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Fas:fc (FAIM3) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636741

FasL is a cytokine that binds to Fas/TNFRSF6, a receptor that transduces the apoptotic signal into cells. FasL is involved in cytotoxic T cell mediated apoptosis and in T cell development. More details

$610 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Fas:Fc (FAIM3), Active Protein
Full Product Name
Fas:Fc, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 6, TNFRSF6, Apo-1 Antigen, CD95)
Product Gene Name
Sequence
The Fc portion of human IgG1 is fused to the C-terminus of human Fas (aa 26-170).
Host
Human, HEK 293 cells
Form/Format
Supplied as a lyophilized powder from a 0.2um filtered solution in PBS pH 7.2.
Purity/Purification
Highly Purified
>95% (SDS-PAGE)
Specificity
Binds human and mouse FasL.
Preparation and Storage
Short-term Storage: +4 degree C
Long-term Storage: -20 degree C
Stable for at least 6 months after receipt when stored at -20 degree C.
Molecular Weight
~47kD (SDS-PAGE)
Chromosome Location
Chromosome: 1; NC_000001.10 (207076630..207095378, complement). Location: 1q32.1
OMIM
606015
3D Structure
ModBase 3D Structure for O60667
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Blocks the binding of FasL to Fas.

Other Notes

Small volumes of FAIM3 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FAIM3 purchase

MBS636741 is an active protein targeting FAIM3. Also known as Fas:Fc, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 6, TNFRSF6, Apo-1 Antigen, CD95). Host: Human, HEK 293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for FAIM3. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
fas apoptotic inhibitory molecule 3 isoform a
NCBI Official Synonym Full Names
Fas apoptotic inhibitory molecule 3
NCBI Official Symbol
FAIM3
NCBI Official Synonym Symbols
FCMR; TOSO
UniProt Protein Name
Fas apoptotic inhibitory molecule 3
UniProt Synonym Protein Names
Regulator of Fas-induced apoptosis Toso
UniProt Gene Name
FAIM3
UniProt Synonym Gene Names
TOSO
UniProt Entry Name
FAIM3_HUMAN
NCBI Protein Information
fas apoptotic inhibitory molecule 3; Fc mu receptor; IgM Fc receptor; immunoglobulin mu Fc receptor; regulator of Fas-induced apoptosis Toso

NCBI Summary for FAIM3

Fc receptors specifically bind to the Fc region of immunoglobulins (Igs) to mediate the unique functions of each Ig class. FAIM3 encodes an Fc receptor for IgM (see MIM 147020) (Kubagawa et al., 2009 [PubMed 19858324]; Shima et al., 2010 [PubMed 20042454]).[supplied by OMIM, Jul 2010]

UniProt Comments for FAIM3

FAIM3: May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: integral to membrane; extracellular region

Biological Process: immune system process; cellular defense response; negative regulation of apoptosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FAIM3 active protein

 Reference Product  PubMed Publications
 CD19 active protein  >1 publications with FAIM3 and CD19

Diseases associated with FAIM3 active protein

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