Heparan Sulfate 2-O-Sulfotransferase 1 Human (HS2ST1) Active Protein

Name: HS2ST1 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS636651
Price: 1260 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636651

Heparan sulfate is a highly sulfated polysaccharide found on the cell surface and within the extracellular matrix. Typically, it is covalently attached to the protein core of proteoglycans, such as syndecans and glypicans. Heparin, on the other hand, can be… More details

$1260 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Heparan Sulfate 2-O-sulfotransferase 1 Human (HS2ST1), Active Protein

Full Product Name

Heparan Sulfate 2-O-sulfotransferase 1, Recombinant Human, (HS2ST1, HS2ST, 2-O-sulfotransferase, 2OST, dJ604K5.2, FLJ11317, KIAA0448, MGC131986)

Product Gene Name

HS2ST1 active protein

Form/Format

Supplied as a liquid in Tris and sodium chloride.

Purity/Purification

Purified
~90% (SDS-PAGE)

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~36kD

Chromosome Location

Chromosome: 1; NC_000001.10 (87380335..87575681). Location: 1p22.3

OMIM

604844

3D Structure

ModBase 3D Structure for Q7LGA3

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Measured by its ability to transfer sulfate from PAPS to heparan sulfate. The specific activity is > 20 pmoles/min/ug, as measured under the described conditions.

Endotoxin Level

<1EU/ug (LAL method)

Product Categories/Family for HS2ST1 active protein

Molecular Biology; MB-Enzymes; Sulfotransferase

Other Notes

Small volumes of HS2ST1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HS2ST1 purchase

MBS636651 is an active protein targeting HS2ST1. Also known as Heparan Sulfate 2-O-sulfotransferase 1, Recombinant Human, (HS2ST1, HS2ST, 2-O-sulfotransferase, 2OST, dJ604K5.2, FLJ11317, KIAA0448, MGC131986).

Additional Details

NCBI/Uniprot data below describe general gene information for HS2ST1. It may not necessarily be applicable to this product.

NCBI GI #

6912420

NCBI GeneID

9653

NCBI Accession #

NP_036394.1

UniProt Primary Accession #

Q7LGA3

UniProt Secondary Accession #

O75036; Q32NB5; Q8TAC5; Q9H441; Q9NUJ9; D3DT22

UniProt Related Accession #

Q7LGA3

GenBank Nucleotide #

NM_012262.3

NCBI Official Full Name

heparan sulfate 2-O-sulfotransferase 1 isoform 1

NCBI Official Synonym Full Names

heparan sulfate 2-O-sulfotransferase 1

NCBI Official Symbol

HS2ST1

NCBI Official Synonym Symbols

dJ604K5.2

UniProt Protein Name

Heparan sulfate 2-O-sulfotransferase 1

Protein Family

Heparan sulfate 2-O-sulfotransferase

UniProt Gene Name

HS2ST1

UniProt Synonym Gene Names

HS2ST; KIAA0448; 2-O-sulfotransferase; 2OST

UniProt Entry Name

HS2ST_HUMAN

NCBI Protein Information

heparan sulfate 2-O-sulfotransferase 1; 2OST

NCBI Summary for HS2ST1

Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]

UniProt Comments for HS2ST1

HS2ST1: Catalyzes the transfer of sulfate to the C2-position of selected hexuronic acid residues within the maturing heparan sulfate (HS). 2-O-sulfation within HS, particularly of iduronate residues, is essential for HS to participate in a variety of high- affinity ligand-binding interactions and signaling processes. Mediates 2-O-sulfation of both L-iduronyl and D-glucuronyl residues. Belongs to the sulfotransferase 3 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transferase; EC 2.8.2.-; Motility/polarity/chemotaxis; Membrane protein, integral; Glycan Metabolism - heparan sulfate biosynthesis

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: Golgi membrane; membrane; integral to membrane

Molecular Function: sulfotransferase activity

Biological Process: glycosaminoglycan biosynthetic process; glycosaminoglycan metabolic process; carbohydrate metabolic process; pathogenesis

Research Articles on HS2ST1

1. Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HS2ST1 active protein

Reference Product	PubMed Publications
HS3ST2 active protein	>1 publications with HS2ST1 and HS3ST2
GLCE active protein	>1 publications with HS2ST1 and GLCE
HS3ST6 active protein	>1 publications with HS2ST1 and HS3ST6

Pathways associated with HS2ST1 active protein

Products by Pathway	Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies	Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway antibodies	Glycosaminoglycan Biosynthesis - Heparan Sulfate / Heparin Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
HS-GAG Biosynthesis Pathway antibodies	HS-GAG Biosynthesis Pathway Diagram
Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies	Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram
MPS I - Hurler Syndrome Pathway antibodies	MPS I - Hurler Syndrome Pathway Diagram
MPS II - Hunter Syndrome Pathway antibodies	MPS II - Hunter Syndrome Pathway Diagram
MPS IIIA - Sanfilippo Syndrome A Pathway antibodies	MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
MPS IIIB - Sanfilippo Syndrome B Pathway antibodies	MPS IIIB - Sanfilippo Syndrome B Pathway Diagram

Diseases associated with HS2ST1 active protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with HS2ST1 and Neoplasms
Mammary Neoplasms, Animal Antibodies	>1 publications with HS2ST1 and Mammary Neoplasms, Animal
Fibrosis Antibodies	>1 publications with HS2ST1 and Fibrosis
Breast Neoplasms Antibodies	>1 publications with HS2ST1 and Breast Neoplasms
Neoplasm Metastasis Antibodies	>1 publications with HS2ST1 and Neoplasm Metastasis
Neoplasms, Experimental Antibodies	>1 publications with HS2ST1 and Neoplasms, Experimental

Organs/Tissues associated with HS2ST1 active protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>1 publications with HS2ST1 and Bone
Blood Antibodies	>1 publications with HS2ST1 and Blood
Eye Antibodies	>1 publications with HS2ST1 and Eye
Mammary Gland Antibodies	>1 publications with HS2ST1 and Mammary Gland