TAC3 Recombinant Protein – Cat# MBS635653

15% SDS-PAGE (3ug)

Neurokinin B Human (TAC3) Recombinant Protein

Name: TAC3 Recombinant Protein; Neurokinin B Human; Human; MyBioSource
Brand: MyBioSource
SKU: MBS635653
Price: 685 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635653

Neurokinin B, a member of the substance P-related tachykinin family, was previously known to be present in the same hypothalamic neurons as kisspeptin. This protein and its receptor are critical switches of regulator of human puberty, governed by the brain… More details

$685 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Neurokinin B Human (TAC3), Recombinant Protein

Full Product Name

Neurokinin B, Recombinant Human (ZNEUROK1, Neuromedin K, Tachykinin3. TAC3, NKB, NKNB)

Product Gene Name

TAC3 recombinant protein

Sequence

MGSSHHHHHH SSGLVPRGSH QSFGAVCKEP QEEVVPGGGR SKRDPDLYQL LQRLFKSHSS LEGLLKALSQ ASTDPKESTS PEKRDMHDFF VGLMGKRSVQ PDSPTDVNQE NVPSFGILKY PPRAE

Form/Format

Supplied as liquid in 20 mM Tris-HCl buffer, pH 8.0, 20% glycerol

Purity/Purification

Affinity Purified
~95% by SDS-PAGE Purified by immunoaffinity chromatography.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

13.8kD

Chromosome Location

Chromosome: 12; NC_000012.11 (57403781..57410344, complement). Location: 12q13-q21

OMIM

162330

3D Structure

ModBase 3D Structure for Q9UHF0

Product Categories/Family for TAC3 recombinant protein

Molecular Biology; MB-Peptides

Application Notes for TAC3 recombinant protein

Suitable for use in ELISA and Western Blot.

Other Notes

Small volumes of TAC3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAC3 purchase

MBS635653 is a recombinant protein targeting TAC3. Also known as Neurokinin B, Recombinant Human (ZNEUROK1, Neuromedin K, Tachykinin3. TAC3, NKB, NKNB).

Additional Details

NCBI/Uniprot data below describe general gene information for TAC3. It may not necessarily be applicable to this product.

NCBI GI #

8572053

NCBI GeneID

6866

NCBI Accession #

AAF76980.1

UniProt Primary Accession #

Q9UHF0

UniProt Secondary Accession #

Q6IAG2; Q71BC6; Q71BC9

UniProt Related Accession #

Q9UHF0

NCBI Official Full Name

neurokinin B

NCBI Official Synonym Full Names

tachykinin 3

NCBI Official Symbol

TAC3

NCBI Official Synonym Symbols

NKB; HH10; NKNB; PRO1155; ZNEUROK1

UniProt Protein Name

Tachykinin-3

UniProt Synonym Protein Names

ZNEUROK1Cleaved into the following chain:Neurokinin-B; NKB; Alternative name(s):; Neuromedin-K

Protein Family

Neurokinin

UniProt Gene Name

TAC3

UniProt Synonym Gene Names

NKNB; NKB

UniProt Entry Name

TKNK_HUMAN

NCBI Protein Information

tachykinin-3; neuromedin K; gamma tachykinin 3; preprotachykinin B; preprotachykinin-B

NCBI Summary for TAC3

This gene encodes a member of the tachykinin family of secreted neuropeptides. The encoded protein is primarily expressed in the central and peripheral nervous system and functions as a neurotransmitter. This protein is the ligand for the neurokinin-3 receptor. This protein is also expressed in the outer syncytiotrophoblast of the placenta and may be associated with pregnancy-induced hypertension and pre-eclampsia. Mutations in this gene are associated with normosmic hypogonadotropic hypogonadism. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

UniProt Comments for TAC3

TAC3: Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Belongs to the tachykinin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; receptor binding

Biological Process: tachykinin signaling pathway; neuropeptide signaling pathway; female pregnancy

Disease: Hypogonadotropic Hypogonadism 10 With Or Without Anosmia

Research Articles on TAC3

1. Rare variants in the TAC3 and TACR3 genes were identified in patients with central pubertal disorders and loss-of-function variants of TACR3 were associated with the normosmic IHH phenotype.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TAC3 recombinant protein

Reference Product	PubMed Publications
TACR3 recombinant protein	>32 publications with TAC3 and TACR3
PROKR2 recombinant protein	>13 publications with TAC3 and PROKR2
KISS1R recombinant protein	>13 publications with TAC3 and KISS1R
GNRH1 recombinant protein	>9 publications with TAC3 and GNRH1
TAC1 recombinant protein	>8 publications with TAC3 and TAC1
TACR1 recombinant protein	>3 publications with TAC3 and TACR1
TACR2 recombinant protein	>2 publications with TAC3 and TACR2

Pathways associated with TAC3 recombinant protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram
Tachykinin Receptors Bind Tachykinins Pathway antibodies	Tachykinin Receptors Bind Tachykinins Pathway Diagram

Diseases associated with TAC3 recombinant protein

Disease Name	Pubmed Publications
Hypogonadism Antibodies	>28 publications with TAC3 and Hypogonadism
Congenital Abnormalities Antibodies	>9 publications with TAC3 and Congenital Abnormalities
Olfaction Disorders Antibodies	>3 publications with TAC3 and Olfaction Disorders
Mental Disorders Antibodies	>1 publications with TAC3 and Mental Disorders
Hypersensitivity Antibodies	>1 publications with TAC3 and Hypersensitivity
Neurobehavioral Manifestations Antibodies	>1 publications with TAC3 and Neurobehavioral Manifestations

Organs/Tissues associated with TAC3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>10 publications with TAC3 and Brain
Placenta Antibodies	>2 publications with TAC3 and Placenta
Uterus Antibodies	>1 publications with TAC3 and Uterus
Connective Tissue Antibodies	>1 publications with TAC3 and Connective Tissue
Embryonic Tissue Antibodies	>1 publications with TAC3 and Embryonic Tissue