LAIR1 Recombinant Protein – Cat# MBS636605

LAIR-1, Aa22-125, Extracellular Domain (LAIR1) Recombinant Protein

Name: LAIR1 Recombinant Protein; MyBioSource
Brand: MyBioSource
SKU: MBS636605
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636605

LAIR-1 is a glycoprotein (~32kD) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells… More details

$650 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LAIR-1, aa22-125, Extracellular Domain (LAIR1), Recombinant Protein

Full Product Name

LAIR-1, aa22-125, Extracellular Domain, Recombinant, Human (Leukocyte-associated Ig-like Receptor-1)

Product Gene Name

LAIR1 recombinant protein

Host

E Coli

Form/Format

Supplied as a liquid in 20mM Tris-HCl, pH 7.5, 50mM sodium chloride, 1mM EDTA.

Purity/Purification

Highly Purified
95% (SDS PAGE)

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage, store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

11.7kD

Chromosome Location

Chromosome: 19; NC_000019.9 (54865235..54882241, complement). Location: 19q13.4

OMIM

602992

3D Structure

ModBase 3D Structure for Q6GTX8

Product Categories/Family for LAIR1 recombinant protein

Molecular Biology; MB-Receptors

Other Notes

Small volumes of LAIR1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LAIR1 purchase

MBS636605 is a recombinant protein targeting LAIR1. Also known as LAIR-1, aa22-125, Extracellular Domain, Recombinant, Human (Leukocyte-associated Ig-like Receptor-1). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for LAIR1. It may not necessarily be applicable to this product.

NCBI GI #

11231177

NCBI GeneID

3903

NCBI Accession #

NP_068352.1

UniProt Primary Accession #

Q6GTX8

UniProt Related Accession #

Q6GTX8

GenBank Nucleotide #

NM_021706.2

NCBI Official Full Name

leukocyte-associated immunoglobulin-like receptor 1 isoform b

NCBI Official Synonym Full Names

leukocyte-associated immunoglobulin-like receptor 1

NCBI Official Symbol

LAIR1

NCBI Official Synonym Symbols

CD305; LAIR-1

UniProt Protein Name

Leukocyte-associated immunoglobulin-like receptor 1

Protein Family

Leukocyte-associated immunoglobulin-like receptor

UniProt Gene Name

LAIR1

UniProt Synonym Gene Names

CD305; LAIR-1; hLAIR1

UniProt Entry Name

LAIR1_HUMAN

NCBI Protein Information

leukocyte-associated immunoglobulin-like receptor 1; hLAIR1; leukocyte-associated Ig-like receptor 1

NCBI Summary for LAIR1

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq, Jul 2008]

UniProt Comments for LAIR1

LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.4

Cellular Component: integral to membrane; plasma membrane

Molecular Function: protein binding

Biological Process: immune system process

Research Articles on LAIR1

1. C1q is a functional ligand for LAIR-1 restricting immune cell differentiation and activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with LAIR1 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>2 publications with LAIR1 and Inflammation
Hepatitis Antibodies	>1 publications with LAIR1 and Hepatitis
Liver Diseases Antibodies	>1 publications with LAIR1 and Liver Diseases
Neoplasms Antibodies	>1 publications with LAIR1 and Neoplasms

Organs/Tissues associated with LAIR1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>9 publications with LAIR1 and Blood
Bone Antibodies	>1 publications with LAIR1 and Bone
Lymph Node Antibodies	>1 publications with LAIR1 and Lymph Node
Bone Marrow Antibodies	>1 publications with LAIR1 and Bone Marrow
Intestine Antibodies	>1 publications with LAIR1 and Intestine
Connective Tissue Antibodies	>1 publications with LAIR1 and Connective Tissue
Placenta Antibodies	>1 publications with LAIR1 and Placenta
Lung Antibodies	>1 publications with LAIR1 and Lung
Uterus Antibodies	>1 publications with LAIR1 and Uterus