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Follicle Stimulating Hormone (FSHB) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636013

Recombinant Human FSH is a glycoprotein having a total molecular mass of 30kD. Follicle Stimulating Hormone is a heterodimeric hormone consisting of 92 amino acid alpha chain and 111 amino acid beta chain. More details

$980 / 0.002 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Follicle Stimulating Hormone (FSHB), Active Protein
Full Product Name
Follicle Stimulating Hormone, Recombinant, Human (FSH)
Product Gene Name
FSHB active protein
Host
CHO cells
Form/Format
Supplied as a lyophilized powder from sucrose, dibasic sodium phosphate, monobasic sodium phosphate. Reconstitute in sterile ddH2O, 0.1% HSA or BSA to 0.1mg/ml, which can then be further diluted to other aqueous solutions
Purity/Purification
Highly Purified
95% by RP-HPLC, FPLC, or reducing/non-reducing SDS-PAGE Silver Stain. Chromatographically purified.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile ddH2O, 0.1% HSA or BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
30kD
Chromosome Location
Chromosome: 11; NC_000011.9 (30252563..30256824). Location: 11p13
OMIM
136530
3D Structure
ModBase 3D Structure for P01225
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Recombinant FSH is biologically active compared to standard (IRP reference preparation 70/45). The activity is 13,636IU/mg.

Product Categories/Family for FSHB active protein

Molecular Biology; MB-Hormones; Steroids

Other Notes

Small volumes of FSHB active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FSHB purchase

MBS636013 is an active protein targeting FSHB. Also known as Follicle Stimulating Hormone, Recombinant, Human (FSH). Host: CHO cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FSHB. It may not necessarily be applicable to this product.

NCBI GI #
182762
NCBI GeneID
2488
NCBI Accession #
AAA52476.1
UniProt Primary Accession #
P01225
UniProt Secondary Accession #
Q14D61; A2TF08; A5JVV3
UniProt Related Accession #
P01225
NCBI Official Full Name
follicle-stimulating hormone
NCBI Official Synonym Full Names
follicle stimulating hormone, beta polypeptide
NCBI Official Symbol
FSHB
UniProt Protein Name
Follitropin subunit beta
UniProt Synonym Protein Names
Follicle-stimulating hormone beta subunit; FSH-B; FSH-beta; Follitropin beta chain
Protein Family
Follitropin
UniProt Gene Name
FSHB
UniProt Synonym Gene Names
FSH-B; FSH-beta
UniProt Entry Name
FSHB_HUMAN
NCBI Protein Information
follitropin subunit beta; FSH-B; FSH-beta; follitropin beta chain; follitropin, beta chain; follicle-stimulating hormone beta subunit

NCBI Summary for FSHB

The pituitary glycoprotein hormone family includes follicle-stimulating hormone, luteinizing hormone, chorionic gonadotropin, and thyroid-stimulating hormone. All of these glycoproteins consist of an identical alpha subunit and a hormone-specific beta subunit. This gene encodes the beta subunit of follicle-stimulating hormone. In conjunction with luteinizing hormone, follicle-stimulating hormone induces egg and sperm production. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for FSHB

FSHB: Stimulates development of follicle and spermatogenesis in the reproductive organs. Defects in FSHB are a cause of isolated follicle- stimulating hormone deficiency (IFSHD). Selective follicle-stimulating hormone deficiency is an uncommon cause of infertility, producing amenorrhea and hypogonadism in women and oligo or azoospermia with normal testosterone levels in normally virilised men. Belongs to the glycoprotein hormones subunit beta family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: cytoplasm; extracellular region

Molecular Function: follicle-stimulating hormone activity; protein binding; hormone activity

Biological Process: progesterone biosynthetic process; follicle-stimulating hormone signaling pathway; peptide hormone processing; female gamete generation; Sertoli cell proliferation; female pregnancy; signal transduction; cellular protein metabolic process; regulation of osteoclast differentiation; transforming growth factor beta receptor signaling pathway; positive regulation of cell proliferation; positive regulation of bone resorption; positive regulation of transcription from RNA polymerase II promoter; positive regulation of cell migration

Disease: Follicle-stimulating Hormone Deficiency, Isolated
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Research Articles on FSHB

1. activin-regulated transcription mediated by forkhead box L2 [review]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FSHB active protein

 Reference Product  PubMed Publications
 CGA active protein  >26 publications with FSHB and CGA
 FSHR active protein  >19 publications with FSHB and FSHR
 GNRHR active protein  >14 publications with FSHB and GNRHR
 GNRH1 active protein  >6 publications with FSHB and GNRH1
 BMP2 active protein  >4 publications with FSHB and BMP2
 INHA active protein  >3 publications with FSHB and INHA
 INHBB active protein  >2 publications with FSHB and INHBB
 INHBA active protein  >1 publications with FSHB and INHBA

Pathways associated with FSHB active protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 FSH Signaling Pathway antibodies  FSH Signaling Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 GnRH Signaling Pathway antibodies  GnRH Signaling Pathway Diagram
 Hormone Ligand-binding Receptors Pathway antibodies  Hormone Ligand-binding Receptors Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram

Diseases associated with FSHB active protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >15 publications with FSHB and Neoplasms
 Infertility, Male Antibodies  >10 publications with FSHB and Infertility, Male
 Kidney Diseases Antibodies  >9 publications with FSHB and Kidney Diseases
 Infertility, Female Antibodies  >7 publications with FSHB and Infertility, Female
 Nervous System Diseases Antibodies  >4 publications with FSHB and Nervous System Diseases
 Disorders of Sex Development Antibodies  >3 publications with FSHB and Disorders of Sex Development
 Hyperplasia Antibodies  >1 publications with FSHB and Hyperplasia
 Breast Neoplasms Antibodies  >1 publications with FSHB and Breast Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with FSHB and Prenatal Exposure Delayed Effects
 Hypogonadism Antibodies  >1 publications with FSHB and Hypogonadism

Organs/Tissues associated with FSHB active protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >61 publications with FSHB and Brain
 Pituitary Gland Antibodies  >56 publications with FSHB and Pituitary Gland
 Testis Antibodies  >19 publications with FSHB and Testis
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