Dectin 2a Active Protein

Dectin-2, also known as CLEC6A, CLECSF10, and NKCL, belongs to the C-type lectin family of transmembrane immune regulatory glycoproteins. Dectin-2, CLEC4A/DCIR, CLEC4B/DCAR, CLEC4C/DLEC, CLEC4D/MCL, and CLEC4E/mincle constitute a subgroup of these molecules that exhibit approximately 40% aa sequence identity in their extracellular domains (ECD) and have a conserved cysteine spacing in their carbohydrate recognition domains (CRD). 1,2 Mature mouse dectin-2 consists of a short cytoplasmic tail, a transmembrane segment, and an ECD with a stalk region and one CRD. 3,4 Alternate splicing leads to partial deletion of the transmembrane segment and stalk (isoform) or a portion of the CRD (isoform). 4 The full length dectin-2 isoform is a 27 kD molecule that is primarily expressed on the surface of tissue macrophages and their precursors. 3-6 The CRD of dectin-2 contains an EPN motif which is characteristic of calcium-dependent mannose-binding lectins. Dectin-2 selectively interacts with high mannose structures in the Man9GlcNAc2 configuration. 7 It mediates the recognition of a variety of microorganisms, particularly the filamentous forms of yeast and fungii. 7,8 The short cytoplasmic tail does not contain signaling motifs but mediates association with the ITAM-containing Fc receptor subunit in macrophages. 8 Ligation of dectin-2 induces tyrosine phosphorylation of the subunit, activation of NF B, and enhanced release of TNF- and IL-1ra. 8 Macrophage dectin-2 is upregulated in vivo by inflammatory stimuli and UV-B irradiation. 6 It mediates the breaking of UV-induced tolerance by interacting with CD4+ CD25+ regulatory T cells which then induce dendritic cells to release IL-4, IL-10, and TGF-. 9 Within the ECD, mouse dectin-2 shares 71% aa sequence identity with human and bovine dectin-2.

Small volumes of Dectin 2a active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS636707 is an active protein targeting Dectin 2a. Also known as Dectin 2a, Recombinant, Mouse (CLEC6A, CLECSF10, NKCL).