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VTI1B Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6362926

V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be… More details

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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
VTI1B, Polyclonal Antibody
Full Product Name
VTI1B, ID (VTI1B, VTI1, VTI1L, VTI1L1, VTI2, Vesicle transport through interaction with t-SNAREs homolog 1B, Vesicle transport v-SNARE protein Vti1-like 1, Vti1-rp1) (MaxLight 750)
Product Gene Name
anti-VTI1B antibody
Product Synonym Names
VTI1B; VTI1; VTI1L; VTI1L1; VTI2; Vesicle transport through interaction with t-SNAREs homolog 1B; Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
26,688 Da
Chromosome Location
Chromosome: 14; NC_000014.8 (68117866..68141602, complement). Location: 14q24.1
OMIM
603207
3D Structure
ModBase 3D Structure for Q9UEU0
Immunogen
VTI1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human VTI1B.
Conjugate
MaxLight750
Note
Preservative Free

Product Categories/Family for anti-VTI1B antibody

Antibodies; Transport Proteins
Applications Tested/Suitable for anti-VTI1B antibody
Western Blot (WB), FLISA
Application Notes for anti-VTI1B antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-VTI1B antibody

Furuta, N., et al. Mol. Biol. Cell 21(6):1001-1010(2010). Bilan, F., et al. Exp. Cell Res. 314 (11-12), 2199-2211 (2008): Hirst, J., et al. Mol. Biol. Cell 15(12):5593-5602(2004). Yan, Q., et al. J. Biol. Chem. 279(18):18270-18276(2004). Martinez-Arca, S., et al. Proc. Natl. Acad. Sci. U.S.A. 100(15):9011-9016(2003).

Other Notes

Small volumes of anti-VTI1B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VTI1B purchase

MBS6362926 is an antibody targeting VTI1B. Also known as VTI1B, ID (VTI1B, VTI1, VTI1L, VTI1L1, VTI2, Vesicle transport through interaction with t-SNAREs homolog 1B, Vesicle transport v-SNARE protein Vti1-like 1, Vti1-rp1) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VTI1B. It may not necessarily be applicable to this product.

NCBI GI #
5454166
NCBI GeneID
10490
NCBI Accession #
NP_006361.1
UniProt Primary Accession #
Q9UEU0
UniProt Secondary Accession #
O43547; Q96J28
UniProt Related Accession #
Q9UEU0
GenBank Nucleotide #
NM_006370.2
NCBI Official Full Name
vesicle transport through interaction with t-SNAREs homolog 1B
NCBI Official Synonym Full Names
vesicle transport through interaction with t-SNAREs 1B
NCBI Official Symbol
VTI1B
NCBI Official Synonym Symbols
VTI1; VTI2; VTI1L; v-SNARE; vti1-rp1; VTI1-LIKE
UniProt Protein Name
Vesicle transport through interaction with t-SNAREs homolog 1B
UniProt Synonym Protein Names
Vesicle transport v-SNARE protein Vti1-like 1; Vti1-rp1
Protein Family
Vesicle transport through interaction with t-SNAREs
UniProt Gene Name
VTI1B
UniProt Synonym Gene Names
VTI1; VTI1L; VTI1L1; VTI2
UniProt Entry Name
VTI1B_HUMAN
NCBI Protein Information
vesicle transport through interaction with t-SNAREs homolog 1B; vesicle transport v-SNARE protein Vti1-like 1; vesicle-associated soluble NSF attachment protein receptor

UniProt Comments for VTI1B

VTI1B: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q24.1

Cellular Component: SNARE complex; Golgi apparatus; endoplasmic reticulum membrane; recycling endosome; synaptic vesicle; cell soma; intracellular membrane-bound organelle; late endosome membrane; lysosomal membrane; perinuclear region of cytoplasm; cytoplasm; integral to membrane; vesicle

Molecular Function: SNAP receptor activity; SNARE binding; chloride channel inhibitor activity

Biological Process: vesicle-mediated transport; cell proliferation; intra-Golgi vesicle-mediated transport; ER to Golgi vesicle-mediated transport; autophagic vacuole fusion; Golgi to vacuole transport; vesicle fusion with Golgi apparatus; protein targeting to vacuole; retrograde transport, endosome to Golgi; vesicle docking during exocytosis
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Research Articles on VTI1B

1. Vti1b-dependent tethering of Lytic granule and CD3-endo determines accumulation, docking, and efficient lytic granule secretion at the immunological synapse.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VTI1B antibody

 Reference Product  PubMed Publications
 STX8 antibody  >3 publications with VTI1B and STX8
 STX7 antibody  >3 publications with VTI1B and STX7

Pathways associated with anti-VTI1B antibody

 Products by Pathway  Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram
 SNARE Interactions In Vesicular Transport Pathway antibodies  SNARE Interactions In Vesicular Transport Pathway Diagram

Diseases associated with anti-VTI1B antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >2 publications with VTI1B and Neoplasms
 Stroke Antibodies  >1 publications with VTI1B and Stroke
 Disease Models, Animal Antibodies  >1 publications with VTI1B and Disease Models, Animal
 Breast Neoplasms Antibodies  >1 publications with VTI1B and Breast Neoplasms
 Necrosis Antibodies  >1 publications with VTI1B and Necrosis
 Inflammation Antibodies  >1 publications with VTI1B and Inflammation

Organs/Tissues associated with anti-VTI1B antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >5 publications with VTI1B and Blood
 Nerve Antibodies  >3 publications with VTI1B and Nerve
 Bone Antibodies  >2 publications with VTI1B and Bone
 Liver Antibodies  >2 publications with VTI1B and Liver
 Bone Marrow Antibodies  >2 publications with VTI1B and Bone Marrow
 Lung Antibodies  >2 publications with VTI1B and Lung
 Brain Antibodies  >2 publications with VTI1B and Brain
 Vascular Antibodies  >1 publications with VTI1B and Vascular
 Ganglia Antibodies  >1 publications with VTI1B and Ganglia
 Salivary Gland Antibodies  >1 publications with VTI1B and Salivary Gland
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