LOXL3 Active Protein

Name: LOXL3 Active Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS635878
Price: 1005 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS635878

Lysyl oxidase-like protein 3 (LOXL3) is a secreted copper amine oxidase. The N-terminal region of LOXL3 contains four scavenger receptor cysteine- rich (SRCR) domains. The C-terminal region consists of a catalytic domain similar to other lysyl oxidases and a… More details

$1005 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LOXL3, Active Protein

Full Product Name

LOXL3, Recombinant, Human (Lysyl Oxidase Homolog 3, Lysyl Oxidase-like Protein 3, LOXL)

Product Gene Name

LOXL3 active protein

Form/Format

Supplied as a liquid in MES, sodium chloride.

Purity/Purification

Highly Purified
~90% (SDS-PAGE, reducing conditions)

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

82kD

Chromosome Location

Chromosome: 2; NC_000002.11 (74759946..74781088, complement). Location: 2p13

OMIM

607163

3D Structure

ModBase 3D Structure for P58215

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity

Measured by its ability to produce to produce hydrogen peroxide during the oxidation of benzylamine.

Specific Activity

1.5pmoles/min/ug

Endotoxin Level

1EU/1ug (LAL)

Product Categories/Family for LOXL3 active protein

Molecular Biology; MB-Enzymes; Oxidase

Application Notes for LOXL3 active protein

SDS-PAGE: 90-100kD, reducing conditions

Other Notes

Small volumes of LOXL3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LOXL3 purchase

MBS635878 is an active protein targeting LOXL3. Also known as LOXL3, Recombinant, Human (Lysyl Oxidase Homolog 3, Lysyl Oxidase-like Protein 3, LOXL).

Additional Details

NCBI/Uniprot data below describe general gene information for LOXL3. It may not necessarily be applicable to this product.

NCBI GI #

14211943

NCBI GeneID

84695

NCBI Accession #

NP_115992.1

UniProt Primary Accession #

P58215

UniProt Secondary Accession #

Q96RS1; D6W5J1

UniProt Related Accession #

P58215

GenBank Nucleotide #

NM_032603.2

NCBI Official Full Name

lysyl oxidase homolog 3

NCBI Official Synonym Full Names

lysyl oxidase-like 3

NCBI Official Symbol

LOXL3

NCBI Official Synonym Symbols

LOXL

UniProt Protein Name

Lysyl oxidase homolog 3

UniProt Synonym Protein Names

Lysyl oxidase-like protein 3

Protein Family

Lysyl oxidase

UniProt Gene Name

LOXL3

UniProt Synonym Gene Names

LOXL

UniProt Entry Name

LOXL3_HUMAN

NCBI Protein Information

lysyl oxidase homolog 3; lysyl oxidase-like protein 3

NCBI Summary for LOXL3

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for LOXL3

LOXL3: a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

Protein type: Secreted, signal peptide; Secreted; EC 1.4.3.-; Oxidoreductase

Chromosomal Location of Human Ortholog: 2p13

Cellular Component: extracellular space; membrane; cytoplasm; extracellular region; nucleus

Molecular Function: protein binding; copper ion binding; protein-lysine 6-oxidase activity; scavenger receptor activity

Biological Process: receptor-mediated endocytosis; epithelial to mesenchymal transition; negative regulation of transcription, DNA-dependent

Research Articles on LOXL3

1. TGF-beta1 induced injured MCL to express more LOXs than injured ACL (up to 1.85-fold in LOX, 2.21-fold in LOXL-1, 1.71-fold in LOXL-2, 2.52-fold in LOXL-3 and 3.32-fold in LOXL-4).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LOXL3 active protein

Reference Product	PubMed Publications
HTRA2 active protein	>1 publications with LOXL3 and HTRA2

Pathways associated with LOXL3 active protein

Products by Pathway	Pathway Diagram
Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies	Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
Collagen Formation Pathway antibodies	Collagen Formation Pathway Diagram
Crosslinking Of Collagen Fibrils Pathway antibodies	Crosslinking Of Collagen Fibrils Pathway Diagram
Elastic Fibre Formation Pathway antibodies	Elastic Fibre Formation Pathway Diagram
Extracellular Matrix Organization Pathway antibodies	Extracellular Matrix Organization Pathway Diagram

Diseases associated with LOXL3 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>7 publications with LOXL3 and Neoplasms
Fibrosis Antibodies	>4 publications with LOXL3 and Fibrosis
Hypertension Antibodies	>2 publications with LOXL3 and Hypertension
Adenocarcinoma Antibodies	>2 publications with LOXL3 and Adenocarcinoma
Inflammation Antibodies	>1 publications with LOXL3 and Inflammation
Nervous System Diseases Antibodies	>1 publications with LOXL3 and Nervous System Diseases
Uterine Neoplasms Antibodies	>1 publications with LOXL3 and Uterine Neoplasms

Organs/Tissues associated with LOXL3 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>5 publications with LOXL3 and Blood
Testis Antibodies	>4 publications with LOXL3 and Testis
Eye Antibodies	>3 publications with LOXL3 and Eye
Connective Tissue Antibodies	>2 publications with LOXL3 and Connective Tissue
Brain Antibodies	>2 publications with LOXL3 and Brain
Skin Antibodies	>2 publications with LOXL3 and Skin
Pancreas Antibodies	>2 publications with LOXL3 and Pancreas
Bone Antibodies	>2 publications with LOXL3 and Bone
Prostate Antibodies	>1 publications with LOXL3 and Prostate
Uterus Antibodies	>1 publications with LOXL3 and Uterus