SFRP2 Active Protein

Name: SFRP2 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS635749
Price: 1195 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635749

Secreted Frizzled Related Proteins (sFRPs) are a family of vertebrate proteins which contain homology to the ligand-binding domain of the Frizzled family of transmembrane receptors. The sFRPs are approximately 30-35kD in size and are comprised of 3 domains: a… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SFRP2, Active Protein

Full Product Name

SFRP2, Recombinant, Mouse (Secreted Frizzled Related Protein 2, SARP-1, SDF-5) (BSA Free)

Product Gene Name

SFRP2 active protein

Host

NSO (Recombinant, Mouse)

Form/Format

Supplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with sterile PBS to 0.1mg/ml.

Purity/Purification

Highly Purified
95%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin: 1EU/ug (LAL)

Specificity

Species sequence homology: Human -98%

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~31.6kD

Chromosome Location

Chromosome: 4; NC_000004.11 (154701742..154710228, complement). Location: 4q31.3

OMIM

604157

3D Structure

ModBase 3D Structure for Q96HF1

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity

Measured by its ability to compete for the binding of rmFrizzled-1 and biotinylated rmWnt-3a. rmsFRP-2 has an IC 50 value of 0.7-3.5nM, under conditions in which rmFrizzled-1/Fc is present at 5.4nM, and biotinylated rmWnt-3a concentration is 2.7nM.

Product Categories/Family for SFRP2 active protein

Molecular Biology; MB-Wnt Proteins

Other Notes

Small volumes of SFRP2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SFRP2 purchase

MBS635749 is an active protein targeting SFRP2. Also known as SFRP2, Recombinant, Mouse (Secreted Frizzled Related Protein 2, SARP-1, SDF-5) (BSA Free). Host: NSO (Recombinant, Mouse).

Additional Details

NCBI/Uniprot data below describe general gene information for SFRP2. It may not necessarily be applicable to this product.

NCBI GI #

48475052

NCBI GeneID

6423

NCBI Accession #

NP_003004.1

UniProt Primary Accession #

Q96HF1

UniProt Secondary Accession #

O14778; Q9HAP5; B3KQR2

UniProt Related Accession #

Q96HF1

GenBank Nucleotide #

NM_003013.2

NCBI Official Full Name

secreted frizzled-related protein 2

NCBI Official Synonym Full Names

secreted frizzled-related protein 2

NCBI Official Symbol

SFRP2

NCBI Official Synonym Symbols

FRP-2; SARP1; SDF-5

UniProt Protein Name

Secreted frizzled-related protein 2

UniProt Synonym Protein Names

Secreted apoptosis-related protein 1

Protein Family

Secreted frizzled-related protein

UniProt Gene Name

SFRP2

UniProt Synonym Gene Names

FRP2; SARP1; FRP-2; sFRP-2; SARP-1

UniProt Entry Name

SFRP2_HUMAN

NCBI Protein Information

secreted frizzled-related protein 2; SARP-1; sFRP-2; secreted apoptosis related protein 1; secreted apoptosis-related protein 1

NCBI Summary for SFRP2

This gene encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. Methylation of this gene is a potential marker for the presence of colorectal cancer. [provided by RefSeq, Jul 2008]

UniProt Comments for SFRP2

SFRP2: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Belongs to the secreted frizzled-related protein (sFRP) family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q31.3

Cellular Component: extracellular matrix; extracellular space; integral to membrane

Molecular Function: integrin binding; G-protein coupled receptor activity; Wnt-protein binding; Wnt receptor activity; fibronectin binding; receptor agonist activity

Biological Process: convergent extension involved in axis elongation; collagen fibril organization; negative regulation of Wnt receptor signaling pathway; positive regulation of apoptosis; negative regulation of caspase activity; negative regulation of BMP signaling pathway; negative regulation of cell proliferation; negative regulation of mesodermal cell fate specification; cell-cell signaling; positive regulation of cell proliferation; negative regulation of cell migration; response to nutrient; negative regulation of epithelial cell proliferation; response to drug; negative regulation of peptidyl-tyrosine phosphorylation; negative regulation of JNK activity; male gonad development; positive regulation of cell adhesion mediated by integrin; digestive tract morphogenesis; chondrocyte development; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; patterning of blood vessels; positive regulation of osteoblast differentiation; positive regulation of angiogenesis; neural tube closure; cellular response to extracellular stimulus; positive regulation of fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; embryonic digit morphogenesis; negative regulation of cell growth; negative regulation of transcription, DNA-dependent

Research Articles on SFRP2

1. Concomitant epigenetic silencing of SOX1 and SFRPs through promoter hypermethylation is frequent in hepatocellular carcinoma, and this might contribute to abnormal activation of canonical Wnt signal pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SFRP2 active protein

Reference Product	PubMed Publications
WNT3A active protein	>16 publications with SFRP2 and WNT3A
WNT4 active protein	>12 publications with SFRP2 and WNT4
SHH active protein	>7 publications with SFRP2 and SHH
WNT11 active protein	>7 publications with SFRP2 and WNT11
WNT1 active protein	>7 publications with SFRP2 and WNT1
WNT10B active protein	>6 publications with SFRP2 and WNT10B
WNT9A active protein	>5 publications with SFRP2 and WNT9A
WNT7B active protein	>4 publications with SFRP2 and WNT7B
WNT2B active protein	>3 publications with SFRP2 and WNT2B
WNT6 active protein	>3 publications with SFRP2 and WNT6

Pathways associated with SFRP2 active protein

Products by Pathway	Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram
Wnt Signaling Pathway antibodies	Wnt Signaling Pathway Diagram

Diseases associated with SFRP2 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>125 publications with SFRP2 and Neoplasms
Carcinoma Antibodies	>50 publications with SFRP2 and Carcinoma
Colorectal Neoplasms Antibodies	>30 publications with SFRP2 and Colorectal Neoplasms
Adenocarcinoma Antibodies	>20 publications with SFRP2 and Adenocarcinoma
Breast Neoplasms Antibodies	>14 publications with SFRP2 and Breast Neoplasms
Fibrosis Antibodies	>12 publications with SFRP2 and Fibrosis
Carcinoma, Squamous Cell Antibodies	>11 publications with SFRP2 and Carcinoma, Squamous Cell
Cell Transformation, Neoplastic Antibodies	>9 publications with SFRP2 and Cell Transformation, Neoplastic
Liver Diseases Antibodies	>7 publications with SFRP2 and Liver Diseases
Liver Neoplasms Antibodies	>7 publications with SFRP2 and Liver Neoplasms

Organs/Tissues associated with SFRP2 active protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>53 publications with SFRP2 and Eye
Bone Antibodies	>47 publications with SFRP2 and Bone
Muscle Antibodies	>32 publications with SFRP2 and Muscle
Embryonic Tissue Antibodies	>28 publications with SFRP2 and Embryonic Tissue
Connective Tissue Antibodies	>18 publications with SFRP2 and Connective Tissue
Brain Antibodies	>13 publications with SFRP2 and Brain
Intestine Antibodies	>12 publications with SFRP2 and Intestine
Kidney Antibodies	>12 publications with SFRP2 and Kidney
Heart Antibodies	>11 publications with SFRP2 and Heart
Nerve Antibodies	>10 publications with SFRP2 and Nerve