• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Furin Mouse (FURIN) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635814

Furin is a member of the proprotein convertase (PC) family, which belongs to the subtilisin superfamily of serine proteases. As a cellular protease, Furin processes a variety of proproteins in secretory pathway compartments by cleaving after… More details

$1110 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Furin Mouse, Active Protein
Full Product Name
Furin, Recombinant Mouse
Product Gene Name
Furin active protein
Form/Format
Supplied as a liquid in Tris, Calcium Chloride2, sodium chloride, Brij-35, Glycerol.
Purity/Purification
Highly Purified
~95% (SDS-PAGE)
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
~77kD
Chromosome Location
Chromosome: 7; NC_000073.6 (80389194..80405431, complement). Location: 7 D1-E2; 7 45.65 cM
3D Structure
ModBase 3D Structure for P23188
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC, The specific activity is >150 pmoles/min/ug, as measured under the described conditions.
Endotoxin Level
<1EU/ug (LAL method)

Product Categories/Family for Furin active protein

Molecular Biology; MB-Enzymes

Other Notes

Small volumes of Furin active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Furin purchase

MBS635814 is an active protein targeting Furin. Also known as Furin, Recombinant Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for Furin. It may not necessarily be applicable to this product.

NCBI GI #
125347022
NCBI GeneID
18550
NCBI Accession #
NP_001074923.1
UniProt Primary Accession #
P23188
UniProt Secondary Accession #
Q6GTN6
UniProt Related Accession #
P23188
GenBank Nucleotide #
NM_001081454.1
NCBI Official Full Name
furin preproprotein
NCBI Official Synonym Full Names
furin (paired basic amino acid cleaving enzyme)
NCBI Official Symbol
Furin
NCBI Official Synonym Symbols
Fur; PACE; SPC1; Pcsk3; 9130404I01Rik
UniProt Protein Name
Furin
UniProt Synonym Protein Names
Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACE; Prohormone convertase 3
Protein Family
Furin
UniProt Gene Name
Furin
UniProt Synonym Gene Names
Fur; Pcsk3; PACE
UniProt Entry Name
FURIN_MOUSE
NCBI Protein Information
furin; prohormone convertase 3; dibasic-processing enzyme; subtilisin pro-protein processing enzyme; proprotein convertase subtilisin/kexin type 3; paired basic amino acid residue cleaving enzyme; paired basic amino acid residue-cleaving enzyme

NCBI Summary for Furin

This gene encodes a calcium-dependent serine endoprotease that proteolytically activates different proprotein substrates traversing the secretory pathway. The encoded protein undergoes proteolytic autoactivation during which an N-terminal propeptide is cleaved to generate the mature protein. Mice lacking the encoded protein die at an embryonic stage and display hemodynamic insufficiency, cardiac ventral closure defect, axial rotation defect and abnormal yolk sac vasculature. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
Show more

UniProt Comments for Furin

FURIN: Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif. Belongs to the peptidase S8 family. Furin subfamily.

Protein type: Membrane protein, integral; Cell surface; Vesicle; Protease; EC 3.4.21.75

Cellular Component: Golgi apparatus; extracellular space; endoplasmic reticulum membrane; Golgi cisterna; cell surface; early endosome; integral to membrane; trans-Golgi network; lipid raft; trans-Golgi network transport vesicle membrane; trans-Golgi network transport vesicle; membrane; plasma membrane

Molecular Function: serine-type endopeptidase inhibitor activity; peptidase activity; protein binding; protease binding; hydrolase activity; serine-type peptidase activity; metal ion binding; serine-type endopeptidase activity; endopeptidase activity; nerve growth factor binding; peptide binding

Biological Process: signal peptide processing; peptide hormone processing; positive regulation of transforming growth factor beta receptor signaling pathway; regulation of signal transduction; proteolysis; peptide biosynthetic process; nerve growth factor production; negative regulation of transforming growth factor-beta1 production; cell proliferation; regulation of low-density lipoprotein receptor biosynthetic process; regulation of endopeptidase activity; regulation of protein catabolic process; protein processing; negative regulation of low-density lipoprotein receptor catabolic process; secretion by cell; positive regulation of cell migration
Show more

Research Articles on Furin

1. overexpression of PCs, furin and PC5, but not PC7, which are all expressed in SMC, increase PKGI cleavage in a dose-dependent manner

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Furin active protein

 Reference Product  PubMed Publications
 Tgfb1 active protein  >40 publications with Furin and Tgfb1
 Ngf active protein  >26 publications with Furin and Ngf
 Pcsk9 active protein  >22 publications with Furin and Pcsk9
 Notch1 active protein  >17 publications with Furin and Notch1
 Mmp14 active protein  >10 publications with Furin and Mmp14
 Mmp11 active protein  >4 publications with Furin and Mmp11
 Mbtps1 active protein  >2 publications with Furin and Mbtps1
 Timp2 active protein  >1 publications with Furin and Timp2

Pathways associated with Furin active protein

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Degradation Of Collagen Pathway antibodies  Degradation Of Collagen Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway antibodies  Gamma-carboxylation, Transport, And Amino-terminal Cleavage Of Proteins Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram

Diseases associated with Furin active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >210 publications with Furin and Neoplasms
 Carcinoma Antibodies  >80 publications with Furin and Carcinoma
 Necrosis Antibodies  >77 publications with Furin and Necrosis
 Immune System Diseases Antibodies  >59 publications with Furin and Immune System Diseases
 Inflammation Antibodies  >46 publications with Furin and Inflammation
 Lung Diseases Antibodies  >27 publications with Furin and Lung Diseases
 Kidney Diseases Antibodies  >25 publications with Furin and Kidney Diseases
 Breast Neoplasms Antibodies  >24 publications with Furin and Breast Neoplasms
 Adenocarcinoma Antibodies  >23 publications with Furin and Adenocarcinoma
 Edema Antibodies  >22 publications with Furin and Edema

Organs/Tissues associated with Furin active protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >243 publications with Furin and Blood
 Brain Antibodies  >201 publications with Furin and Brain
 Kidney Antibodies  >123 publications with Furin and Kidney
 Liver Antibodies  >120 publications with Furin and Liver
 Bone Antibodies  >91 publications with Furin and Bone
 Muscle Antibodies  >86 publications with Furin and Muscle
 Ovary Antibodies  >72 publications with Furin and Ovary
 Lung Antibodies  >72 publications with Furin and Lung
 Embryonic Tissue Antibodies  >52 publications with Furin and Embryonic Tissue
 Heart Antibodies  >48 publications with Furin and Heart
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000