs) play a fundamental role in regulating diverse cellular processes. One primary growth response gene, rst identi ed in regenerating liver, encodes a novel 20kD nuclear PTP known as PRL-1 (phosphatase of regenerating liver). Other than the signature sequence for PTPs, PRL-1 is not homologous to either the dual speci city PTPs (cdc25 and MKP-1) or monospeci c PTPs. Database searches using the PRL-1 sequence led to the identi cation of mouse PRL-2 and PRL-3, which exhibit 87% and 76% identity to mouse PRL-1 in their amino acid Sequence. All PRL proteins bear signi cant sequence homology to cdc14p and recently identi ed tumor suppressor PTEN/MMAC1. Northern blot analysis revealed that PRL-2 is preferentially expressed in skeletal muscle, while PRL-3 is preferentially expressed in smooth muscle, skeletal muscle and heart muscle. Both PRL-2 and PRL-3 are expressed at lower levels in other tissues. Human PRL-3 exhibits more than 95% identity to mouse PRL-3. It was identi ed in a cDNA library from an explanted human heart obtained from a patient with idiopathic cardiomyopathy It has been reported that PRL-3 plays a role in the modulation of intracellular calcium transients induced by angiotensin-II. It has also been shown that the PRL-3 gene may be related to colorectal cancer metastasis.

Catalytic domain, (a.a. 1-173), MW=19.4 kD, expressed in an E.coli expression system.

Small volumes of PTP4A3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS635630 is an active protein targeting PTP4A3. Also known as PRL-3, aa2-173, Recombinant, Human, Protein Tyrosine Phosphatase, catalytic domain (Phosphatase of regenerating liver-3). Reactive in Human. Host: Recombinant, Human from E Coli.