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VGLU2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6362574

MBS6362574 is an antibody targeting VGLU2. Also known as VGLU2, CT (Slc17a6, Dnpi, Vglut2, Vesicular glutamate transporter 2, Differentiation-associated BNPI, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family… More details

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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
VGLU2, Polyclonal Antibody
Full Product Name
VGLU2, CT (Slc17a6, Dnpi, Vglut2, Vesicular glutamate transporter 2, Differentiation-associated BNPI, Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter, Solute carrier family 17 member 6) (MaxLight 750)
Product Gene Name
anti-VGLU2 antibody
Product Synonym Gene Name
Slc17a6
Product Synonym Names
Slc17a6; Dnpi; Vglut2; Vesicular glutamate transporter 2; Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Mouse, Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes mouse VGLU2. Species Crossreactivity: human
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
64,561 Da
3D Structure
ModBase 3D Structure for Q8BLE7
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 507-535 in the C-terminal region of mouse VGLU2, Swiss/UniProt Accession: Q8BLE7. Species sequence homology: bovine, rat
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-VGLU2 antibody

Antibodies; Transport Proteins
Applications Tested/Suitable for anti-VGLU2 antibody
Immunohistochemistry (IHC) Paraffin, FLISA, Western Blot (WB)
Application Notes for anti-VGLU2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-VGLU2 antibody

Western Blot analysis in mouse cerebellum, brain tissue lysates (35ug/lane) usingMBS6004735. VGLU2 (arrow) was detected usingMBS6004735.
Rabbit Anti-VGLU2 Polyclonal Antibody – Cat# MBS6362574

Testing Data of anti-VGLU2 antibody

All lanes: MBS6004735 (1:1000-1:2000) Lane 1: Human brain lysate Lane 2: Human fetal brain lysate Lane 3: Human cerebellum lysate Lane 4: Mouse cerebellum lysate Lysates/proteins at 20ug/lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 65kD. Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-VGLU2 Polyclonal Antibody, Testing Data – Cat# MBS6362574

Testing Data of anti-VGLU2 antibody

All lanes: MBS6004735 (1:2000) Lane 1: Human fetal brain lysate Lane 2: Human cerebellum lysate Lysates/proteins at 20ug/lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10,000. Predicted band size: 65kD. Blocking/Dilution buffer: 5% NFDM/TBST.
Rabbit Anti-VGLU2 Polyclonal Antibody, Testing Data – Cat# MBS6362574

Immunohistochemistry (IHC) of anti-VGLU2 antibody

Formalin-fixed and paraffin-embedded human brain reacted withMBS6004735, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of MBS6004735 for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-VGLU2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6362574

Product References and Citations for anti-VGLU2 antibody

1. Birgner, C., et.al., Proc. Natl. Acad. Sci. U.S.A. 107 (1), 389-394 (2010). 2. Renier, N., et.al., PLoS Biol. 8 (3), E1000325 (2010). 3. Rose, M.F., et.al., Proc. Natl. Acad. Sci. U.S.A. 106 (52), 22462-22467 (2009).

Other Notes

Small volumes of anti-VGLU2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VGLU2. It may not necessarily be applicable to this product.

NCBI GI #
188219544
NCBI GeneID
140919
NCBI Accession #
NP_543129.3
UniProt Primary Accession #
Q8BLE7
UniProt Secondary Accession #
Q920B7
UniProt Related Accession #
Q8BLE7
GenBank Nucleotide #
NM_080853.3
NCBI Official Full Name
vesicular glutamate transporter 2
NCBI Official Synonym Full Names
solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6
NCBI Official Symbol
Slc17a6
NCBI Official Synonym Symbols
DNPI; VGLUT2; 2900073D12Rik
UniProt Protein Name
Vesicular glutamate transporter 2
UniProt Synonym Protein Names
Differentiation-associated BNPI; Differentiation-associated Na(+)-dependent inorganic phosphate cotransporter; Solute carrier family 17 member 6
UniProt Gene Name
Slc17a6
UniProt Synonym Gene Names
Dnpi; Vglut2; VGluT2
UniProt Entry Name
VGLU2_MOUSE
NCBI Protein Information
vesicular glutamate transporter 2; differentiation-associated BNPI; solute carrier family 17 member 6; solute carrier family 17 (vesicular glutamate transporter), member 6; differentiation-associated Na(+)-dependent inorganic phosphate cotransporter

UniProt Comments for VGLU2

SLC17A6: Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate. Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.

Protein type: Transporter, SLC family; Membrane protein, multi-pass; Transporter; Membrane protein, integral

Cellular Component: synaptic vesicle; neuron projection; membrane; early endosome; integral to membrane; synapse; cytoplasmic vesicle; cell junction

Molecular Function: symporter activity; L-glutamate transmembrane transporter activity

Biological Process: neurotransmitter transport; transport; sodium ion transport; neurotransmitter uptake; ion transport; transmembrane transport
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Research Articles on VGLU2

1. VGLUT2 was found to be co-localized with muscarinic receptors on intraganglionic laminar endings of esophagus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-VGLU2 antibody

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 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram
 Synaptic Vesicle Cycle Pathway antibodies  Synaptic Vesicle Cycle Pathway Diagram

Diseases associated with anti-VGLU2 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >38 publications with VGLU2 and Nervous System Diseases
 Pain Antibodies  >18 publications with VGLU2 and Pain
 Brain Diseases Antibodies  >18 publications with VGLU2 and Brain Diseases
 Movement Disorders Antibodies  >9 publications with VGLU2 and Movement Disorders
 Basal Ganglia Diseases Antibodies  >9 publications with VGLU2 and Basal Ganglia Diseases
 Drug Toxicity Antibodies  >7 publications with VGLU2 and Drug Toxicity
 Epilepsy Antibodies  >5 publications with VGLU2 and Epilepsy
 Dyskinesias Antibodies  >4 publications with VGLU2 and Dyskinesias
 Cardiovascular Diseases Antibodies  >4 publications with VGLU2 and Cardiovascular Diseases
 Ataxia Antibodies  >4 publications with VGLU2 and Ataxia

Organs/Tissues associated with anti-VGLU2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >243 publications with VGLU2 and Brain
 Spinal Cord Antibodies  >54 publications with VGLU2 and Spinal Cord
 Eye Antibodies  >12 publications with VGLU2 and Eye
 Dorsal Root Ganglion Antibodies  >9 publications with VGLU2 and Dorsal Root Ganglion
 Embryonic Tissue Antibodies  >6 publications with VGLU2 and Embryonic Tissue
 Olfactory Mucosa Antibodies  >2 publications with VGLU2 and Olfactory Mucosa
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