PON2 Recombinant Protein – Cat# MBS636103

Paraoxonase 2 (PON2) Recombinant Protein

Name: PON2 Recombinant Protein; Paraoxonase 2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS636103
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636103

Paraoxonase 2 (PON2) is a member of a multigene family whose genes share 65% identity at the amino acid level, and is expressed in a variety of tissues, including the pancreas. PON2 overexpression has been shown to lower the intracellular oxidative state and… More details

$755 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Paraoxonase 2 (PON2), Recombinant Protein

Full Product Name

Paraoxonase 2, Recombinant, Human (PON2, Serum paraoxonase arylesterase 2, A-esterase 2, Aromatic esterase 2)

Product Gene Name

PON2 recombinant protein

Sequence

MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA GSEDID ILPNGLAFFS VGLKFPGLHS FAPDKPGGIL MMDLKEEKPR ARELRISRGF DLASFNP HGISTFIDND DTVYLFVVNH PEFKNTVEIF KFEEAENSLL HLKTVKHELL PSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH WANVVYYSPN EVKVVAEGFD SAN GINISPDDKY IYVADILAHE IHVLEKHTNM NLTQLKVLEL DTLVDNLSID PSSGDIW VGCHPNGQKL FVYDPNNPPS SEVLRIQNIL SEKPTVTTVY ANNGSVLQGS SVASVY DGKLLIGTLY HRALYCELZ.

Host

E Coli

Form/Format

Supplied as a liquid in PBS, 50% glycerol.

Purity/Purification

Highly Purified
~95% (SDS-PAGE). Single band on Western Blot.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

43.5kD

Chromosome Location

Chromosome: 7; NC_000007.13 (95034174..95064636, complement). Location: 7q21.3

OMIM

602447

3D Structure

ModBase 3D Structure for Q15165

Product Categories/Family for PON2 recombinant protein

Molecular Biology; MB-Enzymes

Application Notes for PON2 recombinant protein

Suitable for use as a positive control in Western Blot, ELISA, Immunoprecipitation and other immunological experiments. Other applications not tested

Other Notes

Small volumes of PON2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PON2 purchase

MBS636103 is a recombinant protein targeting PON2. Also known as Paraoxonase 2, Recombinant, Human (PON2, Serum paraoxonase arylesterase 2, A-esterase 2, Aromatic esterase 2). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for PON2. It may not necessarily be applicable to this product.

NCBI GI #

1333632

NCBI GeneID

5445

NCBI Accession #

AAC41995.1

UniProt Primary Accession #

Q15165

UniProt Secondary Accession #

O15114; O15115; O75856; Q5FBX7; Q86YL0; A4D1H7; B2RCP9; B4DJD5

UniProt Related Accession #

Q15165

NCBI Official Full Name

paraoxonase 2

NCBI Official Synonym Full Names

paraoxonase 2

NCBI Official Symbol

PON2

UniProt Protein Name

Serum paraoxonase/arylesterase 2

UniProt Synonym Protein Names

Aromatic esterase 2; A-esterase 2; Serum aryldialkylphosphatase 2

Protein Family

Serum paraoxonase/arylesterase

UniProt Gene Name

PON2

UniProt Synonym Gene Names

PON 2

UniProt Entry Name

PON2_HUMAN

NCBI Protein Information

serum paraoxonase/arylesterase 2; PON 2; A-esterase 2; paraoxonase nirs; aromatic esterase 2; serum aryldialkylphosphatase 2

NCBI Summary for PON2

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

UniProt Comments for PON2

PON2: Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. Belongs to the paraoxonase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.1.2; EC 3.1.1.81; Motility/polarity/chemotaxis; Hydrolase

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: mitochondrion; lysosome; extracellular region; plasma membrane; nucleus

Molecular Function: identical protein binding; arylesterase activity; metal ion binding

Biological Process: response to oxidative stress; aromatic compound catabolic process

Research Articles on PON2

1. In the presence of metabolic syndrome and diabetes, PON2-311CC was associated with an increased risk of significant coronary stenosis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with PON2 recombinant protein

Reference Product	PubMed Publications
APOE recombinant protein	>16 publications with PON2 and APOE
APOA1 recombinant protein	>1 publications with PON2 and APOA1

Pathways associated with PON2 recombinant protein

Products by Pathway	Pathway Diagram
Phase I, Non P450 Pathway antibodies	Phase I, Non P450 Pathway Diagram

Diseases associated with PON2 recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>102 publications with PON2 and Cardiovascular Diseases
Atherosclerosis Antibodies	>72 publications with PON2 and Atherosclerosis
Nervous System Diseases Antibodies	>39 publications with PON2 and Nervous System Diseases
Heart Diseases Antibodies	>33 publications with PON2 and Heart Diseases
Brain Diseases Antibodies	>28 publications with PON2 and Brain Diseases
Inflammation Antibodies	>11 publications with PON2 and Inflammation
Kidney Diseases Antibodies	>10 publications with PON2 and Kidney Diseases
Hypertension Antibodies	>9 publications with PON2 and Hypertension
Myocardial Infarction Antibodies	>6 publications with PON2 and Myocardial Infarction
Liver Diseases Antibodies	>5 publications with PON2 and Liver Diseases

Organs/Tissues associated with PON2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>80 publications with PON2 and Blood
Liver Antibodies	>33 publications with PON2 and Liver
Heart Antibodies	>28 publications with PON2 and Heart
Vascular Antibodies	>23 publications with PON2 and Vascular
Brain Antibodies	>18 publications with PON2 and Brain
Kidney Antibodies	>11 publications with PON2 and Kidney
Lung Antibodies	>10 publications with PON2 and Lung
Intestine Antibodies	>8 publications with PON2 and Intestine
Muscle Antibodies	>7 publications with PON2 and Muscle
Nerve Antibodies	>6 publications with PON2 and Nerve