Ikb Alpha, Activated, 6-His-Tag Human Recombinant Protein

Ikba is a cellular protein that inhibits the transcription factor NF-kB. NF-kB plays a central role in cellular stress and inflammatory responses by controlling cytokine-inducible gene expression and lymphocyte stimulation by antigens. In non-stimulated cells NF-kB is sequestered in the cytoplasm via the inhibitory protein Ikba, which obscures the nuclear localization signal of NF-kB and also blocks its ability to bind DNA. In response to various stimuli, including viral infection, ultraviolet radiation and inflammatory cytokines, Ikba is phosphorylated by the protein kinase complex IKK, which triggers its rapid degradation by ubiquitin mediated proteolysis. The liberated NF-kB then translocates to the nucleus and activates the expression of target genes. Mutations in the gene for Ikba result in the functional impairment of NF-kB which causes a decreased production of proinflammatory cytokines and certain interferons, rendering patients susceptible to infection.

Small volumes of IkB alpha, Activated, 6-His-tag recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS636204 is a recombinant protein targeting IkB alpha, Activated, 6-His-tag. Also known as IkB alpha, Activated, Recombinant, Human, 6-His-tag (NF-kappa-B Inhibitor alpha, I-kappa-B-alpha, IkB-alpha, IkappaBalpha, Major Histocompatibility Complex Enhancer-binding Protein MAD3, NFKBIA, IKBA, MAD3, NFKBI). Reactive in Human.