Rabbit Anti-TMIE Polyclonal Antibody – Cat# MBS6356546

TMIE Antibody – Rabbit Polyclonal

Name: TMIE Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6356546
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6356546

This gene encodes a transmembrane inner ear protein. Studies in mouse suggest that this gene is required for normal postnatal maturation of sensory hair cells in the cochlea, including correct development of stereocilia bundles. This gene is one of multiple… More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TMIE, Polyclonal Antibody

Full Product Name

TMIE, ID (TMIE, Transmembrane inner ear expressed protein) (MaxLight 750)

Product Gene Name

anti-TMIE antibody

Product Synonym Names

TMIE; Transmembrane inner ear expressed protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

17,241 Da

OMIM

600971

3D Structure

ModBase 3D Structure for Q8NEW7

Immunogen

TMIE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 78~108 amino acids from the Central region of human TMIE.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-TMIE antibody

Antibodies; Transmembrane Proteins

Applications Tested/Suitable for anti-TMIE antibody

Western Blot (WB), FLISA

Application Notes for anti-TMIE antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-TMIE antibody

Yang, J.J., et al. Int. J. Pediatr. Otorhinolaryngol. (2010). In press Sirmaci, A., et al. Clin. Genet. 75(6):562-567(2009). Santos, R.L., et al. J. Mol. Med. 84(3):226-231(2006). Cho, K.I., et al. Comp. Med. 53(6):642-648(2003). Naz, S., et al. Am. J. Hum. Genet. 71(3):632-636(2002). Mitchem, K.L., et al. Hum. Mol. Genet. 11(16):1887-1898(2002).

Other Notes

Small volumes of anti-TMIE antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TMIE purchase

MBS6356546 is an antibody targeting TMIE. Also known as TMIE, ID (TMIE, Transmembrane inner ear expressed protein) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for TMIE. It may not necessarily be applicable to this product.

NCBI GI #

158631211

NCBI GeneID

259236

NCBI Accession #

NP_671729.2

UniProt Primary Accession #

Q8NEW7

UniProt Secondary Accession #

A0AV93; A8K0R0

UniProt Related Accession #

Q8NEW7

GenBank Nucleotide #

NM_147196.2

NCBI Official Full Name

transmembrane inner ear expressed protein

NCBI Official Synonym Full Names

transmembrane inner ear

NCBI Official Symbol

TMIE

NCBI Official Synonym Symbols

DFNB6

UniProt Protein Name

Transmembrane inner ear expressed protein

Protein Family

Transmembrane inner ear expressed protein

UniProt Gene Name

TMIE

UniProt Entry Name

TMIE_HUMAN

NCBI Protein Information

transmembrane inner ear expressed protein

UniProt Comments for TMIE

TMIE: Unknown. The protein may play some role in a cellular membrane location. May reside within an internal membrane compartment and function in pathways such as those involved in protein and/or vesicle trafficking. Alternatively, the mature protein may be localized in the plasma membrane and serve as a site of interaction for other molecules through its highly charged C-terminal domain. Defects in TMIE are the cause of deafness autosomal recessive type 6 (DFNB6). DFNB6 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p21

Cellular Component: integral to membrane

Biological Process: inner ear morphogenesis; sensory perception of sound

Disease: Deafness, Autosomal Recessive 6

Research Articles on TMIE

1. Description of the spectrum of mutations in TMIE in 374 families with autosomal recessive, non-syndromic hearing loss from India.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-TMIE antibody

Reference Product	PubMed Publications
TMC1 antibody	>5 publications with TMIE and TMC1
CDH23 antibody	>4 publications with TMIE and CDH23
GJB2 antibody	>4 publications with TMIE and GJB2
TMPRSS3 antibody	>3 publications with TMIE and TMPRSS3
OTOF antibody	>3 publications with TMIE and OTOF

Diseases associated with anti-TMIE antibody

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>5 publications with TMIE and Disease Models, Animal

Organs/Tissues associated with anti-TMIE antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with TMIE and Brain
Kidney Antibodies	>1 publications with TMIE and Kidney
Eye Antibodies	>1 publications with TMIE and Eye