VAMP8 Recombinant Protein – Cat# MBS636560

15% SDS-PAGE using MBS636560

VAMP 8, Aa1-76 (VAMP8) Recombinant Protein

Name: VAMP8 Recombinant Protein; VAMP 8, Aa1-76; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS636560
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636560

Vehicle-associated membrane (VAMP8),also known as endobrevin, is the main components of a SNARE complex involved in the docking and fusion of synaptic vesicles with the presynaptic membrane. This protein plays a role in regulated enzyme secretion in… More details

$755 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

VAMP 8, aa1-76 (VAMP8), Recombinant Protein

Full Product Name

VAMP 8, aa1-76, Recombinant (Vesicle-Associated Membrane Protein 8, Endobrevin 8)

Product Gene Name

VAMP8 recombinant protein

Product Synonym Names

Anti -VAMP 8, aa1-76, Recombinant (Vesicle-Associated Membrane Protein 8, Endobrevin 8)

Sequence

MGSSHHHHHH SSGLVPRGSH MEEASEGG GN DRVRNLQSEV EGVKNIMT QN VERILARGEN LEHLRNKT ED LEATSEHFKT TSQKVARK FW WKNVKM

Form/Format

Supplied as a liquid in 20 mM Tris, pH 8.5, 0.2M Sodium chloride, 0.1mM PMSF, 0.1M Imidazole, 50% Glycerol

Purity/Purification

>90%. SDS-PAGE under reducing conditions and visualized by coomassie blue stain

Concentration

0.25mg/ml (lot specific)

Preparation and Storage

May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20°C. Aliquots are stable for 6 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer

Molecular Weight

10.9kD

Chromosome Location

Chromosome: 2; NC_000002.11 (85804614..85809156). Location: 2p12-p11.2

OMIM

603177

3D Structure

ModBase 3D Structure for Q9BV40

Source

Recombinant protein corresponding to aa1-76 from VAMP8 with a His-Tag. expressed in E.coli. Uniprot/Accession: NP_003752

Product Categories/Family for VAMP8 recombinant protein

Antibodies; Abs to Membrane Proteins

Other Notes

Small volumes of VAMP8 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VAMP8 purchase

MBS636560 is a recombinant protein targeting VAMP8. Also known as VAMP 8, aa1-76, Recombinant (Vesicle-Associated Membrane Protein 8, Endobrevin 8).

Additional Details

NCBI/Uniprot data below describe general gene information for VAMP8. It may not necessarily be applicable to this product.

NCBI GI #

14043026

NCBI GeneID

8673

NCBI Accession #

NP_003752.2

UniProt Primary Accession #

Q9BV40

UniProt Secondary Accession #

O60625; Q53SP9; Q6IB09

UniProt Related Accession #

Q9BV40

GenBank Nucleotide #

NM_003761.4

NCBI Official Full Name

vesicle-associated membrane protein 8

NCBI Official Synonym Full Names

vesicle-associated membrane protein 8

NCBI Official Symbol

VAMP8

NCBI Official Synonym Symbols

EDB; VAMP-8

UniProt Protein Name

Vesicle-associated membrane protein 8

UniProt Synonym Protein Names

Endobrevin

Protein Family

Vesicle-associated membrane protein

UniProt Gene Name

VAMP8

UniProt Synonym Gene Names

VAMP-8; EDB

UniProt Entry Name

VAMP8_HUMAN

NCBI Protein Information

vesicle-associated membrane protein 8; vesicle-associated membrane protein 8 (endobrevin)

NCBI Summary for VAMP8

This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010]

UniProt Comments for VAMP8

VAMP8: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Involved for dense-granule secretion in platelets. Plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Belongs to the synaptobrevin family.

