RXR Alpha, Aa111-228 (rxrga) Recombinant Protein

Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The rar/rxr heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for rxrs is 9-cis retinoic acid

By similarity. Ref.1

Subunit structure: Homodimer

By similarity. Heterodimer; with a rar molecule

By similarity. Binds DNA preferentially as a rar/rxr heterodimer

By similarity. Heterodimerizes with rarga. Ref.1

Subcellular location: Nucleus

By similarity.

Tissue specificity: Uniformly expressed from the blastula to mid-gastrula stages. In late gastrula stages, there is specific expression in the presumptive hindbrain and spinal cord. At 16 hours post-fertilization (hpf), expressed in the hindbrain from rhombomere 7/8 to the anterior spinal cord; this expression continues until 42 hpf. At 24 hpf, also expressed in the lateral plate mesoderm flanking rhombomere 6 and in the cranial neural crest, but not in the migrating crest. At 26 hpf, also expressed in retina. At 48 hpf, strong retinal expression. Ref.1 Ref.4

Developmental stage: Expressed both maternally and zygotically. Ref.1 Ref.3 Ref.4

Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.

Sequence similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain.