Capillary Morphogenesis Gene 2 Active Protein

Name: Active Protein; Capillary Morphogenesis Gene 2; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS636510
Price: 1110 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636510

Capillary Morphogenesis Gene-2 (CMG-2) is a widely expressed anthrax toxin receptor (ATR) family protein (1-4). CMG-2 is a ~55 kD protein that contains a 31 amino acid (aa) signal sequence, a 287 aa extracellular domain (ECD), a 21 aa transmembrane sequence,… More details

$1110 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Capillary Morphogenesis Gene 2, Active Protein

Full Product Name

Capillary Morphogenesis Gene 2, Recombinant, Mouse (CMG-2, Anthrax Toxin Receptor 2, ANTXR2)

Form/Format

Supplied as a lyophilized powder in PBS containing 50ug of BSA per 1ug of cytokine.

Purity/Purification

Highly Purified
95%, as determined by SDS-PAGE and visualized by silver stain.

Preparation and Storage

Lyophilized samples are stable for up to twelve months from date of receipt at -20 degree C. Upon reconstitution, this protein, in the presence of a carrier protein, can be stored under sterile conditions at 2-8 degree C for one month or at -20 degree C in a manual defrost freezer for three months without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Molecular Weight

The mature recombinant mouse CMG-2 contains 299 amino acid residues with a calculated molecular mass of approximately 32 kD. As a result of glycosylation, the recombinant protein migrates as an approximately 32-35 kD protein in SDS-PAGE under reducing con

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Activity

Measured by its ability to bind anthrax protective antigen (PA) in a functional ELISA (Scobie H.M. et al., 2003, Proc. Natl. Acad. Sci. USA 100:5170). Immobilized PA at 1.5ug/ml (100 L/well) can bind rmCMG-2 with a linear range of 0.08-5.0ug/ml in a functional ELISA assay.

Endotoxin Level

< 1.0 EU per 1 g of the protein as determined by the LAL method.

Reconstitution

It is recommended that sterile PBS containing at least 0.1% human serum albumin or bovine serum albumin be added to the vial to prepare a stock solution of no less than 10ug/ml.

Product Categories/Family for Capillary Morphogenesis Gene 2 active protein

Molecular Biology; MB-Receptors

Other Notes

Small volumes of Capillary Morphogenesis Gene 2 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Capillary Morphogenesis Gene 2 purchase

MBS636510 is an active protein targeting Capillary Morphogenesis Gene 2. Also known as Capillary Morphogenesis Gene 2, Recombinant, Mouse (CMG-2, Anthrax Toxin Receptor 2, ANTXR2).

Additional Details

NCBI/Uniprot data below describe general gene information for Capillary Morphogenesis Gene 2. It may not necessarily be applicable to this product.

NCBI GI #

30013741

NCBI Accession #

AAP04016.1

NCBI Official Full Name

capillary morphogenesis protein 2

NCBI Summary for Capillary Morphogenesis Gene 2

This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

UniProt Comments for Capillary Morphogenesis Gene 2

ANTXR2: Necessary for cellular interactions with laminin and the extracellular matrix. Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH). This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures. Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF). JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 4q21.21

Cellular Component: endoplasmic reticulum membrane; integral to membrane; plasma membrane; extracellular region; endosome membrane; external side of plasma membrane

Molecular Function: protein binding; metal ion binding; receptor activity

Biological Process: reproductive process; pathogenesis

Disease: Hyaline Fibromatosis Syndrome

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.