TDO2 Recombinant Protein – Cat# MBS636348

15% SDS-PAGE using T9013-95H (3ug)

Tryptophan 2,3-Dioxygenase, Aa1-406 (TDO2) Recombinant Protein

Name: TDO2 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS636348
Price: 790 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636348

TDO2, also known as TDO, is a ferrous heme enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism. It incorporates oxygen into the indole moiety of tryptophan. It has a broad specificity… More details

$790 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Tryptophan 2,3-Dioxygenase, aa1-406 (TDO2), Recombinant Protein

Full Product Name

Tryptophan 2,3-Dioxygenase, aa1-406, Recombinant, Human (TDO, TDO2, TPH2, Tryptamin 2,3-dioxygenase, Tryptophan Oxygenase, TO, TRPO, Tryptophan Pyrrolase, Tryptophanase)

Product Gene Name

TDO2 recombinant protein

Host

E Coli

Form/Format

Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, 0.2M sodium chloride, 5mM DTT, 1mM EDTA, 30% glycerol.

Purity/Purification

Highly Purified
~90% (SDS-PAGE)

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~50.0kD

Chromosome Location

Chromosome: 4; NC_000004.11 (156824845..156841558). Location: 4q31-q32

OMIM

191070

3D Structure

ModBase 3D Structure for P48775

Product Categories/Family for TDO2 recombinant protein

Molecular Biology; MB-Enzymes; Oxidase

Other Notes

Small volumes of TDO2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TDO2 purchase

MBS636348 is a recombinant protein targeting TDO2. Also known as Tryptophan 2,3-Dioxygenase, aa1-406, Recombinant, Human (TDO, TDO2, TPH2, Tryptamin 2,3-dioxygenase, Tryptophan Oxygenase, TO, TRPO, Tryptophan Pyrrolase, Tryptophanase). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for TDO2. It may not necessarily be applicable to this product.

NCBI GI #

5032165

NCBI GeneID

6999

NCBI Accession #

NP_005642.1

UniProt Primary Accession #

P48775

UniProt Secondary Accession #

A8K053

UniProt Related Accession #

P48775

GenBank Nucleotide #

NM_005651.3

NCBI Official Full Name

tryptophan 2,3-dioxygenase

NCBI Official Synonym Full Names

tryptophan 2,3-dioxygenase

NCBI Official Symbol

TDO2

NCBI Official Synonym Symbols

TO; TDO; TPH2; TRPO

UniProt Protein Name

Tryptophan 2,3-dioxygenase

UniProt Synonym Protein Names

Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

UniProt Gene Name

TDO2

UniProt Synonym Gene Names

TDO; TDO; TO; TRPO

UniProt Entry Name

T23O_HUMAN

NCBI Protein Information

tryptophan 2,3-dioxygenase; tryptophanase; tryptophan oxygenase; tryptophan pyrrolase; tryptamin 2,3-dioxygenase

NCBI Summary for TDO2

This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

UniProt Comments for TDO2

TDO2: Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin. Belongs to the tryptophan 2,3-dioxygenase family.

Protein type: Oxidoreductase; EC 1.13.11.11; Amino Acid Metabolism - tryptophan

Chromosomal Location of Human Ortholog: 4q31-q32

Cellular Component: cytosol

Molecular Function: amino acid binding; metal ion binding; heme binding; oxygen binding; tryptophan 2,3-dioxygenase activity

Biological Process: tryptophan catabolic process to acetyl-CoA; tryptophan catabolic process to kynurenine; tryptophan catabolic process

Research Articles on TDO2

1. Data suggest that T342 in hTDO has critical role in controlling substrate binding, substrate stereoselectivity, H-bonding interaction between enzyme and intermediates, and regulating the dynamics of protein structure.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TDO2 recombinant protein

Reference Product	PubMed Publications
IDO1 recombinant protein	>4 publications with TDO2 and IDO1

Pathways associated with TDO2 recombinant protein

Products by Pathway	Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Monoamine Transport Pathway antibodies	Monoamine Transport Pathway Diagram
NAD Biosynthesis II (from Tryptophan) Pathway antibodies	NAD Biosynthesis II (from Tryptophan) Pathway Diagram
NAD Biosynthesis II (from Tryptophan) Pathway antibodies	NAD Biosynthesis II (from Tryptophan) Pathway Diagram
Tryptophan Catabolism Pathway antibodies	Tryptophan Catabolism Pathway Diagram
Tryptophan Metabolism Pathway antibodies	Tryptophan Metabolism Pathway Diagram
Tryptophan Metabolism Pathway antibodies	Tryptophan Metabolism Pathway Diagram
Tryptophan Metabolism Pathway antibodies	Tryptophan Metabolism Pathway Diagram
Tryptophan Degradation III (eukaryotic) Pathway antibodies	Tryptophan Degradation III (eukaryotic) Pathway Diagram

Diseases associated with TDO2 recombinant protein

Disease Name	Pubmed Publications
Brain Diseases Antibodies	>7 publications with TDO2 and Brain Diseases
Nervous System Diseases Antibodies	>5 publications with TDO2 and Nervous System Diseases
Learning Disorders Antibodies	>2 publications with TDO2 and Learning Disorders
Disease Models, Animal Antibodies	>1 publications with TDO2 and Disease Models, Animal
Weight Loss Antibodies	>1 publications with TDO2 and Weight Loss
Memory Disorders Antibodies	>1 publications with TDO2 and Memory Disorders
Inflammation Antibodies	>1 publications with TDO2 and Inflammation
Autistic Disorder Antibodies	>1 publications with TDO2 and Autistic Disorder

Organs/Tissues associated with TDO2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>5 publications with TDO2 and Liver