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Speckle-Type POZ Protein (SPOP) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636185

MBS636185 is a recombinant protein targeting SPOP. Also known as Speckle-type POZ Protein (SPOP) Recombinant, Human. Host: E Coli. More details

$580 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Speckle-type POZ Protein (SPOP), Recombinant Protein
Full Product Name
Speckle-type POZ Protein (SPOP) Recombinant, Human
Product Gene Name
Host
E Coli
Form/Format
Supplied as a liquid in 10mM Tris, pH 8, 0.1% Triton X-100, 0.002% sodium azide.
Purity/Purification
Highly Purified
Highly purified
Preparation and Storage
Aliquot to avoid repeated freezing and thawing and store at -70 degree C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
42,132 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (47676246..47755525, complement). Location: 17q21.33
OMIM
602650
3D Structure
ModBase 3D Structure for O43791
Quality Control
SDS-PAGE
Applications Tested/Suitable for SPOP recombinant protein
ELISA (EL/EIA)
Application Notes for SPOP recombinant protein
Suitable for use in ELISA and Western Blot.

SDS-Page of SPOP recombinant protein

SDS: Analysis of S5373. 4-20% SDS gradient gel. Coomassie blue staining.
SPOP Recombinant Protein – Cat# MBS636185

Other Notes

Small volumes of SPOP recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPOP. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
speckle-type POZ protein
NCBI Official Synonym Full Names
speckle-type POZ protein
NCBI Official Symbol
SPOP
NCBI Official Synonym Symbols
TEF2; BTBD32
UniProt Protein Name
Speckle-type POZ protein
UniProt Synonym Protein Names
HIB homolog 1; Roadkill homolog 1
UniProt Gene Name
SPOP
UniProt Entry Name
SPOP_HUMAN
NCBI Protein Information
speckle-type POZ protein; HIB homolog 1; roadkill homolog 1

NCBI Summary for SPOP

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
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UniProt Comments for SPOP

SPOP: Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex. In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3. Belongs to the Tdpoz family.

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: nucleoplasm; nuclear speck; nucleus

Molecular Function: protein binding; ubiquitin protein ligase binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination during ubiquitin-dependent protein catabolic process; glucose homeostasis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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