EIF4E Recombinant Protein – Cat# MBS636128

Eukaryotic Translation Initiation Factor 4e (EIF4E) Recombinant Protein

Name: EIF4E Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS636128
Price: 1155 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636128

Eukaryotic initiation factor 4E (eIF4E) binds to the mRNA cap structure, thereby mediating the initiation of translation. eIF4E interacts with eIF4G, which serves as a scaffold protein for the assembly of eIF4E and eIF4A to form the eIF4F complex. Upon… More details

$1155 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Eukaryotic Translation Initiation Factor 4E (Eif4e), Recombinant Protein

Full Product Name

Eukaryotic Translation Initiation Factor 4E, Recombinant, Human (eIF4E, eIF4EL1)

Product Gene Name

Eif4e recombinant protein

Form/Format

Supplied as a liquid in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 50% glycerol.

Purity/Purification

Purified
0.7

Preparation and Storage

Aliquot to avoid repeated freezing and thawing and store at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.

Molecular Weight

51kD

Chromosome Location

Chromosome: 2; NC_005101.3 (262355381..262387512). Location: 2q44

3D Structure

ModBase 3D Structure for P63074

Product Categories/Family for Eif4e recombinant protein

Molecular Biology; MB-Translation Initiation Factors

Application Notes for Eif4e recombinant protein

Suitable for use as a substrate for MNK1 kinase.

Other Notes

Small volumes of Eif4e recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Eif4e purchase

MBS636128 is a recombinant protein targeting Eif4e. Also known as Eukaryotic Translation Initiation Factor 4E, Recombinant, Human (eIF4E, eIF4EL1).

Additional Details

NCBI/Uniprot data below describe general gene information for Eif4e. It may not necessarily be applicable to this product.

NCBI GI #

16758870

NCBI GeneID

117045

NCBI Accession #

NP_446426.1

UniProt Primary Accession #

P63074

UniProt Secondary Accession #

P20415

UniProt Related Accession #

P63074

GenBank Nucleotide #

NM_053974.2

NCBI Official Full Name

eukaryotic translation initiation factor 4E

NCBI Official Synonym Full Names

eukaryotic translation initiation factor 4E

NCBI Official Symbol

Eif4e

UniProt Protein Name

Eukaryotic translation initiation factor 4E

UniProt Synonym Protein Names

eIF-4F 25 kDa subunit; mRNA cap-binding protein

Protein Family

Eukaryotic translation initiation factor

UniProt Gene Name

Eif4e

UniProt Synonym Gene Names

eIF-4E; eIF4E

UniProt Entry Name

IF4E_RAT

NCBI Protein Information

eukaryotic translation initiation factor 4E; eIF-4E; eIF-4F 25 kDa subunit; mRNA cap-binding protein

NCBI Summary for Eif4e

binds to the mRNA 7-methylguanosine cap and mediates mRNA binding to the 40S ribosome in the rate limiting step in translational initiation [RGD, Feb 2006]

UniProt Comments for Eif4e

EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex.

Protein type: Translation initiation; Translation

Cellular Component: mRNA cap complex; protein complex; stress granule; eukaryotic translation initiation factor 4F complex; cytoplasm

Molecular Function: protein binding; eukaryotic initiation factor 4G binding; translation initiation factor activity

Biological Process: regulation of translation; behavioral fear response; translation; translational initiation; positive regulation of mitotic cell cycle; lung development; G1/S transition of mitotic cell cycle

Research Articles on Eif4e

1. At birth increased Po(2) acts with glucocorticosteroid through an mTOR-related pathway to increase alpha-ENaC protein synthesis, thereby promoting lung fluid absorption.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with Eif4e recombinant protein

Products by Pathway	Pathway Diagram
Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies	Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
Alpha6-Beta4 Integrin Signaling Pathway antibodies	Alpha6-Beta4 Integrin Signaling Pathway Diagram
Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies	Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
Cap-dependent Translation Initiation Pathway antibodies	Cap-dependent Translation Initiation Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Deadenylation Of MRNA Pathway antibodies	Deadenylation Of MRNA Pathway Diagram
Deadenylation-dependent MRNA Decay Pathway antibodies	Deadenylation-dependent MRNA Decay Pathway Diagram
Eukaryotic Translation Initiation Pathway antibodies	Eukaryotic Translation Initiation Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
HIF-1 Signaling Pathway antibodies	HIF-1 Signaling Pathway Diagram

Diseases associated with Eif4e recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>561 publications with Eif4e and Neoplasms
Carcinoma Antibodies	>193 publications with Eif4e and Carcinoma
Cell Transformation, Neoplastic Antibodies	>104 publications with Eif4e and Cell Transformation, Neoplastic
Adenocarcinoma Antibodies	>74 publications with Eif4e and Adenocarcinoma
Nervous System Diseases Antibodies	>65 publications with Eif4e and Nervous System Diseases
Hypertrophy Antibodies	>55 publications with Eif4e and Hypertrophy
Necrosis Antibodies	>52 publications with Eif4e and Necrosis
Neoplasms, Experimental Antibodies	>47 publications with Eif4e and Neoplasms, Experimental
Cardiovascular Diseases Antibodies	>45 publications with Eif4e and Cardiovascular Diseases
Lung Neoplasms Antibodies	>44 publications with Eif4e and Lung Neoplasms

Organs/Tissues associated with Eif4e recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>129 publications with Eif4e and Liver
Brain Antibodies	>123 publications with Eif4e and Brain
Heart Antibodies	>88 publications with Eif4e and Heart
Lung Antibodies	>77 publications with Eif4e and Lung
Kidney Antibodies	>70 publications with Eif4e and Kidney
Pancreas Antibodies	>39 publications with Eif4e and Pancreas
Ovary Antibodies	>36 publications with Eif4e and Ovary
Prostate Antibodies	>30 publications with Eif4e and Prostate
Embryonic Tissue Antibodies	>24 publications with Eif4e and Embryonic Tissue
Adipose Tissue Antibodies	>16 publications with Eif4e and Adipose Tissue