Protein type: Vesicle; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12-p11.2

Cellular Component: cell surface; mitochondrion; secretory granule membrane; late endosome membrane; lysosomal membrane; early endosome; integral to membrane; cytosol; SNARE complex; recycling endosome; membrane; perinuclear region of cytoplasm; cytoplasm; plasma membrane; vesicle

Molecular Function: SNAP receptor activity; SNARE binding; protein binding; chloride channel inhibitor activity; syntaxin binding

Biological Process: vesicle fusion; protein transport; entry of virus into host cell; exocytosis; autophagic vacuole fusion; regulation of endocytosis; neutrophil degranulation; eosinophil degranulation; endocytosis; post-Golgi vesicle-mediated transport

Research Articles on VAMP8

1. VAMP8 regulates mucin granule exocytosis in airway goblet cells, and reduction of its expression may provide a novel therapeutic target to ameliorate airway mucus obstruction in lung diseases

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VAMP8 recombinant protein

Reference Product	PubMed Publications
VAMP2 recombinant protein	>22 publications with VAMP8 and VAMP2
SNAP23 recombinant protein	>16 publications with VAMP8 and SNAP23
STX1A recombinant protein	>6 publications with VAMP8 and STX1A
STX3 recombinant protein	>3 publications with VAMP8 and STX3
STX8 recombinant protein	>2 publications with VAMP8 and STX8
STX7 recombinant protein	>2 publications with VAMP8 and STX7
STX2 recombinant protein	>1 publications with VAMP8 and STX2
STX6 recombinant protein	>1 publications with VAMP8 and STX6
STX4 recombinant protein	>1 publications with VAMP8 and STX4

Pathways associated with VAMP8 recombinant protein

Products by Pathway	Pathway Diagram
Clathrin Derived Vesicle Budding Pathway antibodies	Clathrin Derived Vesicle Budding Pathway Diagram
Golgi Associated Vesicle Biogenesis Pathway antibodies	Golgi Associated Vesicle Biogenesis Pathway Diagram
Lysosome Vesicle Biogenesis Pathway antibodies	Lysosome Vesicle Biogenesis Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
SNARE Interactions In Vesicular Transport Pathway antibodies	SNARE Interactions In Vesicular Transport Pathway Diagram
SNARE Interactions In Vesicular Transport Pathway antibodies	SNARE Interactions In Vesicular Transport Pathway Diagram
Trans-Golgi Network Vesicle Budding Pathway antibodies	Trans-Golgi Network Vesicle Budding Pathway Diagram

Diseases associated with VAMP8 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>9 publications with VAMP8 and Inflammation
Neoplasms Antibodies	>7 publications with VAMP8 and Neoplasms
Heart Diseases Antibodies	>6 publications with VAMP8 and Heart Diseases
Fibrosis Antibodies	>3 publications with VAMP8 and Fibrosis
Necrosis Antibodies	>3 publications with VAMP8 and Necrosis
Kidney Diseases Antibodies	>2 publications with VAMP8 and Kidney Diseases
Carcinoma Antibodies	>2 publications with VAMP8 and Carcinoma
Neoplasms, Experimental Antibodies	>1 publications with VAMP8 and Neoplasms, Experimental
Liver Neoplasms Antibodies	>1 publications with VAMP8 and Liver Neoplasms
Breast Neoplasms Antibodies	>1 publications with VAMP8 and Breast Neoplasms

Organs/Tissues associated with VAMP8 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>21 publications with VAMP8 and Blood
Pancreas Antibodies	>11 publications with VAMP8 and Pancreas
Liver Antibodies	>7 publications with VAMP8 and Liver
Kidney Antibodies	>6 publications with VAMP8 and Kidney
Bone Marrow Antibodies	>5 publications with VAMP8 and Bone Marrow
Bone Antibodies	>5 publications with VAMP8 and Bone
Eye Antibodies	>5 publications with VAMP8 and Eye
Lung Antibodies	>2 publications with VAMP8 and Lung
Larynx Antibodies	>2 publications with VAMP8 and Larynx
Intestine Antibodies	>2 publications with VAMP8 and Intestine