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KIR2DL1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636295

An inhibitory Killer Cell Ig-like Receptor(KIR, previously called p58 KIR, p58.1, cl-42, NKAT1, or KIR-K6), which recognizes class I MHC molecules(HLA-Cw2, -Cw4, -Cw5, and Cw6). The extracellular domain of KIR2DL1 was over expressed as insoluble protein… More details

$680 / 0.005 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KIR2DL1, Recombinant Protein
Full Product Name
KIR2DL1, Recombinant, Human (p58 KIR, p58.1, CD158, cl-42, KIR-K6, NKAT1, NKR-K6, Killer Cell Immunoglobulin (Ig)-like Receptor)
Product Gene Name
KIR2DL1 recombinant protein
Sequence
MEGVHRKPSL LAHPGRLVKS EETVILQCWS DVMFEHFLLH REGMFNDTLR LIGEHHDGVS KANFSISRMT QDLAGTYRCY GSVTHSPYQV SAPSDPLDIV IIGLYEKPSL SAQLGPTVLA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAGPKVNGTF QADFPLGPAT HGGTYRCFGS FHDSPYEWSK SSDPLLVSVT GN
Host
E Coli
Form/Format
Supplied as a liquid in 25mM Tris-HCl, pH 7.5.
Purity/Purification
Highly Purified
95% as determined by RP-HPLC, anion-exchange FPLC and/or reducing and non-reducing SDS-PAGE Silver Stained gel.
Preparation and Storage
-20 degree C
Stability: Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Molecular Weight
22.2kD
Chromosome Location
Chromosome: 19; NC_000019.9 (55281265..55295778). Location: 19q13.4
OMIM
604936
3D Structure
ModBase 3D Structure for P43626

Product Categories/Family for KIR2DL1 recombinant protein

Molecular Biology; MB-Receptors

Other Notes

Small volumes of KIR2DL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KIR2DL1 purchase

MBS636295 is a recombinant protein targeting KIR2DL1. Also known as KIR2DL1, Recombinant, Human (p58 KIR, p58.1, CD158, cl-42, KIR-K6, NKAT1, NKR-K6, Killer Cell Immunoglobulin (Ig)-like Receptor). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for KIR2DL1. It may not necessarily be applicable to this product.

NCBI GI #
93359503
NCBI GeneID
3802
NCBI Accession #
ABF13296.1
UniProt Primary Accession #
P43626
UniProt Secondary Accession #
O43470; Q32WE6
UniProt Related Accession #
P43626
NCBI Official Full Name
KIR2DL1
NCBI Official Synonym Full Names
killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1
NCBI Official Symbol
KIR2DL1
NCBI Official Synonym Symbols
NKAT; NKAT1; p58.1; CD158A; KIR221; KIR-K64
UniProt Protein Name
Killer cell immunoglobulin-like receptor 2DL1
UniProt Synonym Protein Names
CD158 antigen-like family member A; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor
Protein Family
Killer cell immunoglobulin-like receptor
UniProt Gene Name
KIR2DL1
UniProt Synonym Gene Names
CD158A; NKAT1; NKAT-1
UniProt Entry Name
KI2L1_HUMAN
NCBI Protein Information
killer cell immunoglobulin-like receptor 2DL1; NKAT-1; killer Ig receptor; p58 NK receptor CL-42/47.11; MHC class I NK cell receptor; killer inhibitory receptor 2-2-1; CD158 antigen-like family member A; natural killer-associated transcript 1; p58 NK cell inhibitory receptor NKR-K6; p58.1 MHC class-I-specific NK receptor; p58 killer cell inhibitory receptor KIR-K64; p58 natural killer cell receptor clones CL-42/47.11

NCBI Summary for KIR2DL1

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]
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UniProt Comments for KIR2DL1

KIR2DL1: Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis. Interacts with ARRB2. Interacts with PTPN6; the interaction is enhanced by ARRB2. Interacts with PTPN11; the interaction is enhanced by ARRB2. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; receptor activity

Biological Process: regulation of immune response; immune response; natural killer cell inhibitory signaling pathway
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Research Articles on KIR2DL1

1. NK cells were isolated from peripheral blood and the lysis of KG1A and K562 cells by the NK cells was analyzed to investigate whether KIR2DL1 expression on NK cells would affect the cytotoxicity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with KIR2DL1 recombinant protein

 Reference Product  PubMed Publications
 HLA-C recombinant protein  >103 publications with KIR2DL1 and HLA-C
 HLA-A recombinant protein  >19 publications with KIR2DL1 and HLA-A
 PTPN6 recombinant protein  >3 publications with KIR2DL1 and PTPN6
 PTPN11 recombinant protein  >3 publications with KIR2DL1 and PTPN11
 HLA-ABC recombinant protein  >1 publications with KIR2DL1 and HLA-ABC

Pathways associated with KIR2DL1 recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 Antigen Processing And Presentation Pathway antibodies  Antigen Processing And Presentation Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Graft-versus-host Disease Pathway antibodies  Graft-versus-host Disease Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies  Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Natural Killer Cell Mediated Cytotoxicity Pathway antibodies  Natural Killer Cell Mediated Cytotoxicity Pathway Diagram

Diseases associated with KIR2DL1 recombinant protein

 Disease Name  Pubmed Publications
 Chronic Disease Antibodies  >14 publications with KIR2DL1 and Chronic Disease
 Skin Neoplasms Antibodies  >8 publications with KIR2DL1 and Skin Neoplasms
 Necrosis Antibodies  >6 publications with KIR2DL1 and Necrosis
 Lung Neoplasms Antibodies  >3 publications with KIR2DL1 and Lung Neoplasms
 Bronchial Neoplasms Antibodies  >2 publications with KIR2DL1 and Bronchial Neoplasms
 Bone Neoplasms Antibodies  >2 publications with KIR2DL1 and Bone Neoplasms
 Kidney Diseases Antibodies  >2 publications with KIR2DL1 and Kidney Diseases
 Leukemia-Lymphoma, Adult T-Cell Antibodies  >1 publications with KIR2DL1 and Leukemia-Lymphoma, Adult T-Cell
 Colorectal Neoplasms Antibodies  >1 publications with KIR2DL1 and Colorectal Neoplasms
 Multiple Myeloma Antibodies  >1 publications with KIR2DL1 and Multiple Myeloma
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